背景：有氧運動能改善動脈硬化指標－脈波傳導速率 (pulse wave velocity, PWV) 及血壓，而增補葡萄糖會導致高血糖使PWV及血壓上升。研究指出，正常血壓者進行有氧運動能抵消75g葡萄糖增補造成血壓及PWV的負面影響，不過，目前對於非正常血壓者及不同劑量葡萄糖增補下是否有相同效應仍有待釐清。目的：探討前期高血壓者至高血壓男性在單次有氧運動後增補不同劑量葡萄糖對踝臂脈波傳導速率 (brachial-ankle PWV, baPWV) 及血壓之效應。方法：招募12位無規律運動之前期高血壓至高血壓的成年男性並檢測65% 儲備心跳率。接著，以雙盲及平衡次序之實驗設計，在65% HRR強度跑步機運動30分鐘後立即增補0g (安慰劑；PT)、25g (25T)、75g (75T) 葡萄糖三種實驗處理，每次實驗處理間隔至少7天。baPWV、血壓及血流調節舒張功能 (flow-mediated dilation, FMD) 於運動前、運動後30、60、90及120分鐘檢測。結果：不同劑量葡萄糖處理的baPWV在運動前皆無差異 (p > .05)，75T之baPWV在運動後120分鐘顯著高於PT (p < .05)，但25T之baPWV與PT無差異。PT之baPWV在運動後60及90分鐘顯著低於運動前 (p < .05)；不同劑量葡萄糖處理的平均動脈壓 (mean arterial pressure, MAP) 在各時間點皆無差異，75T的MAP在運動前與後無差異，而25T的MAP在運動後60至120分鐘顯著低於運動前 (p < .05)，PT的MAP在運動後60及90分鐘顯著低於運動前 (p < .05)；不同劑量葡萄糖處理的FMD在運動前皆無差異 (p > .05)，但75T之FMD在運動後各時間點皆顯著低於PT及25T (p < .05)，而25T之FMD在運動後30至90分鐘顯著低於PT (p < .05)。PT之FMD在運動後各時間點皆顯著高於運動前 (p < .05)。結論：有氧運動後立即增補75g葡萄糖會造成baPWV和FMD短暫負面影響，以及抵消有氧運動後降低MAP的效益。當有氧運動後增補葡萄糖劑量降至25g能減少葡萄糖對FMD及baPWV造成的負面影響，並達到運動後降低MAP的效益。

Background: Aerobic exercise can improve pulse wave velocity (PWV) and blood pressure. On the other hand, glucose supplementation can lead to hyperglycemia, resulting in an increase in PWV and blood pressure. Studies have shown that aerobic exercise in individuals with normal blood pressure can counteract the negative effects of a 75g glucose supplementation on blood pressure and PWV. However, it remains unclear whether the same effects exist in men with prehypertension and hypertension or under different doses of glucose supplementation. Purpose: To examine the effects of difference dose in glucose intake on brachial-ankle PWV and blood pressure after exercise in men with prehypertension and hypertension. Methods: 12 sedentary adult males with prehypertension to hypertension was recruited, and test 65% heart rate reserve (HRR) before trails. All the Participants perform three treatments in a double-blind counterbalanced design that include 0 (placebo), 25 and 75 g of glucose ingestion immediately after perform 30 min of treadmill running at intensity of 65% HRR. Each treatment on separate 7 days at least. baPWV, blood pressure, and flow-mediated dilation would be measured at baseline and 30,60, 90 and 120 min post-exercise in all treatments. Results: baPWV did not differ significantly among different treatments at baseline (p > .05). baPWV after 75g glucose treatment was significantly higher than 0g glucose treatment at 120 min post-exercise (p < .05), but there was no significant difference in baPWV between 25g glucose treatment and 0g glucose treatment. baPWV of the 0g glucose treatment was significantly lower than baseline at 60 and 90 min post-exercise (p < .05). Mean arterial pressure (MAP) did not differ significantly among different treatments at any time point. MAP of the 75g glucose treatment showed no significant difference baseline and post-exercise, while the MAP of the 25g glucose treatment was significantly lower than baseline at 60 to 120 min post-exercise (p < .05). MAP of the 0g glucose treatment was significantly lower than baseline at 60 and 90 min post-exercise (p < .05). Flow-mediated dilation (FMD) did not differ significantly among different treatments baseline (p > .05). FMD of the 75g glucose treatment was significantly lower than the 0g and 25g glucose treatments at all post-exercise time points (p < .05), and FMD of the 25g glucose treatment was significantly lower than the 0g glucose treatment at 30 to 90 min post-exercise (p < .05). FMD of the 0g glucose treatment was significantly higher than baseline at all post-exercise time points (p < .05). Conclusion: 75g of glucose supplement immediately after aerobic exercise can cause short-term negative effects on baPWV and FMD, and it would offset aerobic exercise decrease MAP. The negative effects of glucose on FMD and baPWV could be reduced when the supplemental glucose dose was reduced to 25g after aerobic exercise, and lower MAP after aerobic exercise.

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