目前最常使用的自動DNA定序法，屬於較費時間與資源的方法，加上最近興起的奈米洞蝕刻技術，能使奈米洞的尺寸做到與單股DNA直徑差不多，透過在基膜上鑿出奈米洞，在膜的兩邊加電壓，讓帶負電的單股DNA穿透過去，再量測電流值，由於每個核酸分子的大小不同，堵塞效應所造成的電流訊號也會不同，藉此分辨出單股DNA分子鏈上的序列。本模擬提出的方法，除了實驗上加的垂直基膜的電場外，並在基膜上方，加入一個以奈米洞為旋轉中心的旋轉電場，幫助核酸分子在洞口停留時間久一 點，讓電流序號更明顯，在搭配本論文提出的比對方法，使得即使電流訊號有遺失，也能利用不同組數據補其不足，進而定出完整的DNA序列。

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