本論文主要在探討有機過渡金屬鉬、鉻羰基錯合物與帶官能基鋅銅試劑的加
成反應。再利用分子內環化反應，製造具高度立體選擇性並環雙環化合物的基本架構。

不同的官能化有機鋅銅試劑 RCu(CN)ZnI 與(η4-環己-1,3-二烯)(η5-還戊二烯基)二
羰鉬陽離子錯合物之親核加成反應，具有高度的立體及位置選擇性。 形成在碳-4位置
有官能鏈的中性(η3-環己烯基)(η5-環戊二烯基)二羰鉬錯合物。此錯合物經由去保
護反應，後用四氟硼酸亞硝醯，進行分子內環化反應，可得在環的碳-2位置含有異核
的氧、氮、硫原子並環雙環 [4.4.0] 癸烯化合物。

各種官能基化的有機鋅銅試劑RCu(CN)ZnI與(η7-環庚三烯基)三羰鉻陽離子錯合物，得
到在碳-7位置有官能鏈的(η6-環庚-1,3,5,-三烯)三羰鉻錯合物。其中官能基為酯類
的加成物在二異丙胺化鋰的作用下，進行分子內環化反應，產生並環雙環[5.3.0]癸烷
與[5.4.0]十一烷化合物。

六羰鉻與卞基醇在正丁醚和四氫夫喃(10:1)溶液中加熱迴流，生成(η6-卞基醇)三羰鉻
錯和物。(η6-卞基醇)三羰鉻錯合物經濃鹽酸處理，可得(η6-卞基氯)三羰鉻錯合物。
各種胺基酸衍生物與(η6-卞基氯)三羰鉻錯合物進行親核取代反應，得到含有胺基酸衍
生物的三羰鉻錯合物。在攝氏零度下，含胺基酸衍生物的三羰鉻錯合物與六甲基二矽胺
化鋰作用，進行分子內環化反應。當以碘氧化終止反應時，可得含氮雙環化合物-
1,2,3,4-四氫異奎寧；當以三氟醋酸終止反應，當加碘氧化後，可生成含氮並環雙環
[4.4.0]雙烯化合物。

A variety of highly functionalized zinc-copper reagents
RCu(CN)ZnI react regio- and stereospecifically with Dicarbonyl
(η5-cyclopentadienyl)(η4-cyclohexa-1,3-diene)molybdenum cation to generate
neutral Dicarbonyl (η5-cyclopentadienyl)(η3-allyl)molybdenum complexes with a
functionalized side-chain at the C-4 position of the ring. Deproction of
complexes followed by intramolecular cyclization using NOBF4 gave fused
bicyclo[4.4.0]decene derivatives containing an oxygen, nitrogen or sulfur atom
at the C-2 position of the rings.
The addition of a variety of highly functionalized znic-copper reagents
RCu(CN)ZnI to (tropylium)Cr(CO)3 cation gives
(η6-cyclohepta-1,3,5-triene)Cr(CO)3 complexes with a functionalized side-chain
at the C-7 position of the ring.Intramolecular cyclization of ester-substituted
adducts using lithium diisopropylamide generates fused bicyclo[5.3.0]decane
and -[5.4.0]undecane derivatives.
Benzyl alcohol chromium tricarbonyl complex was prepared in 75% yield by
treatmentreatment of chromium hexcarbonyl and benzyl alcohol in dibutyl
ether/tetrahydrofuran (10:1) under nitrogen.Reaction of benzyl alcohol chromium
tricarbonyl with concentrated hydrochloric acid gave benzyl chloride chromium
tricarbonyl(75%). the nucleophilic substitution reaction of a variety of amino
acid derivatives with benzyl chloride chromium tricarbonyl generated chromium
complexes with an amino acid derivative at the benzyl position.Intramolecular
cyclization of the complex using lithium hexamethyldisilazide followed by
oxidation with I2 led to fused bicyclic products.
A variety of highly functionalized zinc-copper reagents