本論文利用一價銠金屬與本實驗室開發之掌性雙環[2.2.1]雙烯配基L1e的催化系統，使各式烯醇醚基三氟硼酸鉀鹽試劑 53a‒f與芳香基亞胺10a‒o進行不對稱催化加成反應，在100 oC下以甲苯作為溶劑，添加100 wt%研磨過分子篩 (MS 4Å)，反應六小時，可合成出具有高鏡像選擇性的新型掌性烯丙基胺骨架之產物34，其產率為21%到83%，鏡像超越值為94%到>99.5% ee。
在合成應用上，利用合成出的新型掌性烯丙基胺化合物34ae，經由簡單的官能基轉變，就可以合成出市售藥物 (S)-Dapoxetine (60)。

This thesis describes the asymmetric synthesis of optically active amines bearing enol ethers.
In the presence of 5.0 mol% of the Rh(I) catalyst comprising chiral diene ligand L1e, the enantioselective addition of potassium enol ether trifluoroborates (53a‒f) to aldimines bearing N-Ts protecting groups afforded the desired allylic amines in 21– 83% yields with 94–>99.5% ee.
The method was applied to the total synthesis of (S)-Dapoxetine (60).

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