不同運動強度對高密度脂蛋白膽固醇的影響
研 究 生：呂香珠
民國八十八年六月 指導教授：林正常
吳文惠
摘 要
運動後，導致高密度脂蛋白膽固醇(HDL-C)增加的機制，可能在於運動消耗極低密度脂蛋白的三酸甘油酯(VLDL-TG)，因而降低膽固醇酯轉送蛋白(CETP)的作用，進而抑制HDL-C與VLDL-TG的交換。
基於此一機制，以及中強度代謝較多VLDL-TG的研究事實，本論文的研究目的即在探討：中、低運動強度，當運動量足夠大時，是否皆能引起HDL-C增加？其次，在等運動量下，中強度運動對增加HDL-C的效果是否優於低強度運動？
本研究以10名健康、無抽煙習慣、年齡18～28歲之大學男生作為受試者。以單因子重複量數設計，依實驗平衡法，每位受試者分別接受55%VO2max中強度跑步，和35%VO2max低強度走步的運動處理，每次運動量為900卡。兩次運動間隔一星期。運動於晚餐後三小時開始進行，以EDTA的真空採血管採取血液樣本共四次，分別為運動當日早晨（空腹，當作基準樣本）、運動前10分鐘、運動停止後10分鐘、及運動停止後第11小時(第二天上午，空腹)。血漿分析項目有：HDL-C、總膽固醇、VLDL-TG、總TG四項，每一項資料皆依血容積修正過。
研究結果發現：中強度運動後10分鐘及11小時，HDL-C皆顯著多於基準值，總膽固醇量則無顯著減少；低強度運動之後，HDL-C和總膽固醇與基準值相比較，則皆無顯著差異。中強度運動後11小時，HDL-C的增加量為3.11±1.88mg/dl，增加率為8.09 ±5.24％，兩者皆顯著多於低強度運動（-0.34±2.85mg/dl、-0.74 ±6.86％）。而同時間，中強度運動後VLDL-TG顯著減少，低強度則否。總TG雖無顯著減少，但仍以中強度運動後減少較多。
本研究的結論是：在單次等運動量下，中強度對增加HDL-C的效果優於低強度。中強度運動後HDL-C顯著增加，與VLDL-TG被大量消耗掉有關。欲顯著增加HDL-C，如以中強度單次運動，則運動量達900卡即可；若以低強度運動，則900卡的運動量仍嫌不足。
關鍵詞：高密度脂蛋白膽固醇、血漿總膽固醇、血漿三酸甘油酯、
極低密度脂蛋白三酸甘油酯、運動強度。

Effects of Acute Low and Moderate Exercise Intensities on
High-Density Lipoprotein Cholesterol
June, 1999 Student: Hsiang-Chu Leu
Advisors: Jung-Charng Lin
Wen-Hui Wu
ABSTRACT
The purpose of this study was to investigate the effects of moderate intensity exercise (MIE) and low intensity exercise (LIE) with equal energy expenditure (900 Kcal) on high-density lipoprotein cholesterol (HDL-C). Ten healthy, no smoking habit male college students (18-28 yrs.) counterbalancedly performed treadmill running with MIE at 55%VO2max and walking with LIE at 35%VO2max on 7 days separately. Exercise was performed at 3 hours after dinner. For each trial, blood samples were collected at the morning pre-exercise in a fasted state for baseline, 10 min pre-exercise, 10 min post-exercise (IPE) and 11h post-exercise (11h PE, the next morning in a fasted state). Plasma HDL-C, total-cholesterol(TC), triacylglycerol(TG), and very low-density lipoprotein triacylglycerol (VLDL-TG) were measured. All samples were corrected for plasma volume changes. A significant increase (p<0.05) in HDL-C was observed at IPE and 11h PE after MIE trial, and there was no decrease in TC after both two trials. Both of the increasing magnitude and percentage of HDL-C after MIE were significantly higher than LIE (3.11±1.88mg/dl vs. -0.34 ±.85mg/dl; 8.09±5.24％ vs. -0.74±6.86％). VLDL-TG was significantly decrease after MIE trial but not LIE trial. These results suggest that MIE is better than LIE to elevate HDL-C with equal energy expenditure, and the elevating effect of MIE on HDL-C is related to the consumption of VLDL-TG. It also suggests that 900 Kcal energy expenditure is enough to promote favorable changes in HDL-C by MIE but not LIE.
Key words: exercise intensity, high-density lipoprotein
cholesterol(HDL-C),
total cholesterol(TC), triacylglycerol(TG),
very low density lipoprotein-triacylglycerol(VLDL-
TG)

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