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研究生: 艾競一
Ai, Jing-Yi
論文名稱: 急性MICT和LV-HIIT對中老年人執行功能影響 :事件相關電位研究
Effect of Acute MICT and LV-HIIT on Inhibition in Late-middle-aged Adults: An ERPs Study
指導教授: 張育愷
Chang, Yu-Kai
口試委員: 洪聰敏
Hong, Tsung-Min
林儷蓉
Lin, Li-Jung
阮啟弘
Juan, Chi-Hung
王駿濠
Wang, Chun-Hao
張育愷
Chang, Yu-Kai
口試日期: 2023/07/31
學位類別: 博士
Doctor
系所名稱: 體育與運動科學系
Department of Physical Education and Sport Sciences
論文出版年: 2023
畢業學年度: 111
語文別: 英文
論文頁數: 75
中文關鍵詞: LV-HIITMICT抑制控制乳酸中老年人
英文關鍵詞: LV-HIIT, MICT, inhibition, lactate, late-middle-aged adults
研究方法: 實驗設計法
DOI URL: http://doi.org/10.6345/NTNU202301009
論文種類: 學術論文
相關次數: 點閱:105下載:13
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  • 近年來,全球高齡化浪潮來襲,老化已成為現今社會需要重視的課題,伴隨著認知退化與罹患失智症的案例與日俱增,使得如何提升中老年人認知功能的議題越來越受到重視。高強度間歇訓練 (HIIT) 可以改善認知功能和表現。大多數HIIT研究採用 "全力以赴 "的可變負荷運動干預,然而這可能不安全,也不能被特定的人 (中高齡或者病患等) 所接受。低量HIIT是為了確定性能、代謝和分子適應更實用的模型,儘管總運動量低,但其效益可以類似于傳統耐力訓練并且產生積極的情緒價值。此外,急性運動誘發乳酸濃度之提升可能與認知表現之增進產生關聯。因此,本研究之目的為探討急性中等强度連續運動 (MICT)和低量HIIT (LV-HIIT)對中老年人抑制控制之影響。本文採用對抗平衡組内設計,參與者按順序隨機分派至完成30分鐘的急性MICT、19分鐘LV-HIIT或30分鐘非運動干預 (觀看影片) 。當參與者在基線和干預模式後執行Stroop任務時,同時測量神經心理學[即準確率 (ACC) 和反應時間 (RT) ]、神經生理學[即事件相關電位 (ERP) P3和N450振幅]以及血清中乳酸濃度指標。主要結果表明,MICT和LV-HIIT對抑制控制的行爲表現有相似的效益,其中LV-HIIT對神經電激活有特定的内在歷程,次要結果表明,LV-HIIT產生較多的乳酸並令人充滿愉悅感。總而言之,LV-HIIT可能是一種更省時高效率來改善認知健康的方法。

    Aging has emerged as a significant concern in our society because of the recent worldwide aging trend. Additionally, there is a growing emphasis on improving the cognitive function of the elderly due to the rise in the incidence of dementia and cognitive decline in middle-aged people. Previous research has demonstrated the value of high-intensity interval training (HIIT) in enhancing cognitive ability. However, the 'all-out' variable-load exercise regimens that are frequently used in most HIIT studies might not be suitable for everyone or be well tolerated by them. To address this issue, low-volume HIIT (LV-HIIT) was developed as a more practical model that can produce metabolic and molecular adaptations similar to endurance training despite a lower total exercise volume. Our main goal was to determine how a single session of LV-HIIT and MICT affected middle-aged people’s inhibitory control. The impact of an acute exercise-induced elevation in lactate on the cognitive performance of senior citizens was another goal of our research. Participants randomly conducted 30 min of MICT, 19 min of LV-HIIT, or a non-exercise intervention (CON) session in a counterbalanced order using a counterbalanced crossover design. We simultaneously measured neuropsychological indices (accuracy rate and reaction time) and neurophysiological indices (event-related potential P3 and N450 amplitude) using a Stroop task at baseline and after each intervention mode. To summarize, the findings of the current study indicate that MICT and LV-HIIT have the same inhibition performance and differential underlying neuroelectric activation. The study implies that LV-HIIT may be a more time-effective strategy for enhancing cognitive health.

    Chapter 1 Introduction 1 1.1 Background 1 1.2 Study purpose 6 1.3 Study hypotheses 6 Chapter 2 Review of the literature 7 2.1 Executive function in late-middle-aged adults 7 2.2 Effect of acute exercise on EF in late-middle-aged adults 7 2.2.1 Effect of acute exercise-induced lactate on cognition 8 2.2.2 Effect of acute LV-HIIT and MICT on EF in middle-aged adults 9 2.2.3 Effect of acute LV-HIIT and MICT on enjoyment in middle-aged adults 11 2.3 Effect of acute exercise on P3 and N450 12 2.3.1 Effect of acute LV-HIIT and MICT on P3 and N450 12 2.4 Effect of acute exercise on P3 and N450 14 2.5 Summary 15 Chapter 3 Methodology 17 3.1 Participant 17 3.2 Study design and experimental trials 17 3.2.1 Study design 17 3.2.2 Experimental trials 17 3.2.3 Standardized breakfast 18 3.3 Measures 19 3.3.1 Stroop task 19 3.3.2 Event-related potential assessment 19 3.3.3 Measurement of lactate concentration and Heart Rate 20 3.3.4 PACES 20 3.3.5 MMSE 20 3.3.6 IPAQ 20 3.4 Submaximal graded exercise test 21 3.4.1 Herat rate (HR) 21 3.4.2 Rating of perceived exertion (RPE) 21 3.4.3 Submaximal graded exercise test 21 3.5 Intervention 22 3.5.1 LV-HIIT 22 3.5.2 MICT 22 3.5.3 Control condition (CON) 22 3.6 Data analysis 23 Chapter 4 Results 25 4.1 Descriptive Data 25 4.2 Behavioral 26 4.2.1 Behavioral results 26 4.2.2 PA is correlated with performance on the Stroop task 26 4.2.3 Heart Rate Responses 27 4.3 Neuroelectric measures 30 4.3.1 P3 amplitude 30 4.3.2 N450 amplitude 32 4.4 Molecular biomarkers 35 4.4.1 Lactate 35 4.4.2 Correlations between the neurocognitive and molecular indices 36 4.4.3 Subjective Responses 36 Chapter 5 Discussion 38 5.1 Behavioral indices 38 5.2 Neuroelectric indices 40 5.3 Brain mechanisms underlying modulations 44 5.4 Subjective Responses 46 5.5 Strengths and limitations 48 5.6 Significance for the field 49 Chapter 6 Conclusion 51 References 52

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