背景: 近年來心血管疾病的問題與日俱增，脈波傳導速率 (pulse wave velocity, PWV) 及脂締素 (adiponectin) 皆是臨床上用以預測心臟血管疾病的指標，同時脂締素於人體中具有抗發炎及減緩動脈粥狀硬化等作用，然而離心運動所誘發之發炎反應是否會改變脂締素濃度並且影響脈波傳導速率，以及脂締素與 PWV 的關係仍需進一步釐清。目的：探討單次下坡跑與離心阻力運動對脂締素及PWV的影響，以及了解脂締素與 PWV 之相關。方法：招募18名自願參與的健康男性為研究對象，並隨機分派至下坡跑組(EE組；n=9)與離心阻力運動組(RE組；n=9)，正式實驗前EE組需在跑步機上進行攝氧峰值 (VO2peak) 測驗；RE組則在斜式腿部推舉機接受下肢最大肌肉力量 (1RM) 測驗。接著讓EE組在跑步機上以75% VO2peak的強度進行一次30分鐘的下坡跑 (-10°) ；RE組則在斜式腿部推舉機上以120% 1RM 強度進行離心阻力運動(每組反覆次數6次，共計10組)。兩組別在運動前、運動後90分鐘、24及48小時檢測 PWV 與血清脂締素、肌酸激酶 (Creatine kinese, CK) 及C反應蛋白 (C-reactive protein, CRP) 濃度。結果：下坡跑與離心阻力運動組之平均CK值於運動後各時間點均顯著高於運動前 (p＜.05)，同時，平均PWV也於運動後24 (5.47 ± 0.59 m/s) 及48 (5.44 ± 0.68 m/s) 小時顯著高於運動前 (5.18 ± 0.47 m/s) (p＜.05)，但脂締素及CRP 濃度皆無顯著改變 (p＞.05)；而 PWV 與脂締素濃度變化量在運動後90分鐘呈顯著負相關 (r= -.501) (p＜.05)。兩組別在所有依變項上，於不同時間點均無顯著差異 (p＞.05)。結論: 單次下坡跑與離心阻力運動皆會引發肌肉損傷及動脈硬化指標─脈波傳導速率的顯著提升，但不會造成脂締素濃度的改變；因此從事下坡跑與離心阻力運動將可能導致短暫性中心動脈的發炎，而其途徑或許與脂締素無直接關係。

Background: with the increasing prevalence of cardiovascular disease in modern society, pulse wave velocity (PWV) and adiponectin are both predictive markers for cardiovascular diseases in clinical settings. Adiponectin has been found vessel- protective that could exert anti-inflammatory effects and ameliorate atherosclerosis. However, it is still unknown whether inflammatory responses induced by eccentric exercise would interact with adiponectin as well as PWV. Purpose: to determine the effects of muscle damage induced by acute downhill running and eccentric resistance exercise on adiponectin and PWV as well as the relationship between adiponectin and PWV. Methods: eighteen apparent healthy males were recruited to participate this study. Participants were randomly assigned into downhill running (EE, n=9) and eccentric resistance exercise (RE, n=9) groups. Maximal oxygen uptake (VO2peak= 50.5 ± 7.6 ml/kg/min) of EE and one prepetition maximum of inclined leg press (1RM= 222.4 ± 55.2 kg) were determined prior to experiment. EE group performed 30 minutes of the downhill running at -10° of slope that could elicit 75% of individual VO2peak whereas RE group performed 120% 1RM eccentric contractions for 6 reps × 10 sets. PWV, serum adiponectin, creatine kinese (CK), and C-reactive protein (CRP) were measured pre-exercise, 90 minutes, 24 and 48 hours post-exercise. Results: CK of EE and RE group were significantly higher than the pre-exercise (p＜.05); PWV of two groups were also significantly higher on 24 (5.47 ± 0.59 m/s) and 48 hours post-exercise (5.44 ± 0.68 m/s) as compared to pre-exercise (5.18 ± 0.47 m/s) (p＜.05) respectively. Compared with pre-exercise, adiponectin and CRP were no altered after performing eccentric exercise (p＞.05). However, PWV was negative correlated with adiponectin on 24 hours post-exercise (r= -.501) (p＜.05). There were no significant differences among groups in all dependent variables (p＞.05). Conclusion: muscle damage induced by an acute bout of downhill running and eccentric resistance exercise both increased PWV, but did not altered adiponectin response. This transient aortic arterial inflammatory may not directly relate to adiponectin.

內政部(2011)。內正統計通報。2011年11月12日，取自內政部統計處
http://sowf.moi.gov.tw/stat/week/week10040.doc

吳家慶(2005)。不同強度動態恢復對損傷肌肉之功能及跑步經濟性的影響。
未出版碩士論文，國立臺灣師範大學，臺北市。

陳忠慶(2004)。運動引起肌肉損傷的原因之探討。運動生理暨體能學報，1，
19-32。

陳姿吟(譯)(2007)。精篇圖解生理學。臺北市：合記。(Ward, J. P.,
Clark, R. W., & Linden, R. W. A., 2004)

衛生署(2011)。民國99年死因結果摘要表。2011年11月12日，取自行政院
衛生署http://www.doh.gov.tw/CHT2006/DM/DM2_2_p02.aspx?
class_no=440&now_fod_list_no=11962&level_no=4&doc_no=
81294

American College of Sports Medicine. (2006). ACSM’s
guideline for exercise testing and prescription.
Baltimore : Lippincott Williams and Wilkins.

Asmar, R., Benetos, A., Topouchian, J., Laurent, P.,
Pannier, B., Brisac, A. M., & Levy, B. I. (1995).
Assessment of arterial distensibility by automatic
pulse wave velocity measurement :validation and
clinical application studies. Hypertension, 26(3), 485-
490.

Barnes, J. N., Trombold, J. R., Dhindsa, M., Lin, H. F., &
Tanaka, H. (2010). Arterial stiffening following
eccentric exercise-induced muscle damage. Journal of
Applied Physiology, 109(4), 1102-1108.

Berggren, J. R., Hulver, M. W., & Houmard, J. A. (2005).
Fat as an endocrine organ: influence of exercise.
Journal of Applied Physiology, 99(2), 757-764.

Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar,
M. E. (1999). Aortic pulse wave velocity as a marker of
cardiovascular risk in hypertensive patients. Journal
of Hypertension, 33(5), 1111-1117.

Blacher, J., & Safar, M. E. (2005). Large-artery stiffness,
hypertension and cardiovascular risk in older patients.
Nature Clinical Practice Cardiovascular Medicine, 2(9),
450-455.

Borg, G. A. (1982). Psychophysical bases of perceived
exertion. Medicine and Science in Sports and Exercise,
14(5), 377-381.

Bruce, R. A., & Dehn, M. M. (1972). Longitudinal variations
in maximal oxygen intake with age and activity. Journal
of Applied Physiology, 33(6), 805-807.

Byrne, C., & Eston, R. (2002). Maximal-intensity isometric
and dynamic exercise performance after eccentric muscle
actions. Journal of Sports Sciences, 20(12), 951-959.

Chen, H. L., & Chen, C. C. (2004). Effects of a single bout
of intensive eccentric contractions at varying
repetitions on muscle damage. Annual Journal of
Physical Education and Sports Science, (4), 103-117.

Cortez-Cooper, M. Y., DeVan, A. E., Anton, M. M., Farrar,
R. P., Beckwith, K. A., Todd, J. S., & Tanaka, H.
(2005). Effects of high intensity resistance training
on arterial stiffness and wave reflection in women.
American Journal of Hypertension, 18(7), 930-934.

Coutinho, T., Rooke, T. W., & Kullo, I. J. (2011). Arterial
dysfunction and functional performance in patients with
peripheral artery disease: A review. Vascular Medicine,
16(3), 203-211.

Cruickshank, J. M., & Smith, J. C. (1989). The beta-
receptor, atheroma and cardiovascular damage.
Pharmacology and Therapeutics, 42(3), 385-404.

Deepa, S. S., & Dong, L. Q. (2009). APPL1: Role in
adiponectin signaling and beyond. American Journal of
Physiology-Endocrinology and Metabolism, 296(1), E22-
E36.

DeVan, A. E., Anton, M. M., Cook, J. N., Neidre, D. B.,
Cortez-Cooper, M. Y., & Tanaka, H. (2005). Acute
effects of resistance exercise on arterial compliance.
Journal of Applied Physiology, 98(6), 2287-2291.

Diez, J. J., & Iglesias, P. (2003). The role of the novel
adipocyte-derived hormone adiponectin in human disease.
European Journal of Endocrinology, 148(3), 293-300.

Drexel, H., Saely, C. H., Langer, P., Loruenser, G., Marte,
T., Risch, L., & Aczel, S. (2008). Metabolic and anti-
inflammatory benefits of eccentric endurance exercise -
A pilot study. European Journal of Clinical
Investigation, 38(4), 218-226.

Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F.,
Heintze, U., Janke, J., & Sharma, A. M. (2003).
Association between adiponectin and mediators of
inflammation in obese women. American Diabetes
Association, 52(4), 942-947.

Ferguson, M. A., White, L. J., McCoy, S., Kim, H. W.,
Petty, T., & Wilsey, J. (2004). Plasma adiponectin
response to acute exercise in healthy subjects.
European Journal of Applied Physiology, 91(2-3), 324-
329.

Fernandez-Real, J. M., Lopez-Bermejo, A., Casamitjana, R.,
& Ricart, W. (2003). Novel interactions of adiponectin
with the endocrine system and inflammatory parameters.
Journal of Clinical Endocrinology and Metabolism, 88
(6), 2714-2718.

Fitzgerald, G. K., Rothstein, J. M., Mayhew, T. P., & Lamb,
R. L. (1991). Exercise-Induced muscle soreness after
concentric and eccentric isokinetic
contractions.Physical Therapy, 71(7), 505-513.

Han, S. H., Quon, M. J., Kim, J., & Koh, K. K. (2007).
Adiponectin and cardiovas-cular disease - Response to
therapeutic interventions. Journal of the American
College of Cardiology, 49(5), 531-538.

Heffernan, K. S., Collier, S. R., Kelly, E. E., Jae, S. Y.,
& Fernhall, B. (2007). Arterial stiffness and
baroreflex sensitivity following bouts of aerobic and
resistance exercise. International Journal of Sports
Medicine, 28(3), 197-203.

Jurimae, J., Hofmann, P., Jurimae, T., Maestu, J., Purge,
P., Wonisch, M., & von Duvillard, S. P. (2006). Plasma
adiponectin response to sculling exercise at individual
anaerobic threshold in college level male rowers.
International Journal of Sports Medicine, 27(4), 272-
277.

Jurimae, J., Purge, P., & Jurimae, T. (2005). Adiponectin
is altered after maximal exercise in highly trained
male rowers. European Journal of Applied Physiology,93
(4), 502-505.

Kingwell, B. A., Berry, K. L., Cameron, J. D., Jennings, G.
L., & Dart, A. M. (1997). Arterial compliance increases
after moderate-intensity cycling. American Journal of
Physiology-Heart and Circulatory Physiology, 273(5),
H2186-H2191.

Kobayashi, H., Ouchi, N., Kihara, S., Walsh, K., Kumada,
M., Abe, Y., & Matsuzawa, Y. (2004). Selective
suppression of endothelial cell apoptosis by the high
molecular weight form of adiponectin. Circulation
Research, 94(4), E27-E31.

Kraemer, R. R., Aboudehen, K. S., Carruth, A. A., Durand,
R. J., Acevedo, E. O., & Castracane, V. D. (2003).
Adiponectin responses to continuous and progressively
intense intermittent exercise. The Journal of the
Federation of American Societies for Experimental
Biology, 17(5), A943-A944.

Kraemer, R. R., & Castracane, V. D. (2007). Exercise and
humoral mediators of peripheral energy balance: Ghrelin
and adiponectin. Experimental Biology and Medicine, 232
(2), 184-194.

Lieber, R. L., & Friden, J. (2002). Mechanisms of muscle
injury gleaned from animal models. American Journal of
Physical Medicine and Rehabilitation, 81(11), S70-S79.

London, G. M., & Guerin, A. P. (1999). Influence of
arterial pulse and reflected waves on blood pressure
and cardiac function. American Heart Journal, 138(3),
220-224.

Maeda, S., Otsuki, T., Iemitsu, M., Kamioka, M., Sugawara,
J., Kuno, S., & Tanaka, H. (2006). Effects of leg
resistance training on arterial function in older men.
British Journal of Sports Medicine, 40(10), 867-869.

Mahmud, A., & Feely, J. (2005). Adiponectin and arterial
stiffness. American Journal of Hypertension, 18(12),
1543-1548.

Marinou, K., Tousoulis, D., Antonopoulos, A. S., Stefanadi,
E., & Stefanadis, C. (2010). Obesity and cardiovascular
disease: From pathophysiology to risk stratification.
International Journal of Cardiology, 138(1), 3-8.

McMiken, D. F., & Daniels, J. T. (1976). Aerobic
requirements and maximum aerobic power in treadmill and
track running. Medicine and Science in Sports and
Exercise, 8(1), 14-17.

Miyachi, M., Kawano, H., Sugawara, J., Takahashi, K.,
Hayashi, K., Yamazaki, K., & Tanaka, H. (2004).
Unfavorable effects of resistance training on central
arterial compliance - A randomized intervention study.
Circulation, 110(18), 2858-2863.

Nosaka, K., & Clarkson, P. M. (1996). Changes in indicators
of inflammation after eccentric exercise of the elbow
flexors. Medicine and Science in Sports and Exercise, 28
(8), 953-961.

Nosaka, K., Newton, M., & Sacc, P. (2002). Delayed-onset
muscle soreness does not reflect the magnitude of
eccentric exercise-induced muscle damage.Scandinavian
Journal of Medicine and Science in Sports, 12(6), 337-
346.

Okamoto, T., Masuhara, M., & Ikuta, K. (2006). Effects of
eccentric and concentric resistance training on
arterial stiffness. Journal of Human Hypertension, 20
(5), 348-354.

Paschalis, V., Nikolaidis, M. G., Giakas, G., Theodorou, A.
A., Sakellariou, G. K., Fatouros, I. G., & Jamurtas, A.
Z. (2010a). Beneficial changes in energy expenditure
and lipid profile after eccentric exercise in
overweight and lean women. Scandinavian Journal of
Medicine and Science in Sports, 20(1), e103-111.

Paschalis, V., Nikolaidis, M. G., Theodorou, A. A.,
Panayiotou, G., Fatouros, I. G., Koutedakis, Y., &
Jamurtas, A. Z. (2010b). A weekly bout of eccentric
exercise is sufficient to induce health-promoting
effects. Medicine and Science in Sports and Exercise, 43
(1), 64-73.

Peake, J., Nosaka, K., & Suzuki, K. (2005).Characterization
of inflammatory responses to eccentric exercise in
humans. Exercise Immunology Review, 11, 64-85.

Pischon, T., Girman, C. J., Hotamisligil, G. S., Rifai, N.,
Hu, F. B., & Rimm, E. B.(2004). Plasma adiponectin
levels and risk of myocardial infarction in men.The
Journal of the American Medical Association, 291(14),
1730-1737.

Punyadeera, C., Zorenc, A. H. G., Koopman, R., McAinch, A.
J., Smit, E., Manders, R., & van Loon, L. J. C. (2005).
The effects of exercise and adipose tissue lipolysis on
plasma adiponectin concentration and adiponectin
receptor expression in human skeletal muscle. European
Journal of Endocrinology, 152 (3), 427-436.

Roig, M., O'Brien, K., Kirk, G., Murray, R., McKinnon, P.,
Shadgan, B., & Reid, W. D. (2008). The effects of
eccentric versus concentric resistance training on
muscle strength and mass in healthy adults: A
systematic review with meta-analysis. British Journal
of Sports Medicine, 43(8), 556-568.

Sato, H., Hayashi, J., Harashima, K., Shimazu, H., &
Kitamoto, K. (2005). A population-based study of
arterial stiffness index in relation to cardiovascular
risk factors. Journal of Atherosclerosis and
Thrombosis, 12(3), 175-180.

Saxton, J. M., Donnelly, A. E., & Roper, H. P. (1994).
Indices of free-radical-mediated damage following
maximum voluntary eccentric and concentric muscular
work. European Journal of Applied Physiology and
Occupational Physiology, 68(3), 189-193.

Schwane, J. A., Johnson, S. R., Vandenakker, C. B., &
Armstrong, R. B. (1983). Delayed-onset muscular
soreness and plasma CPK and LDH activities after
downhill running. Medicine and Science in Sports and
Exercise, 15(1), 51-56.

Simpson, K. A., & Singh, M. A. (2008). Effects of exercise
on adiponectin: A systematic review. Journal of
Obesity, 16(2), 241-256.

Sung, S. H., Chuang, S. Y., Sheu, W. H., Lee, W. J., Chou,
P., & Chen, C. H. (2009). Relation of adiponectin and
high-sensitivity C-reactive protein to pulse-wave
velocity and N-terminal pro-B-type natriuretic peptide
in the general population. The American Journal of
Cardiology, 103(10), 1411-1416.

Thomas, S., Reading, J., & Shephard, R. J. (1992). Revision
of the physical-activity readiness questionnaire (Par
-Q). Canadian Journal of Sport Sciences-Revue
Canadienne Des Sciences Du Sport, 17(4), 338-345.

Totsuka, M., Nakaji, S., Suzuki, K., Sugawara, K., & Sato,
K. (2002). Break point of serum creatine kinase release
after endurance exercise. Journal of Applied
Physiology, 93(4), 1280-1286.

Vaiopoulos, A. G., Marinou, K., Christodoulides, C., &
Koutsilieris, M. (2012). The role of adiponectin in
human vascular physiology. International Journal of
Cardiology, 155(2), 188-193.

Vallejo, A. F., Schroeder, E. T., Zheng, L., Jensky, N. E.,
& Sattler, F. R. (2006). Cardiopulmonary responses to
eccentric and concentric resistance exercise in older
adults. Age and Ageing, 35(3), 291-297.

Varady, K. A., Bhutani, S., Church, E. C., & Phillips, S.
A. (2010). Adipokine responses to acute resistance
exercise in trained and untrained men. Medicine and
Science in Sports and Exercise, 42(3), 456-462.

Verma, S., Li, S. H., Badiwala, M. V., Weisel, R. D.,
Fedak, P. W. M., Li, R. K., & Mickle, D. A. G. (2002).
Endothelin antagonism and interleukin-6 inhibition
attenuate the proatherogenic effects of C-reactive
protein. Circulation, 105(16), 1890-1896.

Vlachopoulos, C., Dima, I., Aznaouridis, K., Vasiliadou,
C., Ioakeimidis, N., Aggeli, C., & Stefanadis, C.
(2005). Acute systemic inflammation increases arterial
stiffness and decreases wave reflections in healthy
individuals. Circulation, 112(14), 2193-2200.

Yang, W. S., Lee, W. J., Funahashi, T., Tanaka, S.,
Matsuzawa, Y., Chao, C. L., & Chuang, L. M. (2001).
Weight reduction increases plasma levels of an adipose-
derived anti-inflammatory protein, adiponectin. Journal
of Clinical Endocrinology and Metabolism, 86(8), 3815-
3819.

Youn, J. C., Kim, C., Park, S., Lee, S. H., Kang, S. M.,
Choi, D., & Jang, Y. (2011). Adiponectin and
progression of arterial stiffness in hypertensive
patients. International Journal of Cardiology, 1-4.

Zhu, W. D., Cheng, K. K. Y., Vanhoutte, P. M., Lam, K. S.
L., & Xu, A. M. (2008). Vascular effects of
adiponectin: molecular mechanisms and potential
therapeutic intervention. Clinical Science, 114(5-6),
361-374.