近年來運動休閒普受世人重視，環島運動在台灣興起一片熱潮。中等強度運動能促進身體健康已眾所周知，長時間運動則會產生運動後免疫抑制現象，淋巴細胞在免疫系統中扮演重要角色，從免疫學角度來看連續數天長時間的中等強度運動，對人體淋巴細胞亞群的變化趨勢仍不明瞭，本研究將以連續數天長時間直排輪環島運動作為觀察焦點，探討淋巴細胞比例及相關性之影響與關連。
本研究以9名健康男性（平均年齡：20.78 ± 2.22歲，直排輪溜齡：9.44 ± 2.13年，最大攝氧量：54.49 ± 5.87 ml．min-1．kg-1），進行連續七天的直排輪環島運動（全程953公里），於環島第一天出發前、第七天結束後、結束後36小時、結束後10天，4個時間點進行採血，比較淋巴球細胞亞群CD3+CD4+、CD3+CD8+、CD3-CD19+、CD3-CD16+CD56+百分比、CD4+/ CD8+比例變化情形及相關性。所得數據，以重複量數單因子變異數及皮爾遜積差相關進行分析。結果發現，CD4+/ CD8+值在環島後顯著下降（p< .05），CD3+CD4+ 、CD3-CD19+於第七天全程環島結束後，其比例顯著低於環島前（p< .05），且在環島運動後36小時恢復期仍呈現持續下降（p< .05）。CD3-CD16+CD56+在環島後顯著上升（p< .05），CD3+CD8+於環島過程中並無顯著變化；淋巴細胞亞群之間部分在環島運動前後呈現正相關性。結論：直排輪環島運動後，造成淋巴細胞亞群CD3+CD4+、CD3-CD19+比例下降之趨勢，表示於連續天數長時間耐力運動後會產生免疫抑制現象，此時急病感染機率可能增加，應特別注意身體保養。

Sport Leisure is getting popular and prevent during the past few years. Especially In-line skating around the island that becomes the hit. As we know, moderate exercise can enhance the health. Long term exercise will generate immunosuppression phenomenon from which lymphocyte plays an important role. In the aspect of immunology, it is still unclear to know the variation of lymphocyte subsets in the body after continuous moderate exercise for several days. This research will show the result of lymphocyte percentage and the related impact after continuous long term exercise of in-line skating around the island. The research is proceeded with nine healthy males (average age: 20.78 ± 2.22 years, experience of in-line skating: 9.44 ± 2.13 years, maximum oxygen intake: 54.49 ± 5.87 ml．min-1．kg-1), for seven days in a raw of in-line skating around the island (total of 953 kilometers). The blood sample was taken under four conditions: 1.before departure of the journey, 2. the closing day of the journey, 3. during 36 hours after journey, 4. during 10 days after journey. The blood sample was used to compare percentage of lymphocyte subsets CD3+CD4+, CD3+CD8+, CD3-CD19+, CD3-CD16+CD56+, variation and related impact of CD4+/ CD8+. The data are analyzed by repeated one-way ANOVA and Pearson product moment correlation. The result is as following: CD4+/ CD8+ decrease obviously after In-line skating around island and percentage of CD3+CD4+ , CD3-CD19+ is much lower than departure the journey which keeps decreasing during 36 hours after the journey (p< .05). CD3-CD16+CD56+ increase obviously (p< .05) and there is no apparent change for CD3+CD8+ during the whole journey. Lymphocyte subsets show the opposite relation before and after the journey. Conclusion: After In-line skating around island, it causes the decrease of percentage of CD3+CD4+ and CD3-CD19+, generate the immunosuppression and open window of immune. It is important to take care of body after long term exercise for several days due to the weakening of immunity that may possibly cause the infection.

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