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Author: 洪嘉伶
Hung, Chia-Ling
Thesis Title: 非血基質三價鈷超氧化物、過氧氫化物之合成、鑑定及反應性之研究
Synthesis, Characterization and Reactivity of Non-Heme CoIII-Superoxo and -Hydroperoxo Complexes
Advisor: 李位仁
Lee, Way-Zen
Degree: 碩士
Master
Department: 化學系
Department of Chemistry
Thesis Publication Year: 2020
Academic Year: 108
Language: 中文
Number of pages: 53
Keywords (in Chinese): 鈷超氧化物鈷過氧氫化物碳氫鍵活化
Keywords (in English): Cobalt-superoxo, Cobalt-hydroperoxo, C-H bond activaction
DOI URL: http://doi.org/10.6345/NTNU202000737
Thesis Type: Academic thesis/ dissertation
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  • 第一章 緒論 1 1-1含金屬的蛋白及酵素研究素 1 1-1-1 含鐵氧合酶HPCD 1 1-1-2 含鐵非血基質酶α-KG-NHFe 3 1-1-3 細胞色素P450 (Cytochrome P450,CYPs) 5 1-1-4 博來黴素 (Bleomycin) 7 1-2 擬態錯合物研究 9 1-2-1 鐵錯合物 9 1-2-2 鈷錯合物 11 1-3 本實驗研究方向 13 第二章 實驗部分 2-1 實驗儀器、藥品及條件 15 2-1-1 儀器 15 2-1-2 溶劑 17 2-1-3 藥品 19 2-2實驗條件 23 2-2-1 非空氣敏感的實驗 23 2-2-2 空氣敏感的實驗 23 2-3鈷錯合物的合成 24 2-3-1 CoII(BDBP) (1) 的合成 24 2-3-2 CoII(BDBP)(O2˙) (2) 的合成 25 2-3-3 CoIII(BDBP)(OOH) (3) 的合成 25 第三章 結果與討論 3-1 鈷錯合物CoII(BDBP) (1) 之鑑定與分析 26 3-1-1 CoII(BDBP) (1) 之X-ray晶體結構分析 26 3-1-2 CoII(BDBP) (1) 之UV-vis吸收光譜分析 28 3-1-3 CoII(BDBP) (1) 之循環伏安法光譜分析 29 3-1-4 CoII(BDBP) (1) 之電子順磁共振光譜分析 30 3-2 鈷超氧化物CoIII(BDBP)(O2˙) (2) 之分析 31 3-2-1 CoIII(BDBP)(O2˙) (2) 之UV-vis吸收光譜分析 31 3-2-2 CoIII(BDBP)(O2˙) (2) 之電子順磁共振光譜分析 33 3-3 鈷超氧氫化物CoIII(BDBP)(OOH) (3) 之分析 34 3-3-1 CoIII(BDBP)(OOH) (3) 之UV-vis吸收光譜分析 34 3-3-2 鈷超氧化物CoIII(BDBP)(OOH) (3) 之1H NMR光譜分析 35 3-3-3 CoIII(BDBP)(OOH) (3) 之循環伏安法分析 36 3-4 CoIII(BDBP)(O2˙) (2) 之反應性探討 37 3-4-1 CoIII(BDBP)(O2˙) (2)與DHA的反應 37 3-4-2 CoIII(BDBP)(O2˙) (2)和HOTf反應 39 3-5 鈷過氧氫化物CoIII(BDBP(OOH) (3) 質子化光譜探討 41 3-5-1 [CoIII(BDBP)(O2˙…H+)](OTf) 與還原劑之光譜探討 41 3-5-2 CoIII(BDBP)(OOH) (3) 氧化之光譜探討 43 第四章 結論與展望 46 參考文獻 48 附錄 50

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