過去本實驗室已經成功整合超導量子干涉元件（SQUID, superconducting quantum interference device）和預極化（prepolarization）技術在台大醫院架設低磁場核磁共振系統（Low-field NMR）並運用於腫瘤量測之應用。為了克服臨床檢驗中微量生物樣品量測上的困難，本研究將實驗系統的接收線圈最佳化，藉此提升系統的訊雜比（signal-to-noise ratio,SNR）以降低需要的檢體量。
　　在接收線圈的設計上，配合微量的樣品，將接收線圈的體積縮小，並使用不同匝數的接收線圈進行樣品檢測，比較其訊號強度，找出最佳的線圈匝數。此外更比較了梯度計與磁量計樣式的接收線圈，發現在少量樣品的檢測中，磁量計樣式的接收線圈具有較佳的訊雜比。最佳化後的接收線圈在量測0.1毫升的去離子水時SNR可達到18，較原先的系統提高了80 %。在腫瘤檢測的應用中，進行了微量的老鼠腫瘤與正常肝組織之縱向鬆弛時間（T1）之量測，可區別的最少樣品量達0.05克，符合臨床檢測中微量取樣的要求，具有臨床檢驗應用的潛力。

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