簡易檢索 / 詳目顯示

研究生: 劉宜佳
論文名稱: 實驗室環境之低磁場核磁共振系統架設及應用
指導教授: 楊鴻昌
Yang, Hong-Chang
洪姮娥
Horng, Herng-Er
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2008
畢業學年度: 96
語文別: 中文
論文頁數: 58
中文關鍵詞: 低磁場核磁共振地球磁場之核磁共振預極化場時域頻率調整平均j-coupling
論文種類: 學術論文
相關次數: 點閱:113下載:0
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報
  • 我們架設可於實驗室環境下進行低磁場核磁共振量測之系統,此系統之特點為不需將系統放置於屏蔽環境即可量測。然而在磁共振實驗中樣品之磁化量隨著預極化場之磁場大小增加而增加,因此在實驗中以0.75 Tesla之釹鐵硼磁鐵做為預極化場,使樣品之磁化量增加,並利用前級放大器將法拉第線圈所接收到之磁共振訊號放大以利於傳輸。又因環境之磁場值會隨時間變化,使得磁共振之共振頻率也隨之改變,為使訊雜比能經由平均而增加,我們採用時域頻率調整平均(Time-domain Frequency Adjusted Averaging, TFAA)提升磁共振頻譜之雜訊比。此外,在低磁場核磁共振中無法顯現化學位移之特性,使得j-coupling訊號能從中辨識,有助於分析分子之幾何結構。

    第一章 緒論.....................................1 1.1 低磁場核磁共振簡介...........................1 1.2 核磁共振原理................................3 第二章 實驗架構.................................10 2.1 低磁場核磁共振系統設計.......................10 2.2 訊號量測...................................19 第三章 實驗結果與數據討論.........................21 3.1 使用法拉第線圈量測之結果......................21 第四章 結論及未來展望............................52 參考文獻.......................................54 致謝...........................................58

    1. P.T. Callaghan, M. Legros, “Nuclear spins in the Earth’s magnetic field, “Am. J. Phys. 50 ,709 (1982)
    2. Bene GJ, 4 Int. S. Magn. Res. Reh. (1971).
    3. G.J. Bene, “Nuclear magnetism of liquid-systems in the Earth’s field range”, Phys. Rep. 58,213 (1980).
    4. P.T. Callaghan, C.D. Eccles, J.D. Seymour, “An Earth’s field nuclear magnetic resonance apparatus suitable for pulsed gradient spin echo measurements of self-diffusion under Antarctic conditions”, Rev. Sci. Instrum. 68, 4263 (1997)
    5. P.T. Callaghan, C.D. Eccles, T.G. Haskell, P.J. Langhorne, J.D. Seymour, “Earth’s field NMR in Antarctica: a pulsed gradient spin echo NMR study of restricted diffusion in sea ice”, J. Magn. Reson.133, 148 (1998).
    6. P.T. Callaghan, R. Dykstra, C.D. Eccles, T.G. Haskell, J.D. Seymour, “A nuclear magnetic resonance study of Antarctic sea ice brine diffusivity”, Cold Reg. Sci. Technol. 29 ,153 (1999)
    7. O.R. Mercier, M.W. Hunter, P.T. Callaghan, “Brine diffusion in firstyear sea ice measured by Earth’s field PGSE-NMR”, Cold Reg. Sci.Technol. 42, 96 (2005).
    8. J.S. Brown Robert, “Earth’s field nuclear magnetic logging”, Concept.Magnetic Res. 13, 344 (2001).
    9. S. Appelt, F. W. Hasing, H. Kuhn, U. Sieling, and B. Blumich,” Analysis of molecular structures by homo- and hetero-nuclearJ-coupled NMR in ultra-low field”.Chem. Phys. Lett. 440, 308 (2007)
    10. S. Appelt, A. Ben-Amar Baranga, C.J. Erickson, M.V. Romalis, A.R.Young, W. Happer, ”Theory of spin-exchange optical pumping of 3He and 129Xe “, Phys. Rev. A 58, 1412 (1998).
    11. M. Goldman, H. Jo’hannesson, O. Axelsson, M. Karlsson, “Hyperpolarization of 13C through order transfer from parahydrogen: A new contrast agent for MRI “, Magn.Reson. Imaging 23,153 (2005) .
    12. G. Navon, Y.-Q. Song, T. Ro˜o˜m, S. Appelt, R.E. Taylor, A. Pines,” Enhancement of Solution NMR and MRI with Laser-Polarized Xenon”, Science 271, 1848 (1996).
    13. S. Appelt, F.W. Ha‥sing, S. Baer-Lang, N.J. Shah, B. Blümich, “Enhancement of Solution NMR and MRI with Laser-Polarized Xenon”, Chem.Phys. Lett. 348, 263 (2001)
    14. Shu-Hsien Liao and Herng-Er Horng, Hong-Chang Yang, and Shieh-Yueh Yang, “Longitudinal relaxation time detection using a high-Tc superconductive quantum interference device magnetmeter”, J. Appl. Phys. 102, 033914 (2007).
    15. M.A. Espy, A.N. Matlachov, P.L. Volegov, J.C. Mosher, and R.H. Kraus Jr., ” SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields”, IEEE Trans. Appl. Supercon. 15, 635 (2005).
    16. A.H. Trabesinger, R. McDermott, S.K. Lee, M. Mu1ck, J. Clarke, and A. Pines , “ SQUID-Detected Liquid State NMR in Microtesla Fields“, J. Phys. Chem. A, 108, 957-963 (2004).
    17. R. McDermott, S.K. Lee, B. ten Haken, A.H. Trabesinger, A. Pines, and J. Clarke, “Microtesla MRI with a superconducting quantum interference Device”, Proc. Natl. Acad. Sci. USA , 101, 7857 (2004).

    18. M. Mössle, S. Busch, M. Hatridge, W. Myers, A. Pines, and J. Clarke, “SQUID-detected microtesla MRI: a new modality for tumor detection”, paper presented at 2006 Applied Superconductivity conference, Aug. 27-Sept.1, 2006, Seattle, Washington, USA.
    19. A.E. Derome, "NMR Techniques for Chemistry Research", Pergamon Press, NY 1987.
    20. Atta-ur-Rahman, "Nuclear Magnetic Resonance, Basic Principles", Springer-Verlag, NY 1986.
    21. Brend Seeber, Handbook of Applied Superconductivity
    22. W.G. Proctor, F.C. Yu, “On the Nuclear Magnetic Moments of Several Stable Isotopes “, Phys. Rev. 81, 20 (1951).
    23. W.G. Proctor, F.C. Yu, “The Dependence of a Nuclear Magnetic Resonance Frequency upon Chemical Compound “, Phys. Rev. 77, 717 (1950)
    24. R. Freeman, A Handbook of Nuclear Magnetic Resonance, Longman Scientific & Technical, Essex, England, (1988).
    25. Medek, L. Frydman, “Multiple - Quantum Magic - Angle Spinning NMR: A New Technique for Probing Quadrupolar Nuclei in Solids”, J. Braz. Chem. Soc. 10, 263(1999)
    26. M A Bernstein, K F King and X J Zhou. Handbook of MRI Pulse Sequences. Elsevier Academic Press, 960 (2004)
    27. Zhi-Pei Liang and Paul C. Lauterbur, ”Principles of Mageetic Resonance Imaging: A Signal Processing Perspective”.
    28. Sasada and Y. Nakashima, “Planar coil system consisting of three coil pairs for producing a uniform magnetic field”, J. Appl. Phys. 99, 08D904(2006)
    29. S. Appelt, H. Kühn, F. W. Häsing, and B. Blümich, “Chemical analysis by ultrahigh-resolution nuclear magnetic resonance in the Earth’s magnetic field”, Nat. Phys. 2, 105 (2006)
    30. Longqing Qiu, Yi Zhang, Hans-Joachim Krause, and Alex I. Braginski, “Nuclear magnetic resonance in the earth’s magnetic field using a nitrogen-cooled superconducting quantum interference device”, Appl. Phys. Lett. 91,072505 (2007)
    31. Robert McDermott, Andreas H. Trabesinger, John Clarke,” Liquid-State NMR and Scalar Couplings in Microtesla Magnetic Fields”, Science, 295,2247 (2002)
    32. Meghan E. Halse, Andrew Coy, Robin Dykstra, Craig Eccles, Mark Hunter, Rob Ward, Paul T. Callaghan, “A practical and flexible implementation of 3D MRI in the Earth’s magnetic field”, J. Magn. Reson. 182,75 (2006)

    無法下載圖示 本全文未授權公開
    QR CODE