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研究生: 卓邦彥
Cho, Pang-Yen
論文名稱: 多通道磁粒子造影系統開發與特性研究
The Development and Characteristization of Multichannel Magnetic Particle Imaging System
指導教授: 廖書賢
Liao, Shu-Hsien
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2015
畢業學年度: 103
語文別: 中文
論文頁數: 46
中文關鍵詞: 多通道磁粒子造影磁流體
論文種類: 學術論文
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  • 磁粒子造影系統可以藉由磁奈米粒子的磁化訊號得到磁流體分佈。傳統磁流體造影系統量測方式為利用磁鐵產生梯度場並在中心用激發線圈產生激發磁場並利用一組梯度接收線圈量測訊號,但是量測方法需要時間且需要足夠強的梯度場來造影,因此有造影空間較小的缺點。
    本研究旨在開發多通道磁粒子造影系統即利用多通道接收線圈擷取訊號,主要的量測方法為利用激發線圈產生範圍較大的均勻交流磁場,並將梯度接收線圈陣列置於其中並擷取訊號,而因為陣列梯度接收線圈平衡不易,所以我們使用強交流磁場(50 Oe)使磁流體開始飽和,並使磁化訊號的三倍頻成份增強。從頻譜觀察三倍頻訊號在此條件下三倍頻訊雜比較一倍頻大,因此主要量測三倍頻訊號。造影方法經由不同位置的接收線圈擷取到三倍頻訊號得出磁場分佈圖,再由磁場分佈圖使用MNE(Minimum-Norm Estimation)演算法,同步重建樣品分佈,產生即時影像。影像時間解析度可達100 毫秒,量測樣品空間解析度約為9 毫米,未來可以利用改善演算法增加造影的相似度以及改善線圈排列提高Z軸方向解析。

    第一章 緒論 1 第二章 實驗原理 5 2-1 磁流體特性 5 2-2擷取三倍頻訊號 6 2-3 最小範數估計演算法(Minimum-Norm Estimination) 8 第三章 實驗架構及實驗方法 10 3-1 整體架構與實驗方法 10 3-2.多通道梯度接收線圈設計與改進 12 第四章 實驗結果 15 4-1線圈匝數比較 15 4-2 一倍頻訊與三倍頻訊號實際測試 17 4.3 最小樣品量測試 18 4.3 改變不同相容係數比較 19 4-5 不同間距圓柱樣品比較 B、M、相似度 23 4-6 不同圖樣結果 B、M、相似度 27 4-7 即時影像 31 4-8 實驗改善 34 4-8.1 樣品分佈削減改善 34 4-8.2 激發線圈 37 4-8.3 中心線圈SNR 38 4-8.4 靜態圖樣量測 39 4-8.5 動態影像量測 40 第六章 結論 42 參考文獻 43

    1. Gleich, B., & Weizenecker, J. (2005). “Tomographic imaging using the nonlinear response of magnetic particles.” Nature, 435(7046), 1214-1217.

    2. Goodwill, P. W., Scott, G. C., Stang, P. P., & Conolly, S. M. (2009). “Narrowband magnetic particle imaging.” Medical Imaging, IEEE Transactions on, 28(8), 1231-1237.

    3. Goodwill, Patrick W., and Steven M. Conolly. "The x-space formulation of the magnetic particle imaging process: 1-D signal, resolution, bandwidth, SNR, SAR, and magnetostimulation." Medical Imaging, IEEE Transactions on 29.11 (2010): 1851-1859.

    4. Goodwill, P. W., Tamrazian, A., Croft, L. R., Lu, C. D., Johnson, E. M., Pidaparthi, R., ... & Conolly, S. M. (2011). “Ferrohydrodynamic relaxometry for magnetic particle imaging.” Applied Physics Letters, 98(26), 262502-262502.

    5. Goodwill, P. W., & Conolly, S. M. (2011). “Multidimensional x-space magnetic particle imaging.” Medical Imaging, IEEE Transactions on, 30(9), 1581-1590.

    6. Goodwill, Patrick W., et al. "An x-space magnetic particle imaging scanner." Review of Scientific Instruments 83.3 (2012): 033708-033708.

    7. Kratz, H., Eberbeck, D., Wagner, S., Schnorr, J., & Taupitz, M. (2012). “Tracer Development for Magnetic Particle Imaging.“ In Magnetic Particle Imaging (pp. 123-127). Springer Berlin Heidelberg.

    8. Weizenecker, J., Gleich, B., Rahmer, J., Dahnke, H., & Borgert, J. (2009). “Three-dimensional real-time in vivo magnetic particle imaging.” Physics in medicine and biology, 54(5), L1.

    9. Graeser, M., Biederer, S., Grüttner, M., Wojtczyk, H., Sattel, T. F., Tenner, W., ... & Buzug, T. M. (2012). “Determination of System Functions for Magnetic Particle Imaging. In Magnetic Particle Imaging (pp. 59-64).” Springer Berlin Heidelberg.

    10. Knopp, T., Sattel, T. F., Biederer, S., Rahmer, J., Weizenecker, J., Gleich, B., ... & Buzug, T. M. (2010). “Model-based reconstruction for magnetic particle imaging.” Medical Imaging, IEEE Transactions on, 29(1), 12-18.

    11. Knopp, T., Biederer, S., Sattel, T. F., Rahmer, J., Weizenecker, J., Gleich, B., ... & Buzug, T. M. (2010). “2D model-based reconstruction for magnetic particle imaging.” Medical physics, 37, 485.

    12. Biederer, S., Sattel, T., Knopp, T., Lüdtke-Buzug, K., Gleich, B., Weizenecker, J., ... & Buzug, T. M. (2009, January). “A spectrometer for magnetic particle imaging.” In 4th European Conference of the International Federation for Medical and Biological Engineering (pp. 2313-2316). Springer Berlin Heidelberg.

    13. Rahmer, J., Weizenecker, J., Gleich, B., & Borgert, J. (2009). Signal encoding in magnetic particle imaging: properties of the system function. BMC medical imaging, 9(1), 4.

    14. 顏雅侖,錳鋅鐵氧化物磁性流體之製備及分散研究,國立台灣成功大學資訊工程研究所碩士論文(2002)

    15. 磁性奈米粒子於生物醫學上之應用,物理雙月刊(廿八卷四期)2006年8月692

    16. 陳泂翰,磁流體交流磁化率隨頻率變化之研究,國立台灣師範大學光電科技研究所碩士論文(2009)

    17. Li, A.H. (2007). “ Using Infrared Thermal Image in the Evaluation of Carotid Stenosis” (Doctoral dissertation).

    18. Brody, W.R. (1982). “Digital subtraction angiography.” Nuclear Science, IEEE Transactions on, 29(3), 1176-1180.

    19. Gleich, B., Weizenecker, J., & Borget, J.(2008). “Experimental results on fast 2D-encoded magnetic particle Imaging.” Physics in medicine and biology, 53(6), N81.

    20. Bean, C. P., & Livingston, J. D. (1959). “Superparamagnetism. Journal of Applied Physics”, 30(4), S120-S129.

    21. Edelman, R. R., & Warach, S. (1993). Magnetic resonance imaging New England Journal of Medicine, 328(10), 708-716

    22. Bulte, J. W., Walczak, P., Gleich, B., Weizenecker, J., Markov, D. E., Aerts, H. C., …& Kuhn, M. (2011, March). “MPI cell tracking: what can we learn from MRI?”. In SPIE Medicine Imaging (pp. 79650Z-79650Z). International Society for Optics and Photonics.

    23. Bulte, J. W. M., Walczak, P., Bernard, S., Gleich, B., Weizenecker, J., Borgert, J., … & Boeve, H. (2010). “Developimg cellular MPI: initial experience.” In Magnetic Nanoparticles: Particle Science, Imaging Technology, and Clinical Applications: Proceedings of the First International Workshop on Magnetic Particle Imaging (p. 201). World Scientific.

    24. Wojtczyk, H., Haegele, J., Gruttner, M., Tenner, W., Bringout, G., Graeser, M., … & Buzug, T. M. (2010). Visualization of Instruments in interventional Magnetic Particle Imaging (iMPI): A Simulation Study on SPIO Labelings. In Magnetic Particle Imaging(pp. 167-172). Springer Berlin Heidelberg.

    25. Saburo Tanaka, H Fujita, Y Hatsukade, T Nagaishi, K Nishi, H Ota, T.Otani and S.Suzuki “A food contaminant detection system based on high-Tc SQUIDs” Supercond. Sci. Technol. 19 (2006) S280–S283

    26. M Liebl, U Steinhoff, F Wiekhorst, J Haueisen and L Trahms “Quantitative imaging of magnetic nanoparticles by magnetorelaxometry with multiple excitation coils” Phys. Med. Biol. 59 (2014) 6607–6620

    27. Yi Zhang, Hayaki Murata, Yoshimi Hatsukade, and Saburo Tanaka “Superparamagnetic nanoparticle detection using second harmonic of magnetization response” Review of Scientific Instruments 84, 094702 (2013); doi: 10.1063/1.4820447

    28. 楊謝樂“高靈敏度磁減量生醫檢測原理及應用” 台灣磁性技術協會會訊 51 期 APR 2010

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