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研究生： 陳宏銘
Hung-Ming Chen
論文名稱： 阿達瑪轉換在氣相層析質譜儀上的應用
pplications of Hadamard Transform to Gas Chromatography/Mass Spcectrometry
指導教授： 林震煌
Lin, Cheng-Huang
學位類別： 碩士
Master
系所名稱： 化學系
Department of Chemistry
論文出版年： 2008
畢業學年度： 96
語文別： 中文
中文關鍵詞： 阿達瑪 、氣相層析質譜儀
論文種類： 學術論文
相關次數： 點閱：226  下載：0 
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    • 本研究成功地將阿達瑪轉換技術應用在氣相層析質譜儀上。在氣相層析儀上改變進樣裝置，利用電磁閥控制空氣壓力進出，使其可達到多重進樣的效果。此進樣裝置可以根據阿達瑪序列準確地連續進樣，在此進樣模式下可獲得被編碼的層析圖。將此層析圖經由阿達瑪轉換後，可順利提高S/N值，且提高的倍數與理論上所得的理論值相接近。若以511或1023的矩陣進樣，更可提高S/N值約10倍。本實驗研究進樣壓力、進樣秒數、烘箱溫度等因素對於阿達瑪轉換的影響。兩種濫用藥物3,4-Methylenedioxy-N-methylamphetamine （3,4-MDMA）及N,N-dimethyltryptamine（DMT）則是本實驗的測試樣品。此外，本研究所發展的阿達瑪轉換—氣相層析質譜儀亦可應用於吸食毒品嫌犯尿液的檢測上。

    Successful application of the Hadamard transform (HT) technique to gas chromatography/mass spectrometry (GC/MS). Novel sample injection devices were developed to achieve multiple sample injections in GC instrument by using an electromagnetic valve to control the air pressure. The injection devices permitted successive injections precisely, resulting in clearly modulated chromatograms encoded by Hadamard matrices. After inverse Hadamard transformation of the encoded chromatogram, the signal-to-noise (S/N) ratios of the signals were substantially improved compared with those expected from theoretical values. The S/N ratios were enhanced ~10-fold in HT-GC/MS, using the matrices of 511 and 1023, respectively. This experiment considered the factors of the injection pressure, injection frequency and the temperature of oven that were affect the efficiency of Hadamard transformation. Two well known, abused drugs, 3,4-Methylenedioxy-N-methylamphetamine (3,4-MDMA) and N,N-dimethyltryptamine (DMT), were employed as model samples. The HT-GC/MS was successfully applied to the determination of drugs in the urine sample of a suspect.

    摘要……………………………………………………………………Ⅰ Abstract………………………………………………………………Ⅱ 目錄……………………………………………………………………Ⅲ 第一章 緒論 1-1 研究目的…………………………………………………………01 1-2 分析物簡介………………………………………………………02 1-2-1 苯乙胺類濫用藥物—3,4-MDMA………………………………02 1-2-2色胺類濫用藥物—DMT…………………………………………03 第二章 研究方法及原理 2-1 阿達瑪矩陣原理…………………………………………………04 2-1-1 矩陣(matrix)起源……………………………………………05 2-1-2 阿達瑪轉換法…………………………………………………06 2-1-3 LabVIEW操作程式……………………………………………13 2-1-4 阿達瑪轉換提高S/N值的理論值……………………………15 2-2 阿達瑪矩陣轉換在其他方面的應用……………………………18 2-2-1 在分析化學上的應用…………………………………………18 2-2-2 在其它方面上的應用…………………………………………21 第三章 研究儀器和藥品 3-1 實驗儀器…………………………………………………………23 3-1-1 氣相層析質譜法………………………………………………23 3-1-2 氣相層析儀……………………………………………………29 3-1-3 界面……………………………………………………………25 3-1-4 質譜儀…………………………………………………………25 3-1-5 資料處理………………………………………………………28 3-1-6 質譜儀校正……………………………………………………28 3-1-7 儀器及週邊設備列表…………………………………………30 3-2 實驗藥品列表……………………………………………………32 第四章 研究過程和結果討論 4-1 阿達瑪進樣裝置…………………………………………………34 4-1-1 標準品之配製…………………………………………………34 4-1-2 進樣端…………………………………………………………35 4-1-3 阿達瑪進樣最佳條件…………………………………………43 4-2 阿達瑪轉換數據前處理…………………………………………52 4-2-1 進樣頻率秒數設定……………………………………………52 4-2-2 數據處理………………………………………………………54 4-3 阿達瑪進樣與理論進樣比較……………………………………56 4-3-1 阿達瑪進樣與理論進樣比較…………………………………56 4-3-2 阿達瑪進樣與單點進樣比較…………………………………59 4-3-3 阿達瑪以不同序列進樣與轉換後比較………………………62 4-4 混合物阿達瑪進樣………………………………………………69 4-5 真實樣品分析……………………………………………………72 4-5-1 尿液的萃取……………………………………………………72 4-5-2 檢量線製作……………………………………………………74 4-5-3 人體尿液中毒品的偵測………………………………………78 第五章 結論和展望 5-1 最佳阿達瑪進樣條件方面………………………………………80 5-2 真實樣品分析方面………………………………………………80 5-3 應用與展望………………………………………………………81 論文發表………………………………………………………………82 參考資料………………………………………………………………83 附件︰期刊論文

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