本研究利用具有nitrile官能基隻鏈的(雙烯)三羰鐵錯合物,於 -78℃,一
大氣壓的一氧化碳下與LDA作用進行分子內環化反應,2小時後提高溫度到
室溫繼續反應6小時,加入酸終止反應,可得到一組非對掌性的[3.3.0]或
[4.3.0]雙環酮類產物。若改變反應條件,將具有官能基支鏈的(雙烯)三羰
鐵錯合物,在-78℃氮氣下與LDA作用反應2小時後,加入酸中止反應。因反
應路徑不同,除了可得到一組非對掌性的 [3.3.0]或[4.3.0]雙環酮類產
物,另外可以得到[3.2.0]或[4.2.0]雙環酮類產物。

It is interesting to use the acyclic (1,3-butadiene)-
tricarbonyliron complexes bearing cyano group side chains in
organic intramolecular cyclization reacyions. Reaction of LDA
with the iron complexes, at -78℃ under the atomosphere of
carbon monoxide for 2 hours, and at 25℃ for 6 hours, gives the
diastereomeric bicyclo[3.3.0]octanone and bicyclo- [4.3.0
]nonanone compounds after quench with acid. A different result
is obtained when the reaction of LDA with the iron complexes is
carried out at -78℃ under the nitrogen for 2 hours and
quenched with acid. It gives not only the diastereomeric
bicyclo[3.3.0]octanone and bicyclo- [4.3.0]nonanone compounds,
but also the products of bicyclo- [3.2.0]heptanone and
bicyclo[4.2.0]octanone systems.
It is interesting to use the acyclic (1,3-butadiene)-