本研究是利用128通道全腦式腦磁圖儀來探討人類大腦聽覺皮質反應，在本文中我們著重討論在不同頻率的聲音刺激下，聽覺誘發的開端反應On-response(on-N1m)與終端反應Off-response(off-N1m)的空間演化特性。我們將受測者利用左耳及右耳分別聆聽250Hz, 1000Hz, 2000Hz的單調音時所產生的聽覺誘發磁場記錄下來，實驗總共有15位自願性的受測者參加這個試驗，在實驗中，我們成功的利用腦磁圖儀擷取到受測者左腦和右腦的聽覺誘發磁場，發現耳朵接收到不同頻率的聲音刺激後，左右腦都會產生On-N1m及Off-N1m訊號，接著利用單一等效電流偶極(equivalent current dipole, ECD)分別計算左腦和右腦的聽覺誘發磁場的發生機率和活化區域，根據On-N1m的數據統計可以發現左右耳接受聲音刺激時，對側腦的發生機率較高，且三頻率在對側腦的X方向上活化位置頻率越高，其大腦活化的分布較深層，經由統計方法T-test計算出250Hz和2000Hz的活化位置達顯著差異(p<0.05)。再根據Off-N1m的數據計算，大腦在接收到左右耳的聲音刺激結束後，皆以右半腦誘發的機率較高，在左耳接受聲音刺激下的右半腦活化位置看似有趨向性，但在統計上並無顯著差異，造成此結果的因素可能為有效人數不足或Off-N1m的訊號較弱不易觀測到或個體上差異，也可能本來就沒有趨向性。

1. M. Hamalainen et al., Magnetoencephalography – theory, instrumentation, and applications to noninvasive studies of the working human brain. Reviews of modern physics, 65 (1993) 413–497.
2. M.F. Bear et al., Neuroscience: exploring the brain. Third edition. Lippincott Williams & Wilkins.
3. M.A. Howard III et al., Auditory Cortex on the Human Posterior Superior Temporal Gyrus. THE JOURNAL OF COMPARATIVE NEUROLOGY, 416 (2000) 79–92.
4. T. Tuomisto et al., Studies of Auditory Evoked Magnetic and Electric Responses: Modality Specificity and Modelling. Il Nuovo Cimento D, 2 (1983) 471–483.
5. Luann E. Van Campen et al., Human offset auditory brainstem response: effects of stimulus acoustic ringing and rise-fall time. Hearing Research, 103 (1997) 35–46.
6. C. Pantev et al., Tonotopic organization of the human auditory cortex revealed by transient auditory evoked magnetic fields. Electroencephalography and clinical Neurophysiology, 69 (1988) 160–170.
7. C. Pantev et al., Tonotopic organization of the sources of human auditory steady-state responses. Hearing Research, 101 (1996) 62–74.
8. I.Ozaki et al., Dynamic movement of N100m dipoles in evoked magnetic field reflects sequential activation of isofrequency bands in human auditory cortex. Clinical Neurophysiology, 114 (2003) 1681–1688.
9. I. Ozaki et al., Rapid change of tonotopic maps in the human auditory cortex during pitch discrimination. Clinical Neurophysiology, 115 (2004) 1592–1604.
10. K. Noda et al., Auditory evoked off-response: its source distribution is different from that of on-response. NeuroReport, 9 (1998) 2621–2625.
11. K. Yamashiro et al., Somatosensory off-response in humans: An MEG study. NeuroImage, 44 (2009) 1363–1368.
12. K. Yamashiro et al., Automatic auditory off-response in humans: an MEG study. European Journal of Neuroscience, 30 (2009) 125–131.
13. L. Crevits et al., On and off contribution to the combined occipital on–off response to a pattern stimulus. Ophthalmologica, 184 (1982) 169–173.
14. Hyvärinen A. and Oja. E. (2000) Independent component analysis:algorithms and applications. Neural Networks 13(4-5):411-430
15. Kuen-Lin Chen, Hong-Chang Yang, Sung-Ying Tsai, Yu-Wei Liu, Shu-Hsien Liao, Herng-Er Horng, Yong-Ho Lee, and Hyukchan Kwon. The stability of source localization in a whole-head Magnetoencephalography system demonstrated by auditory evoked field measurements; J. Appl. Phys. 110, 074702 (2011).
16. 劉瑜偉(2011)。用128通道腦磁圖儀系統研究人類大腦聽覺誘發磁場。未出版之碩士論文，國立台灣師範大學光電科技研究所，台北。
17. M.A. Howard III et al., A chronic microelectrode investigation of the tonotopic organization of human auditory cortex. Brain Research, 724 (1996) 260-264.
18. C. Pantev et al., Specific tonotopic organizations of different areas of the human auditory cortex revealed by simultaneous magnetic and electric recordings. Electroencephalography and clinical Neurophysiology 94 (1995) 26-40