高密度脂蛋白(High Density Lipoprotein，HDL)被認為是粥狀動脈硬化的保護因子，有研究假說指出HDL不同的亞型(subclass)可能有不一致的保護效應，只含apolipoprotein A-I(apo A-I)不含apolipoprotein A-II (apo A-II)之亞型Lipoprotein A-I (Lp A-I)可能比同時含apo A-I及apo A-II之亞型Lipoprotein A-I:A-II (Lp A-I:A-II)能提供更多粥狀動脈硬化危險性的資訊。本研究沿用1990-1993年所收集409位台北地區健康中年人的資料，以SPSS for window version7.5的軟體進行統計分析，深入探討性別及停經對兩種高密度脂蛋白亞型Lp A-I和 Lp A-I:A-II的分佈是否有不同；並探討身體質量指數(Body Mass Index，BMI)、腰臀比(Waist Hip Ratio，WHR)、飲食與高密度脂蛋白亞型之相關性。結果顯示女性之HDL、Lp A-I和Lp A-I:A-II顯著大於男性(p<0.001)，而停經後婦女之HDL和Lp A-I:A-II顯著大於停經前婦女(p<0.05)。經由雙變項相關分析顯示Lp A-I和 Lp A-I:A-II與BMI(r=0.43 ; 0.24)和WHR(r=0.54 ; 0.27)具有顯著相關性，而與飲食則僅有微弱相關(r=0.01-0.26)。在控制年齡、BMI、抽煙和總熱量等因子的淨相關分析顯示，無論男女，WHR與Lp A-I有顯著的負淨相關，與Lp A-I:A-II無顯著的相關性；至於飲食與兩種HDL亞型之淨相關在男女則無共同趨勢。進一步再控制相關的飲食因素，無論男女皆顯示Lp A-I與WHR有顯著負相關，而Lp A-I:A-II 與WHR無顯著的相關性。經由各種多變項分析得知，WHR獨立於BMI之影響，為HDL亞型中Lp A-I而非Lp A-I:A-II的重要預測因子。

Plasma concentrations of high-density lipoprotein (HDL) are inversely correlated with the risk of coronary heart disease (CHD). HDLare heterogeneous in their apolipoprotein composition. Apolipoprotein (apo) A-I and apo A-II are the major protein found in HDL and form the two major HDL subclasses: those that contain only apo A-I (Lp A-I) and those that contain both apo A-I and apo A-II (Lp A-I: A-II). Substantialevidence indicates that these two HDL subclasses differ in their effect on atherosclerosis and may provide additional information in the assessmentof CHD risk. The purpose of the study was to examine whether thegender and menopausal-related differences in CHD risk may relate to differences in the two major HDL subclasses. We also examine the association of these two HDL subclasses with Body Mass Index(BMI)、Waist Hip Ratio(WHR) and diet. Our data indicate that women had significantly higher values of HDL、Lp A-I and Lp A-I:A-II than men.Post-menopausal status was associated with significantly higher values ofHDL and Lp A-I: A-II. We noted a strong correlation between these two HDL subclasses with WHR and BMI. Both in men and women, we did not observe consistent relations between these two HDL subclasses and diet. After adjustment for age、BMI、smoke、total energy and menopausal status(only for women), Lp A-I remained a significantly inverseassociation with WHR, but Lipoprotein A-I:A-II did not. Our data showed that the association of WHR with Lp A-I was independent from BMI and diet, Lp A-I but not Lp A-I: A-II was a better indicator of WHRthan HDL.