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研究生: 陳勇志
Yung-Chih Chen
論文名稱: 中年男性代謝症候群者心肺功能及心磁圖特性之研究
The Comparison of the of Endurance Capability and Magnetocardiography Variables Between the Healthy and Metabolic syndrome Middle-aged Male
指導教授: 方進隆
Fang, Chin-Lung
學位類別: 碩士
Master
系所名稱: 體育學系
Department of Physical Education
論文出版年: 2008
畢業學年度: 96
語文別: 中文
論文頁數: 68
中文關鍵詞: 代謝症候群心肺功能心磁圖中年男性心肌缺氧
英文關鍵詞: Metabolic syndrome, Endurance capability, Magnetocardiography (MCG), Male of middle age, Ischemia
論文種類: 學術論文
相關次數: 點閱:213下載:33
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  • 目的:探討中年男性代謝症候群者心肺功能(六分鐘走路測驗、心跳變異率)、身體組成及心磁圖參數特性。方法:以國民健康局 2006年訂定代謝症候群定義為標準,招募45~55歲代謝症候群(MS組,30名)及非代謝症候群男性(CT組,35名),共65名受試者參與實驗。心磁圖參數利用 ROC 曲線判斷其結果;其他資料以 SPSS for Windows 13.0 進行獨立樣本 T-test 考驗兩組各項目有無顯著差異,並利用皮爾遜積差相關檢驗體脂肪率、六分鐘走路測驗和心磁圖參數相關性,顯著水準 (P<.05)。結果:MS組體脂肪率顯著高於 CT組 (p<.05),肌肉重兩組無顯著差異;MS 組六分鐘走路測驗顯著低於 CT 組 (p<.05);兩組於安靜心跳率 (Mean HR)、Mean RR、HF(%)、LF/HF 皆未達顯著差異;心磁圖參數,MS 組在 SIQTc、QTc dispersion 明顯較 CT組高,Magnetic Dipole Angle (α角) 則無差異;由皮爾森積差相關檢驗後發現,QTc dispersion 和體脂肪率呈顯著正相關 (p<.05),和六分鐘走路呈顯著負相關 (p<.05)。結論:本研究發現代謝症候群者體脂肪率較高,且心肺適能上表現較差,由心磁圖參數SIQTc、QTc dispersion 結果可發現,代謝症候群者有較高的機率出現心肌缺氧症狀,且三者之間具有明顯的相關性,顯示代謝症候群者心肺功能下降時可能伴隨心肌缺氧等生理性病變產生。

    Purpose:The purpose of this study was to compare the endurance capability、body composition、heart rate variability and magnetocardiography (MCG) between healthy and metabolic syndrome Middle-aged males. Method:65 middle age males between 45~55 were recruited in this research, including those with metabolic syndrome (group MS, N=30) and non-metabolic syndrome (group CT, N=35). Metabolic syndrome was defined by Bureau of Health Promotion, Department of Health, in 2006. All the test variables were measured in both groups. The parameter of MCG was analyzed by ROC Curve, and the remaining data were analyzed using independent sample T-test with the statistical software SPSS for Windows 13.0. The Pearson’s product-moment correlation was used to assess the correlation between percentage of body fat and endurance capacity with MCG. Results:The percentage of body fat of group MS were significant higher than group CT (p<.05). For muscle mass, no difference between groups were found. The distance of walking for six minutes of group MS was significant lower than group CT (p<.05). The heart rate of resting、Mean RR、HF (%)、LF/HF (%) were not found to be different between groups. The parameter of MCG, SIQTc、QTc dispersion of group MS were higher than group CT. The α-Angle was not found to be different between these two groups. Percentage of body fat positively correlated with QTc dispersion (p<.05). The distance of walking for six minutes negatively correlated with QTc dispersion (p<.05). Conclusion:Participants with metabolic syndrome have higher percentage of body fat and worse endurance capability. The parameter of MCG (SIQTc、QTc dispersion) show that the people with metabolic syndrome have higher probability with ischemia. The percentage of body fat, endurance capability and parameter of MCG have significant relevance. It is demonstrated that people with metabolic syndrome have drop in endurance capability possibly associated with pathological change linked with ischemia.

    目次 第壹章 緒論 一、問題背景………………………………………………………… 1 二、研究目的………………………………………………………… 4 三、需無假設………………………………………………………… 4 四、名詞操作性定義………………………………………………… 4 五、研究範圍與限制………………………………………………… 7 六、研究的重要性…………………………………………………… 7 第貳章 文獻探討 一、代謝症候群及其危險因子與發病機制………………………… 8 二、代謝症候群對心肺功能之影響…………………………………12 三、代謝症候群和心血管疾病相關性之探討………………………15 四、心磁圖原理及臨床上的應用價值………………………………19 五、本章總結…………………………………………………………23 第參章 研究方法與步驟 一、受試對象…………………………………………………………24 二、實驗時間與地點…………………………………………………25 三、研究工具與檢測項目……………………………………………25 四、實驗方法與步驟…………………………………………………32 五、測驗變項…………………………………………………………33 六、資料處理與統計分析……………………………………………34 第肆章 結果 一、判定代謝症候群指標……………………………………………35 二、基本資料及身體組成……………………………………………36 三、六分鐘走路測驗…………………………………………………37 四、心跳變異率………………………………………………………38 五、心磁圖參數………………………………………………………38 六、體脂肪率及六分鐘走路測驗和心磁圖參數之相關性…………41 第伍章 討論與結論 一、代謝症候群與身體組成…………………………………………43 二、代謝症候群與六分鐘走路測驗…………………………………43 三、代謝症候群與心跳變異率………………………………………46 四、代謝症候群與心磁圖參數………………………………………49 五、體脂肪及六分鐘走路和心磁圖參數相關性之探討……………53 六、結論………………………………………………………………53 七、建議………………………………………………………………54 引用文獻 中文部份………………………………………………………………55 英文部份………………………………………………………………55 附錄 附錄一 受試者須知………………………………………………… 64 附錄二 受試者同意書……………………………………………… 65 附錄三 健康況狀調查表…………………………………………… 66 附錄四 運動習慣問卷表…………………………………………… 67 附錄五 受試者基本資料…………………………………………… 68 表 次 表 4-1、判定代謝症候群指標……………………………………………35 表 4-2、基本資料及身體組成……………………………………………36 表 4-3、六分鐘走路測驗…………………………………………………37 表 4-4、心跳變異率(fast Fourier transform,FFT analysis)38 表 4-5、SIQ ………………………………………………………………………………………………………………39 表 4-6、QTc dispersion……………………………………………………………………………………40 表 4-7、Magnetic Dipole Angle(α角)………………………………41 表 4-8、體脂肪率與心磁參數之相關 ……………………………………41 表 4-9、六分鐘走路測驗與心磁參數之相關 ……………………………42 圖 次 圖 1-1、ROC Curve ………………………………………………………………………………………………6 圖 2-1、代謝症候群的病因、進展與後果………………………………11 圖 3-1、腰圍量測…………………………………………………………26 圖 3-2、身體組成量測……………………………………………………27 圖 3-3、六分鐘走路測驗…………………………………………………28 圖 3-4、心磁圖量測示意圖………………………………………………30 圖 3-5、心磁圖量測定位點示意圖………………………………………30 圖 3-6、心磁圖與 Dipole方向…………………………………………31 圖 3-7、正α 角……………………………………………………………31

    一、中文部份
    方進隆(1993)。健康體能的理論與實際。台北市:漢文書店。
    王顯智、黃美雪(2007)。心率變異度的發展與臨床應用。中華體育季刊,21(3),1-9。
    吳宗曄(2005)。SQUID梯度計應用於兔子心臟生理學之研究。國立台灣師範大學光電科技研究所碩士論文,未出版,台北市。
    吳秉樺(2005)。低溫SQUID應用於人體心臟磁場測量之研究,國立台灣師範大學光電科技研究所碩士論文,未出版,台北市。
    洪斌峰(2006)。超導量子干涉心磁儀應用於高血脂兔子心臟心磁圖與生理學的研究。國立台灣師範大學光電科技研究所碩士論文,未出版,台北市。
    馮世祥、羅慶徽、陳宏一、徐尚為、朱基銘與林金定(2007)。某醫學中心員工代謝症候群盛行率與影響因子初探。中華職業醫學雜誌,14(3),141-147。
    黃麗卿、黃國晉 (2007)。代謝症候群的定義與流行病學。台灣醫學, 11(4),363-369。
    蔡明成(2007)。心磁圖用於心肌缺氧特性之研究。國立台灣師範大學光電科技研究所碩士論文,未出版,台北市。
    蔡崇煌、黃素雲與林高德 (2006)。代謝症候群與其相關因子之研究—健檢資料分析。台灣家醫誌,16(2),112-122。
    楊宜青、張智仁 (2007)。代謝症候群、肥胖和糖尿病。台灣醫學,11(4),370-380。

    二、英文部分
    Alpert, B. S., & Collins, R. T. (2007). Assessment of vascular function: pulse wave velocity. The Journal of Pediatrics, 150(3), 219-220.
    Arsenault, B. J., Lachance, D., Lemieux, I., Almeras, N., Tremblay, A., Bouchard, C., et al. (2007). Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome. Archives of Internal Medicine, 167(14), 1518-1525.
    Anzai, H., & Hayashida, N. (2007). [Metabolic syndrome]. Kyobu Geka, 60(11), 1011-1017.
    Ball, G. D., Shaibi, G. Q., Cruz, M. L., Watkins, M. P., Weigensberg, M. J., & Goran, M. I. (2004). Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obesity Research, 12(1), 77-85.
    Baron, A. D. (2002). Insulin resistance and vascular function. Journal of Diabetes and Its Complications, 16(1), 92-102.
    Baule, G. & Mcfee, R. (1963). Detection of the magnetic field of the heart. American Heart Journal, 66, 95-96.
    Benson, A. C., Torode, M. E., & Singh, M. A. (2006). Muscular strength and cardiorespiratory fitness is associated with higher insulin sensitivity in children and adolescents. International Journal of Pediatric Obesity, 1(4), 222-231.
    Berkoff, D. J., Cairns, C. B., Sanchez, L. D., & Moorman, C. T., 3rd. (2007). Heart rate variability in elite American track-and-field athletes. Journal of Strength and Conditioning Research, 21(1), 227-231.
    Bertoli, A., Di Daniele, N., Ceccobelli, M., Ficara, A., Girasoli, C., & De Lorenzo, A. (2003). Lipid profile, BMI, body fat distribution, and aerobic fitness in men with metabolic syndrome. Acta Diabetologica, 40 Suppl 1, S130-133.
    Bertrais, S., Beyeme-Ondoua, J. P., Czernichow, S., Galan, P., Hercberg, S., & Oppert, J. M. (2005). Sedentary behaviors, physical activity, and metabolic syndrome in middle-aged French subjects. Obesity Research, 13(5), 936-944.
    Bots, M. L., Hoes, A. W., Koudstaal, P. J., Hofman, A., & Grobbee, D. E. (1997). Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation, 96(5), 1432-1437.
    Brage, S., Wedderkopp, N., Ekelund, U., Franks, P. W., Wareham, N. J., Andersen, L. B., et al. (2004). Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children: the European Youth Heart Study (EYHS). Diabetes Care, 27(9), 2141-2148.
    Brien, S. E., Janssen, I., & Katzmarzyk, P. T. (2007). Cardiorespiratory fitness and metabolic syndrome: US National Health and Nutrition Examination Survey 1999-2002. Applied Physiology, Nutrition, and Metabolism, 32(1), 143-147.
    Carney, R. M., Freedland, K. E., Miller, G. E., & Jaffe, A. S. (2002). Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. Journal of Psychosomatic Research, 53(4), 897-902.
    Chinali, M., Devereux, R. B., Howard, B. V., Roman, M. J., Bella, J. N., Liu, J. E., et al. (2004). Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study). The American Journal of Cardiology, 93(1), 40-44.
    Chen, S. R., Lee, Y. J., Chiu, H. W., & Jeng, C. (2007). Impact of glycemic control, disease duration, and exercise on heart rate variability in children with type 1 diabetes mellitus. Journal of the Formosan Medical Association, 106(11), 935-942.
    Chen, J., Thomson, P. D., Nolan, V., & Clarke, J. (2004). Age and sex dependent variations in the normal magnetocardiogram compared with changes associated with ischemia. Annals of Biomedical Engineering , 32(8), 1088-1099.
    Deen, D. (2004). Metabolic syndrome: Time for action. American Family
    Physician,69, 2875-2882.
    Demura, S., & Sato, S. (2007). Prediction of visceral fat area at the umbilicus level using fat mass of the trunk: The validity of bioelectrical impedance analysis. Journal of Sports Ssciences, 25(7), 823-833.
    Despres, J. P. (2007). Cardiovascular disease under the influence of excess visceral fat. Critical Pathways in Cardiology, 6(2), 51-59.
    Dinneen, S. F., & Gerstein, H. C. (1997). The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature. Archives of Internal Medicine, 157(13), 1413-1418.
    Eckel, R. H., Grundy, S. M., & Zimmet, P. Z. (2005). The metabolic syndrome. Lancet, 365(9468), 1415-1428.
    Finley, C. E., LaMonte, M. J., Waslien, C. I., Barlow, C. E., Blair, S. N., & Nichaman, M. Z. (2006). Cardiorespiratory fitness, macronutrient intake, and the metabolic syndrome: the Aerobics Center Longitudinal Study. Journal of the American Dietetic Association, 106(5), 673-679.
    Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., et al. (2007). Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. Journal of the American College of Cardiology, 49(4), 403-414.
    Gerstein, H. C., Mann, J. F., Yi, Q., Zinman, B., Dinneen, S. F., Hoogwerf, B., et al. (2001). Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. The journal of the American Medical Association(JAMA), 286(4), 421-426.
    Grundy, S. M. (2006). Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. Journal of the American College of Cardiology, 47(6), 1093-1100.
    Grundy, S. M., Brewer, H. B., Jr., Cleeman, J. I., Smith, S. C., Jr., & Lenfant, C. (2004). Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation, 109(3), 433-438.
    Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., et al. (2005). Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 112(17), 2735-2752.
    Hailer, B., Van Leeuwen, P., Sallner, D., Lange, S., & Wehr, M. (2000). Changes of QT dispersion in patients with coronary artery disease dependent on different methods of stress induction. Clinical cardiology. 23, 181-186.
    Han, T. S., McNeill, G., Seidell, J. C., & Lean, M. E. (1997). Predicting intra-abdominal fatness from anthropometric measures: the influence of stature. International Journal of Obesity and Related Metabolic Disorders, 21(7), 587-593.
    Hanninen, H., Takala, P., Korhonen, P., Oikarinen, L., Makijarvi, M., Nenonen, J., et al. (2002). Features of ST segment and T-wave in exercise-induced myocardial ischemia evaluated with multichannel magnetocardiography. Annals of Medicine, 34(2), 120-129.
    Hassinen, M., Lakka, T. A., Savonen, K., Litmanen, H., Kiviaho, L., Laaksonen, D. E., et al. (2008). Cardiorespiratory Fitness as a Feature of the Metabolic Syndrome in Older Men and Women: The DR's EXTRA Study. Diabetes Care.
    Heffernan, K. S., Jae, S. Y., & Fernhall, B. (2007). Heart rate recovery after exercise is associated with resting QTc interval in young men. Clinical Autonomic Research, 17(6), 356-363.
    Hottenrott, K., Hoos, O., & Esperer, H. D. (2006). Heart rate variability and physical exercise. Current status. Herz, 31(6), 544-552.
    Im, J. A., Lee, J. W., Shim, J. Y., Lee, H. R., & Lee, D. C. (2007). Association between brachial-ankle pulse wave velocity and cardiovascular risk factors in healthy adolescents. The Journal of Pediatrics, 150(3), 247-251.
    Isomaa, B. (2003). A major health hazard: the metabolic syndrome. Life Sciences, 73(19), 2395-2411.
    Kaplan, N. M. (1989). The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Archives of Internal Medicine, 149(7), 1514-1520.
    Katzmarzyk, P. T., Leon, A. S., Wilmore, J. H., Skinner, J. S., Rao, D. C., Rankinen, T., et al. (2003). Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Medicine and Science in Sports and Exercise, 35(10), 1703-1709.
    Kingwell, B. A. (2000). Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease. Official Publication of the Federation of American Societies for Experimental Biology, 14(12), 1685-1696.
    Laakso M. (1996). Insulin resistance and coronary heart disease. Current Opinion in Lipidology, 7, 217-226.
    Laaksonen, D. E., Lakka, H. M., Salonen, J. T., Niskanen, L. K., Rauramaa, R., & Lakka, T. A. (2002). Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care, 25(9), 1612-1618.
    Lakka, H. M., Laaksonen, D. E., Lakka, T. A., Niskanen, L. K., Kumpusalo, E., Tuomilehto, J., et al. (2002). The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. The Journal of the American Medical Association(JAMA), 288(21), 2709-2716.
    LaMonte, M. J., Barlow, C. E., Jurca, R., Kampert, J. B., Church, T. S., & Blair, S. N. (2005). Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome: a prospective study of men and women. Circulation, 112(4), 505-512.
    Lant, J., Stroink, G., ten Voorde, B., Horacek, B. M., & Montague, T. J. (1990). Complementary nature of electrocardiographic and magnetocardiographic data in patients with ischemic heart disease. Journal of electrocardiology. 23, 315-322.
    Lee, S. J., & Arslanian, S. A. (2007). Cardiorespiratory fitness and abdominal adiposity in youth. European Journal of Clinical Nutrition, 61(4), 561-565.
    Lehmann, E. D. (1999). Clinical value of aortic pulse-wave velocity measurement. Lancet, 354(9178), 528-529.
    Liao, D., Sloan, R. P., Cascio, W. E., Folsom, A. R., Liese, A. D., Evans, G. W., et al. (1998). Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study. Diabetes Care, 21(12), 2116-2122.
    Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., et al. (2004). Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation, 110(10), 1245-1250.
    Meigs, J. B. (2002). Epidemiology of the metabolic syndrome, 2002. The American Journal of Managed Ccare, 8(11 Suppl), S283-292; quiz S293-286.
    Min, K. B., Min, J. Y., Paek, D., & Cho, S. I. (2008). The impact of the components of metabolic syndrome on heart rate variability: using the NCEP-ATP III and IDF definitions. Pacing and clinical electrophysiology, 31(5), 584-591.
    Nagano, M., Kai, Y., Zou, B., Hatayama, T., Suwa, M., Sasaki, H., et al. (2004). The contribution of cardiorespiratory fitness and visceral fat to risk factors in Japanese patients with impaired glucose tolerance and type 2 diabetes mellitus. Metabolism, 53(5), 644-649.
    Nilsson, S. (2001). [Research contributions of Eskil Kylin]. Svensk medicinhistorisk tidskrift, 5(1), 15-28.
    Okura, T., Nakata, Y., Ohkawara, K., Numao, S., Katayama, Y., Matsuo, T., et al. (2007). Effects of aerobic exercise on metabolic syndrome improvement in response to weight reduction. Obesity (Silver Spring), 15(10), 2478-2484.
    Orchard, T. J., Temprosa, M., Goldberg, R., Haffner, S., Ratner, R., Marcovina, S., et al. (2005). The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Annals of Internal Medicine, 142(8), 611-619.
    Pagkalos, M., Koutlianos, N., Kouidi, E., Pagkalos, E., Mandroukas, K., & Deligiannis, A. (2007). Heart rate variability modifications following exercise training in type 2 diabetic patients with definite cardiac autonomic neuropathy. British Journal of Sports Medicine.
    Park, Y. W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003). The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Archives of Internal Medicine, 163(4), 427-436.
    Petersen, J. L., & McGuire, D. K. (2005). Impaired glucose tolerance and impaired fasting glucose--a review of diagnosis, clinical implications and management. Diabetes & Vascular Disease Research, 2(1), 9-15.
    Pyörälä, M., Miettinen, H., Laakso, M., & Pyörälä, K. (1998). Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Circulation, 98(5), 398-404.
    Pyörälä, M., Miettinen, H., Halonen, P., Laakso, M., & Pyörälä, K. (2000). Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arteriosclerosis, Thrombosis, and Vvascular Biology, 20(2), 538-544.
    Reaven, G. (2002). Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation, 106(3), 286-288.
    Reaven, G. M. (1993). Role of insulin resistance in human disease (syndrome X): an expanded definition. Annual Review of Medicine, 44, 121-131.
    Reaven, G. M. (1988). Banting lecture 1988. Role of insulin resistance in human disease. Diabetes, 37(12), 1595-1607.
    Rikli, R. E., & Jones, C. J. (2001) Senior fitness test manual . Champaign, IL: Human Kinetic.
    Salmenniemi, U., Ruotsalainen, E., Pihlajamaki, J., Vauhkonen, I., Kainulainen, S., Punnonen, K., et al. (2004). Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation, 110(25), 3842-3848.
    Smiley, T., Oh, P., & Shane, L. G. (2001). The relationship of insulin resistance measured with reliable indexes to coronary artery disease risk factors and outcomes: a systematic review. The Canadian Journal of Cardiology, 17, 797-805.
    Takala, P., Hanninen, H., Montonen, J., Korhonen, P., Makijarvi, M., Nenonen, J., et al. (2002). Heart rate adjustment of magnetic field map rotation in detection of myocardial ischemia in exercise magnetocardiography. Basic Research in Cardiology, 97(1), 88-96
    Tavarozzi, I., Comani, S., Del Gratta, C., Di Luzio, S., Romani, G. L., Gallina, S., et al. (2002). Magnetocardiography: current status and perspectives. Part II: Clinical applications. Italian Heart Journal, 3(3), 151-165.
    Tavarozzi, I., Comani, S., Del Gratta, C., Romani, G. L., Di Luzio, S., Brisinda, D., et al. (2002). Magnetocardiography: current status and perspectives. Part I: Physical principles and instrumentation. Italian Heart Journal, 3(2), 75-85.
    Van Leeuwen, P., Hailer, B., Lange, S., & Gronemeyer, D. (2003). Spatial distribution of repolarization times in patients with coronary artery disease. Pacing and Clinical Electrophysiology, 26(8), 1706-1714
    Van Popele, N. M., Grobbee, D. E., Bots, M. L., Asmar, R., Topouchian, J., Reneman, R. S., et al. (2001). Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke, 32(2), 454-460.
    Wakai, R. T., Leuthold, A. C., Wilson, A. D., & Martin, C. B. (1997). Association of fetal junctional rhythm and respiratory arrhythmia detected by magnetocardiography. Pediatric Ccardiology, 18(3), 201-203.
    Watkins, L. L., Sherwood, A., Feinglos, M., Hinderliter, A., Babyak, M., Gullette, E., et al. (2003). Effects of exercise and weight loss on cardiac risk factors associated with syndrome X. Archives of Internal Mmedicine, 163(16), 1889-1895.
    Wang, J., Ruotsalainen, S., Moilanen, L., Lepisto, P., Laakso, M., & Kuusisto, J. (2007). The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns. European Heart Journal, 28(7), 857-864.
    World Health Organisation Consultation. (1999). Definition, diagnosis and classification of diabetes mellitus and its complications: report of the World Health Organisation Consultation. Geneva: World Health Organisation.
    Yang, Y. C., Wu, J. S., Lu, F. H., Chang, W. C., Wu, C. H., & Chang, C. J. (2007). In addition to obesity and insulin resistance, microalbuminuria and diminished insulin secretion are linked with the metabolic syndrome in community-dwelling nondiabetic Taiwanese subjects. Diabetes Research and Clinical Practice, 76(1), 102-110.
    Yazici, M., Ozdemir, K., Altunkeser, B. B., Yazici, R., Kayrak, M., Ulgen, M. S., et al. (2007). Exercise Does Not Increase QTcmax and QTcd in Diabetic Patients with Autonomic Neuropathy. Pacing and Clinical Electrophysiology, 30(12), 1493-1498.
    Yokoyama, H., Kuramitsu, M., Kanno, S., Tada, J., Yokota, Y., & Kamikawa, F. (2007). Relationship between metabolic syndrome components and vascular properties in Japanese type 2 diabetic patients without cardiovascular disease or nephropathy. Diabetes Research and Clinical Practice, 75(2), 200-206.
    Zhu, S., St-Onge, M. P., Heshka, S., & Heymsfield, S. B. (2004). Lifestyle behaviors associated with lower risk of having the metabolic syndrome. Metabolism, 53(11), 1503-1511.
    Zhuravlev, Y. E., Rassi, D., Mishin, A. A., & Emery, S. J. (2002). Dynamic analysis of beat-to-beat fetal heart rate variability recorded by SQUID magnetometer: quantification of sympatho-vagal balance. Early Human Development, 66, 1-10.

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