本研究以柳亞丙胺基酸(sal-L-ala)，柳亞苯丙胺基酸(sal-L-phe)及柳苯丙胺基酸(Sslh-L-phe)為主要配子，合成了三系列二價銅的錯合物：(1)[Cu(sal-L-ala)(L)]，(2)[cu(sal-L-phe)(L)]及(3)[Cu(salh-L-phe)(L)]。其中L為4-甲基口比啶(4mpy)，4-胺基口比啶(4apy)，4-二甲基胺基口比啶(dmap)，咪口坐(imH)，4-甲基咪口坐(4mimH)，4-苯甲基咪口坐(4phimH)及2,9-二甲基-1，10-二氮雜菲(neoc)。利用元素分析，紅外線光譜，紫外-可見光光譜，電子順磁光譜，圓形二色光光譜及X-光結構解析方法完成錯合物結構的鑑定及鍵結性質的探討。目前已完成 X-光單晶結構解析的二價銅錯合物有：
(1)cu(Sal-L-ala)(imH)
單斜晶系(monoclinic)，空間群為P21，其晶格常數：:
a=7.9862(6)A，b=9.9257(7)A，c=17．4768(7)A；β=100.256(1)°， V=1363.2(5)A3，Z=4，精算值R=0.0386，Rw=0.0364。
(2)Cu(Sal-L-ala)(neoc)
單斜晶系(monoclinic)，空間群為C2/c，其晶格常數：
a=28.012(18)A，b=12.205(3)A，C=12.535(3)A；β=92.04(4)°， V=283(3)A3，Z=8，精算值R=0.089，Rw=0.082。
(3)Cu(sal-L-phe)(dmap)
單斜晶系(monoclinic)，空間群為P21，其晶格常數︰
a=10.6440(19)A，b=8.7584(9)A，C=11.0929(15)A；β=97.213(15)°，V=1025.9(3)A3，Z=2，精算值R=0.028，Rw=0.030。
(4)Cu(sal-D-phe)(dmap)
單斜晶系(monoclinic)，空間群為P21，其晶格常數： a=10.6490(6)A， b=8.7685(5)A， c=11.0975(l5)A；β=97.l60(1)°， V=1028.2(4)A3， Z=2，精算值R=0.0358，Rw=0.0345。
(5)Cu(sal-L-phe)(4apy)
三斜晶系(thiclinic)，空間群為P1，其晶格常數：
a=8.3643(6)A， b=10.2286(7)A， C=11.06l8(7)A; α=95.169(0)°， β=98.869(1)°， γ=95.087(1)°， V=4283(3)A3，Z=2，精算值R=0.0342，Rw=0.0344。
(6)Cu(sal-L-phe)(neoc)
斜方晶系(orthorhombic)，空間群為 P212121，其晶格常數：
a=9.4665(6)A， b=10.2210(7)A， C=25.5289(17)A； V=2470.l(7) A3，Z=4，精算值R=0.0402，Rw=0.0309。
從上述晶體結構，EPR，UV-vis及CD光譜得知Cu(sal-L-ala)(L)及Cu(sal-L-phe)(L)系列結構為方形角錐，且經可見光及CD光譜高斯交疊解析，d軌域能量排列順序為：
dx2-y2＞＞dz2＞dyz＞dxy＞dxz
另外Cu(sal-L-ala)(4apy)及Cu(sal-L-ala)(4phimH)經可見光及高斯交疊解析在固態時為方形平面，其d軌域能量排列順序為：dx2-y2＞＞dyz＞dxy＞dxz＞dz2
而在Cu(salh-L-phe)(L)系列方面由EPR，UV-vis，CD光譜以及高斯交疊解析，此系列錯合物在液態時為方形平面，固態時為方形角錐，其d軌域能量排列順序為：
液態：dx2-y2＞＞dxy＞dyz＞dxz＞dz2
固態：dx2-y2＞＞dz2＞dxy＞dyz＞dxz

Mixed-ligand N-salicylidenealaninato, N-salicylidenephenylalaninato and N-(2-hydroxybenzyl)phenylalaninato copper(Ⅱ) complexes, Cu(sal-L- ala)(L), Cu(sal-L-phe)(L) and Cu(salh-L-phe)(L), have been synthesized, where L=4-methylpyridine (4mpy), 4-aminopyridine (4apy). 4- dimethylaminopyridine (dmap), imidazole (imH), 4-methyl-imidazole (4mimH), 2-methylimidazole (2mimH), 4-phenyl-imidazole (4phimH) or neocuproine (neoc). These complexes have been characterized by elemental analysis, UV-vis, CD, IR, and EPR spectroscopic measurements.
By using three-dimensional X-ray diffraction methods, the crystal and molecular structures of the following six complexes have been determined. The crystal data of these complexes are given below:
(1) Cu(sal-L-ala)(imH) monoclinic, space group P21, with a=7.9862(6)A, b=9.9257(7)A, c=17.4768(7)A; β=100.256(1)°, V=1363.2(5)A3, Z =4, R=0.0386 and Rw=0.0364.
(2) Cu(sal-L-ala)(neoc) monoclinic, space group C2/c, with a=28.012(18)A, b=12.205(3)A, c=12.535(3)A ;β =92.04(4)°,V=4283(3)A3, Z=8, R=0.089 and Rw=0.082.
(3) Cu(sal-L-phe)(dmap) monoclinic, space group P21, with a=10.6440(19)A, b=8.7584(9)A, c=11.0929(15)A ,β =97.213(15)°, V=1025.9(3)A3, Z=2, R=0.028 and Rw=0.030.
(4) Cu(sal-D-phe)(dmap) monoclinic, space group P21, witha=10.6490(6)A, b=8.7685(5)A, c=11.0975(15)A ；β= 97.160(1)°, V=1028.2(4)A3, Z=2, R=0.0358 and Rw=0.0345.
(5) Cu(sal-L-phe)(4apy) triclinic, space group P1, with a=8.3643(6)A, b=10.2286(7)A, c=11.0618(7)A α=95.169(0)°, β=98.869(1)°, γ=95.087(1)°, V=4283(3)A3, Z=2, R=0.0342 and Rw=0.0344.
(6) Cu(sal-L-phe)(neoc) orthorhombic, space group P212121, with a=9.4665(6)A, b=10.2210(7)A, c=25.5289(17)A; V=2470.1(7) A3 Z=4, R=0.0402 and Rw=0.0309.
Based on the X-ray structures, EPR, UV-vis and CD spectral data, the molecular structures of Cu(sal-L-ala)(L) and Cu(sal-L-phe)(L) complexes are square pyramidal, deduced from Gaussian analyses of the visible and CD spectra. The sequences of the d orbitals are assigned as:dx2-y2＞＞dz2＞dyz＞dxy＞dxz
There are two exceptions. The molecular structure of Cu(sal-L- ala)(4apy) and Cu(sal-L-ala)(4phimH), by visible spectral Gaussian analysis, are square planar. Their sequence of d orbitals is assigned as: dx2-y2＞＞dyz＞dxy＞dxz＞dz2
In the Cu(salh-L-phe)(L) series, by EPR, UV-vis, CD spectrum and Gaussian analysis, their structure are square planar in liquid state but square pyramidal in solid state. The sequences of d orbitals are assigned as: liquid state: dx2-y2＞＞dxy＞dyz＞dxz＞dz2 solid state: dx2-y2＞＞dz2＞dxy＞>dyz＞dxz