在運動或是體能訓練過程中，運動參與者因為不同運動型態、時間及負荷強度，造成免疫功能改變，這是許多研究者所關切的問題。目前以耐力性運動所做的生化相關研究，多以自行車或馬拉松賽跑等運動型態為主，因此本研探討直排輪環島運動對人體白血球數目及免疫球蛋白濃度之影響。本研究以9名健康男性（平均年齡：20.78 ± 2.22歲，溜齡：9.44 ± 2.13年，最大攝氧量：54.49 ± 5.87 ml•min-1•kg-1），進行連續七天的直排輪環島運動（全程953公里），並在環島出發前一天、第一天結束後、第四天出發前、第七天出發前、第七天結束後、結束後36小時、結束後10天，7個時間點進行採血，以比較總白血球、嗜中性球、淋巴球、單核球、免疫球蛋白A、免疫球蛋白G與免疫球蛋白M之差異，並記錄其上呼吸道感染機率，所得的數據，以重複量數單因子變異數分析，考驗其變異。結果發現連續七天的環島運動，其淋巴球、免疫球蛋白A、G、M，在第四、七天出發前，皆顯著低於出發前一天(p< .05)。其次，在環島運動的七天過程中，第一、七天運動後，其總白血球、嗜中性球、單核球數目比當日運動前顯著上升(p< .05)；但淋巴球數目顯著下降，只有在環島第七天才發生。但環島一周內、環島後一周內期間的上呼吸道感染率，雖有上升的情形，但未達統計上顯著差異(p> .05)。隨著環島天數增加，連續長時間耐力運動後，免疫細胞會有下降的趨勢，降低免疫力，因而疾病感染的比例可能增加。因此在從事類似的活動時，應該在運動的時間、強度、持續天數及運動過程中飲食的選擇上，要加以注意，以避免運動過程中或運動後的免疫力下降，而造成疾病的感染。

Many researchers concerned the change of immunity when we were undertaken different exercise or training in different forms, duration, load. We knew some biochemical researches about endurance exercises liked cycling and marathon, but there were few researches about in-line skating. Hence, the present studied was focused on clarifying the effects of In-line skating around the island on white blood cell counts and the concentration of immunoglobulin. 　Nine male subjects (age = 20.78 ± 2.22years, VO2max = 54.49 ± 5.87 ml•min-1•kg-1) engaged in 7-day In-line skating around the island (distance = 953 km). Blood sample were collected at the 1st, 4th, 7th day before exercise around the island, immediately exhaustive exercise at the 1st, 7th day, and 36 hours, 10 days after exercise. Compared with the variation in leukocyte count, neutrophil count, lymphocyte count, monocyte count, and in the concentration of immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM). The rates of upper respiratory tract infections (URTI) were recorded. Data were analyzed using repeated one-way ANOVA and Pair-Sample t test. Result: 1) Lymphocyte count, concentration of IgA, IgG, IgM at the 4th, 7th day were significant lower than the 1st day (p< .05) in the exercise of 7-day In-line skating around the island. 2) After the day around the island, leukocyte count, neutrophil count and monocyte count were higher than before significantly (p< .05), but lymphocyte count was lower significantly at the 7th day. 3) The rate of URTI increased in the exercise of 7-day In-line skating around the island and the next week after exercise, but the change were no significant. (p> .05) With the days around the island went by, the immune cell showed a tendency to fall and the immunity reduced after the long time and endurance exercise. Thus the ratio of infection may increase.

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