現有文獻記載的中藥製劑方法，都是在組成藥材成分中選取兩個為指標成分，利用HPLC進行品質評估，本研究旨在開發毛細管電泳（CE）的新分析方法。
本研究首先定量杏仁製劑中的苦杏仁?，因為苦杏仁?為一中性氰?，所以選用0.06M SDS(sodium dodecyl sulfate，十二烷基硫酸鈉)以0.04MNa2B4O7調整pH值，配成緩衝溶液，可在14分鐘內完成13種含杏仁製劑的苦杏仁?之定量，其回收率在98.2~100.1%之間，相對標準偏差是1.29%(intraday)和1.55%(inter-day)。
除了以常見的SDS為MECC（膠束電動力學毛細管層析，micellar electrokinetic chromatography）的介面活性劑外，我們也利用膽酸鹽（sodium cholate,SC）界面活性劑，以含60%的50mMSC，15mMNaH2PO4，4.25mMNa2B4O7溶液和40%的氰甲烷配成緩衝溶液分析含大黃的兩種製劑，可於20分鐘內同時定量三黃瀉心湯及小承氣湯中大黃的sennosideA 、B、emodine，黃連的berberine、palmatine，黃芩的baicalin，厚樸的magnolol、honokil，及枳實的naringin等藥材成分。SC配合有機溶劑可減少毛細管壁負電對berberine、palmatine等正離子的吸附，使吸收峰較為陡峭，另外SC以Na2B4O7及NaH2PO4調pH值配成的緩衝溶液，因可與帶酸性羧基或酚基等藥效成分，產生不同的互溶程度，而達到分離的目的。
CE及HPLC同時用於評估小承氣湯中多種指標成分，發現解析度良好圖形理想的成分含量，分析結果相當接近，但若不夠整潔時，就可能出現差異。整體而言，CE應是相當理想的分析工具。期望能藉此研究提供多元化的資訊，有助中藥品質提升及中藥現代化。

Evaluation method of Chinese medicinal preparation in the present literatures was usually performed by high-performance liquid chromatography (HPLC) using two components in the composite drug materials as indexing standards. This study deals with the use of capillary electrophoresis (CE) as an analytical tool to estimate the Chinese herbal drugs.
Amygdalin is a meutral nitrile glycoside and is known as the most important bioactive substance in Armeniacae Semen. It can be analyzed by CE with a buffer solution of 0.06M SDS (sodium dodecyl sulfate) and 0.04M Na2B4O7 within 14 minutes. Recoveries of this compound in various Armeniacae Semen-containing Chinese medicinal preparations were 98.2~100.1% and the relative standard deviations were 1.29% (intra-day) and 1.55% (inter-day) respectively.
Sodium cholate (SC) other than SDS also used as surfactant for micellar electrokinetic chromatography (MECC) in our research. Using this reagent, the contents of sennoside A, B and emokin of Rhei Rhizoma, berberine and palmatine of Coptidis Rhizoma, magnolol and honokiol of Magnoliae Cortex. and naringin of Aurantii Fructus Immaturus in Chinese medicinal preparations namely San-huang-hsieh-hsin-tang and Hsiao cheng-chi-tang could be determined simultaneously within 20 minutes. With the use of SC and organic modifier, the adsorption between cations such as berberine and palmatine, etc. and anions of the capillary wall could be minimized, and thus sharpened the absorption peaks. Meanwhle, owing to the differences in solubility of various compounds with this surfactant, a buffer solution consisting of SC, NaH2PO4 and Na2B4O7 could be thus used to analyze the bioactive components as mentioned above.
From the assessment of various indexing standards of Hsiao cheng-chi-tang using CE and HPLC, we found that both CE and HPLC could give an identical results only if the peak was neat and ideal with good resolution in the chromatogram. In whole, CE is an ideal analysis instrument for Chinese medicinal preparations.