中文摘要
目的：本研究的主要目的為比較身體活動量不同之肥胖中年男性，其心磁圖特性及與心肺功能之差異。方法：本研究招募80位年齡介於45-55歲之中年男性，其中27位體脂肪大於25%，每週身體活動量小於800kcal為低身體活動量組 ( FL組)；另有19位體脂肪大於25%，每週身體活動量大於1500kcal為高身體活動量組 ( FH組)；以及34位體脂肪小於20%且無規律運動習慣者為對照組 (NN組)。所有受試者均接受身體組成和心磁圖測量以及六分鐘走路測驗。所得資料以單因子變異數分析(one-way ANOVA)考驗各組有無顯著差異，顯著水準訂為p<.05，並以皮爾遜積差相關分析心肺功能與心磁圖參數之相關性。結果：1. NN組之六分鐘走路測驗( 733.5±83.4公尺 )顯著優於FH組( 688.9±68.1公尺 )與FL組( 634.0±68.0公尺 )。2. FL組之心磁圖參數SIQTc ( 0.36±0.07 )顯著高於NN組( 0.27±0.04 )與FH組( 0.25±0.05 )，而FL組QTc dispersion值 ( 106.65±14.79 )顯著高於NN組( 83.77±10.63 )與FH組( 86.63±10.61 )；三組之B(x,y)值無顯著差異( NN組0.391±0.028, FL組0.398±0.03, FH組 0.397±0.026 )，而α角亦無顯著差異( NN組100.99±64.48, FL組 116.64±10.52, FH組124.17±13.26 )。3.心肺功能與心磁圖參數呈現負相關(r值介於-.002至-.397之間)，心肺功能與SIQTc、QTc dispersion、B(x,y)亦呈顯著相關 (p<.05)。結論：不論身體活動量高低之肥胖中年男性的心肺功能較差，而心磁圖參數顯示肥胖且身體活動量低者之心臟功能較差。

PURPOSE: The main purpose of this study was to compare the characteristics of magnetocardiography (MCG) and cardiovascular endurance between fat people of middle age who have high physical activity and the ones who don’t. METHODS: There were 80 middle age males (age between 45 and 55) to participate in this research voluntarily. According to the set rules, they fall into three groups, fat people with low-physical activity (Group FL, n=25, Body Fat>25% physical activity less than 800 kcal per week.), fat people with high-physical activity (Group FH, n=19, Body Fat>25% physical activity more than 1500 kcal per week.), and normal body fat with non-exercise (Group NN, n=34, Body Fat<20%) or the control group. All the subjects were measured for the values of body composition, six minutes walk test cardiovascular endurance, and MCG. The obtained data were analyzed by SPSS for Windows 16.0 to undergo the one-way ANOVA to test for the differences among those groups. Through the analysis of Pearson’s product-moment correlation, the correlation between values of endurance capability and MCG was found. RESULTS: 1. The distance of walking six minutes for of Group NN (733.5±83.4meters) are significantly longer than that of Group FL (634.0±68.0 meters) and that of Group FH (688.9±63.1 meters). 2. The MCG result of SIQTc shows Group FL (0.36±0.07) are significant more than that of Group FH(0.25±0.05) and that of Group NN (0.27±0.04); the result of QTc dispersion shows Group FL (106.65±14.79) are significantly higher than that of Group FH(86.63±10.61) and that of Group NN (83.77±10.63); there is no difference among the three groups for the B(x,y), 0.391±0.028 for Group NN, 0.398±0.03 for Group FL, and 0.397±0.026 for Group FH.; there is no difference among the three groups for the α-angle, 100.99±64.48 for Group NN, 116.64±10.52 for Group FL, and 124.17±13.26 for Group FH. 3. Cardiovascular endurance is negatively correlated with the parameter of MCG such as SIQTc, QTc dispersion, B(x,y), and α-angle (values of r are between -.002 and -.397). The correlation of endurance capability and SIQTc, QTc dispersion and B(x,y) reaches the evident correlation of P<.05. CONCLUSION: Group NN have better cardiovascular endurance than Group FL and Group FH because the former have lower body fat; the result of MCG shows Group FL are closely linked to a poorer cardiac function.

壹、中文部份

行政院衛生署（1997）：行政院衛生署86年統計資料。台北市：衛生
署。

卓俊辰(1986)。體適能—健身運動處方的理論與實際。台北市：國立
臺灣師範大學體育學會。

吳秉樺（2005）。低溫SQUID應用於人體心臟磁場測量之研究。未出版之碩士論文，台北市，國立台灣師範大學光電科技研究所。

洪斌峰（2006）。超導量子干涉心磁儀應用於高血脂兔子心臟心磁圖與生理學的研究。未出版之碩士論文，台北市，國立台灣師範大學光電科技研究所。

高美丁、曾明淑、葉文婷、張瑛紹、潘文涵（1998）：台灣地區居民體位及肥胖狀況，1993-1996年國民營養健康狀況變遷調查結果，行政院衛生署。

許靜宜（2007）。十週深水跑步訓練對女性中老年人心肺適能與心磁圖之影響。未出版之碩士論文，台北市，國立台灣師範大學體育學系。

陳相榮（1988），運動生理學，台中：精華出版社。

郭家驊、陳九州、陳志中（2000）。運動與肥胖專論。北體學報，7期，
180-192頁。

蔡明成（2007）。心磁圖用於心肌缺氧特性之研究。未出版之碩士論文，台北市，國立台灣師範大學光電科技研究所。

貳、英文部分

American College of Sports Medicine Position Stand. Exercise and physical activity for older adults. (1998). Medicine and science in sports and exercise, 30(6), 992-1008.
Barauna, V. G., Junior, M. L., Costa Rosa, L. F., Casarini, D. E., Krieger, J. E., & Oliveira, E. M. (2005). Cardiovascular adaptations in rats submitted to a resistance-training model. Clinical and experimental pharmacology & physiology, 32(4), 249-254.
Blomqvist, C. G., & Saltin, B. (1983). Cardiovascular adaptations to physical training. Annual Review of Physiology, 45, 169-189.
Bortz, W. M., 2nd. (2000). Encouraging physical fitness for older people. Journal of the American Geriatrics Society, 48(8), 1021.
Bottini, P., Tantucci, C., Scionti, L., Dottorini, M. L., Puxeddu, E., Reboldi, G., et al. (1995). Cardiovascular response to exercise in diabetic patients: influence of autonomic neuropathy of different severity. Diabetologia, 38(2), 244-250.
Brehm, B. A. (1988). Elevation of metabolic rate following exercise. Implications for weight loss. Sports medicine, 6(2), 72-78.
Chen, Thomson, P. D., Nolan, V., & Clarke, J. (2004). Age and sex dependent variations in the normal magnetocardiogram compared with changes associated with ischemia. Annals of Biomedical Engineering, 32(8), 1088-1099.
Chen, K. Y., Acra, S. A., Donahue, C. L., Sun, M., & Buchowski, M. S. (2004). Efficiency of walking and stepping: relationship to body fatness. Obesity research, 12(6), 982-989.
Chun, D. M., Corbin, C. B., & Pangrazi, R. P. (2000). Validation of criterion-referenced standards for the mile run and progressive aerobic cardiovascular endurance tests. Research quarterly for exercise and sport, 71(2), 125-134.
Denke, M. A. (1996). Lipids, estrogen status, and coronary heart disease risk in women. Medicine and science in sports and exercise, 28(1), 13-14.
Ebeling, P., Bourey, R., Koranyi, L., Tuominen, J. A., Groop, L. C., Henriksson, J., et al. (1993). Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. The Journal of clinical investigation, 92(4), 1623-1631.
Ekblom, B. (1970). Effect of physical training on circulation during prolonged severe exercise. Acta physiologica Scandinavica, 78(2), 145-158.
Elrick, H., Yearwood-Drayton, V., Arai, Y., & Morris, H. G. (1964). Hormonal Content of Human Pituitaries from Embalmed Bodies. The Journal of clinical endocrinology and metabolism, 24, 910-914.
Enzi, G., Gasparo, M., Biondetti, P. R., Fiore, D., Semisa, M., & Zurlo, F. (1986). Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography. The American journal of clinical nutrition, 44(6), 739-746.
Greiwe, J. S., Holloszy, J. O., & Semenkovich, C. F. (2000). Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling. Journal of Applied Physiology, 89(1), 176-181.
Grundy, S. M., Blackburn, G., Higgins, M., Lauer, R., Perri, M. G., & Ryan, D. (1999). Physical activity in the prevention and treatment of obesity and its comorbidities: evidence report of independent panel to assess the role of physical activity in the treatment of obesity and its comorbidities. Medicine and science in sports and exercise, 31(11), 1493-1500.
Hänninen, H., Takala, P., Mäkijärvi, M., Montonen, J., Korhonen, P., Oikarinen, L., et al. (2000). Detection of exercise-induced myocardial ischemia by multichannel magnetocardiography in single vessel corronary artery disease. Annals of Noninvasive Electrocardiography, 5, 147-157.
Hagberg, J. M., Hickson, R. C., Ehsani, A. A., & Holloszy, J. O. (1980). Faster adjustment to and recovery from submaximal exercise in the trained state. Journal of applied physiology: respiratory, environmental and exercise physiology, 48(2), 218-224.
Hanninen, H., Takala, P., Korhonen, P., Oikarinen, L., Makijarvi, M., Nenonen, J., et al. (2002). Features of ST segment and T-wave in exercise-induced myocardial ischemia evaluated with multichannel magnetocardiography. Annals of medicine, 34(2), 120-129.
Hanninen, H., Takala, P., Makijarvi, M., Korhonen, P., Oikarinen, L., Simelius, K., et al. (2001). ST-segment level and slope in exercise-induced myocardial ischemia evaluated with body surface potential mapping. The American journal of cardiology, 88(10), 1152-1156.
Hanninen, H., Takala, P., Makijarvi, M., Montonen, J., Korhonen, P., Oikarinen, L., et al. (2001). Recording locations in multichannel magnetocardiography and body surface potential mapping sensitive for regional exercise-induced myocardial ischemia. Basic research in cardiology, 96(4), 405-414.
Hardman, A. E., & Hudson, A. (1994). Brisk walking and serum lipid and lipoprotein variables in previously sedentary women--effect of 12 weeks of regular brisk walking followed by 12 weeks of detraining. British journal of sports medicine, 28(4), 261-266.
Haykowsky, M. J., Gillis, R., Quinney, A., Ignaszewski, A. P., & Thompson, C. R. (1998). Left ventricular morphology in elite female resistance-trained athletes. The American journal of cardiology, 82(7), 912-914.
Haykowsky, M. J., Teo, K. K., Quinney, A. H., Humen, D. P., & Taylor, D. A. (2000). Effects of long term resistance training on left ventricular morphology. The Canadian journal of cardiology, 16(1), 35-38.
Hickson, R. C., Hagberg, J. M., Ehsani, A. A., & Holloszy, J. O. (1981). Time course of the adaptive responses of aerobic power and heart rate to training. Medicine and science in sports and exercise, 13(1), 17-20.
Hilsted, J., Galbo, H., & Christensen, N. J. (1980). Impaired responses of catecholamines, growth hormone, and cortisol to graded exercise in diabetic autonomic neuropathy. Diabetes, 29(4), 257-262.
Hilsted, J., Galbo, H., Christensen, N. J., Parving, H. H., & Benn, J. (1982). Haemodynamic changes during graded exercise in patients with diabetic autonomic neuropathy. Diabetologia, 22(5), 318-323.
Hinchcliff, K. W., Constable, P. D., Farris, J. W., Schmidt, K. E., & Hamlin, R. L. (1997). Electrocardiographic characteristics of endurance-trained Alaskan sled dogs. Journal of the American Veterinary Medical Association, 211(9), 1138-1141.
Iacobellis, G., Ribaudo, M. C., Leto, G., Zappaterreno, A., Vecci, E., Di Mario, U., et al. (2002). Influence of excess fat on cardiac morphology and function: study in uncomplicated obesity. Obesity research, 10(8), 767-773.
Karason, K., Wallentin, I., Larsson, B., & Sjostrom, L. (1997). Effects of obesity and weight loss on left ventricular mass and relative wall thickness: survey and intervention study. British Medical Journal (Clinical research ed, 315(7113), 912-916.
Karason, K., Wallentin, I., Larsson, B., & Sjostrom, L. (1998). Effects of obesity and weight loss on cardiac function and valvular performance. Obesity research, 6(6), 422-429.
Kearns, C. F., McKeever, K. H., John-Alder, H., Abe, T., & Brechue, W. F. (2002). Relationship between body composition, blood volume and maximal oxygen uptake. Equine veterinary journal(34), 485-490.
Kehayias, J. J., Fiatarone, M. A., Zhuang, H., & Roubenoff, R. (1997). Total body potassium and body fat: relevance to aging. The American journal of clinical nutrition, 66(4), 904-910.
Kominis, I. K., Kornack, T. W., Allred, J. C., & Romalis, M. V. (2003). A subfemtotesla multichannel atomic magnetometer. Nature, 422(6932), 596-599.
Lexell, J., Taylor, C. C., & Sjostrom, M. (1988). What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. Journal of the neurological sciences, 84(2-3), 275-294.
Liao, S. H., Hsu, S. C., Lin, C. C., Horng, H. E., Chen, J. C., Chen, M. J., et al. (2003). High-T-c SQUID gradiometer system for magnetocardiography in an unshielded environment. Superconductor Science & Technology, 16(12), 1426-1429.
Mauriege, P., Prud'Homme, D., Marcotte, M., Yoshioka, M., Tremblay, A., & Despres, J. P. (1997). Regional differences in adipose tissue metabolism between sedentary and endurance-trained women. The American journal of physiology, 273(3 Pt 1), E497-506.
Morricone, L., Malavazos, A. E., Coman, C., Donati, C., Hassan, T., & Caviezel, F. (2002). Echocardiographic abnormalities in normotensive obese patients: relationship with visceral fat. Obesity research, 10(6), 489-498.
Novak, L. P. (1972). Aging, total body potassium, fat-free mass, and cell mass in males and females between ages 18 and 85 years. Journal of gerontology, 27(4), 438-443.
Ozcelik, O., Aslan, M., Ayar, A., & Kelestimur, H. (2004). Effects of body mass index on maximal work production capacity and aerobic fitness during incremental exercise. Physiological research 53(2), 165-170.
Pacy, P. J., Webster, J., & Garrow, J. S. (1986). Exercise and obesity. Sports medicine (Auckland, N.Z, 3(2), 89-113.
Pascual, M., Pascual, D. A., Soria, F., Vicente, T., Hernandez, A. M., Tebar, F. J., et al. (2003). Effects of isolated obesity on systolic and diastolic left ventricular function. Heart (British Cardiac Society), 89(10), 1152-1156.
Pedersen, E. M., Stenbog, E. V., Frund, T., Houlind, K., Kromann, O., Sorensen, K. E., et al. (2002). Flow during exercise in the total cavopulmonary connection measured by magnetic resonance velocity mapping. Heart (British Cardiac Society), 87(6), 554-558.
Pelliccia, A., Spataro, A., Caselli, G., & Maron, B. J. (1993). Absence of left ventricular wall thickening in athletes engaged in intense power training. The American journal of cardiology, 72(14), 1048-1054.
Pesola, K., Nenonen, J., Fenici, R., Lotjonen, J., Makijarvi, M., Fenici, P., et al. (1999). Bioelectromagnetic localization of a pacing catheter in the heart. Physics in medicine and biology, 44(10), 2565-2578.
Peterson, L. R., Waggoner, A. D., Schechtman, K. B., Meyer, T., Gropler, R. J., Barzilai, B., et al. (2004). Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. Journal of the American College of Cardiology, 43(8), 1399-1404.
Position of the American Dietetic Association and the Canadian Dietetic Association: nutrition for physical fitness and athletic performance for adults. (1993). Journal of the American Dietetic Association, 93(6), 691-696.
Rauramaa, R., Vaisanen, S. B., Rankinen, T., Penttila, I. M., Saarikoski, S., Tuomilehto, J., et al. (1995). Inverse relation of physical activity and apolipoprotein AI to blood pressure in elderly women. Medicine and science in sports and exercise, 27(2), 164-169.
Rosa, E. C., Moyses, V. A., Sesso, R. C., Plavnik, F. L., Ribeiro, F. F., Kohlmann, N. E., et al. (2002). Left ventricular hypertrophy evaluation in obese hypertensive patients: effect of left ventricular mass index criteria. Arquivos brasileiros de cardiologia, 78(4), 341-351.
Shimokata, H., Tobin, J. D., Muller, D. C., Elahi, D., Coon, P. J., & Andres, R. (1989). Studies in the distribution of body fat: I. Effects of age, sex, and obesity. Journal of gerontology, 44(2), M66-73.
Stepien, R. L., Hinchcliff, K. W., Constable, P. D., & Olson, J. (1998). Effect of endurance training on cardiac morphology in Alaskan sled dogs. Journal of Applied Physiology, 85(4), 1368-1375.
Takala, P., Hanninen, H., Montone, J., Makijarvi, M., Nenonen, J., Oikarinen, L., et al. (2001). Magnetocardiographic and electrocardiographic exercise mapping in healthy subjects. Annals of biomedical engineering, 29(6), 501-509.
Takala, P., Hanninen, H., Montonen, J., Korhonen, P., Makijarvi, M., Nenonen, J., et al. (2002). Heart rate adjustment of magnetic field map rotation in detection of myocardial ischemia in exercise magnetocardiography. Basic research in cardiology, 97(1), 88-96.
Tasić, I. S., Lovic, B. K., Hic, S., Djordjević, D., & Tasić, N. M. (2002). Relationship between obesity decrease and regression of hypertensive left ventricular hypertrophy. Facta Universitaties Series: Medicine and Biology, 9 (2), 181-187.
Tavarozzi, I., Comani, S., Del Gratta, C., Romani, G. L., Di Luzio, S., Brisinda, D., et al. (2002). Magnetocardiography: current status and perspectives. Part I: Physical principles and instrumentation. Italian heart journal., 3(2), 75-85.
Thomas, D. P., McCormick, R. J., Zimmerman, S. D., Vadlamudi, R. K., & Gosselin, L. E. (1992). Aging- and training-induced alterations in collagen characteristics of rat left ventricle and papillary muscle. The American journal of physiology, 263(3 Pt 2), H778-783.
Utriainen, T., Nuutila, P., Takala, T., Vicini, P., Ruotsalainen, U., Ronnemaa, T., et al. (1997). Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus. The Journal of clinical investigation, 100(4), 777-785.
Visser, M., Launer, L. J., Deurenberg, P., & Deeg, D. J. (1997). Total and sports activity in older men and women: relation with body fat distribution. American journal of epidemiology, 145(8), 752-761.
Wilmore, J. H. (1983). Body composition in sport and exercise: directions for future research. Medicine and science in sports and exercise, 15(1), 21-31.
Windecker, S., Allemann, Y., Billinger, M., Pohl, T., Hutter, D., Orsucci, T., et al. (2002). Effect of endurance training on coronary artery size and function in healthy men: an invasive followup study. American journal of physiology, 282(6), H2216-2223.
Wing, R. R. (1999). Physical activity in the treatment of the adulthood overweight and obesity: current evidence and research issues. Medicine and science in sports and exercise, 31(11 Suppl), S547-552.