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研究生： 郭昭顯
Guo, Jhao-Sian
論文名稱： 開發硫摻雜石墨烯量子點之電漿子胜肽晶片於人工唾液中檢 測人類角細胞蛋白 19 分子
Development of sulfur-doped graphene quantum dots-peptidebased surface plasmon resonance biosensors in spiked artificial saliva to detect recombinant human cytokeratin 19 his protein (NBP2)
指導教授： 邱南福
Chiu, Nan-Fu
口試委員： 陳震宇
Chen, Cheng-Yu
劉子毓
Liu, Tzu-Yu
董國忠
Dong, Guo-Chung
邱南福
Chiu, Nan-Fu
口試日期： 2023/12/26
學位類別： 碩士
Master
系所名稱： 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年： 2024
畢業學年度： 112
語文別： 中文
論文頁數： 91
中文關鍵詞： 硫摻雜石墨烯量子點 、表面電漿子共振 、生物感測器 、肺癌生物標誌物 NPB2 蛋白
英文關鍵詞： S-GQD, surface plasmon resonance, biosensor, lung cancer biomarker NPB2 protein
研究方法: 實驗設計法
DOI URL： http://doi.org/10.6345/NTNU202400174
論文種類： 學術論文
相關次數： 點閱：95  下載：0 
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    • 致謝 i 摘要 ii Abstract iii 表目錄 viii 圖目錄 ix 第一章 緒論 1 壹、研究動機 1 貳、研究目的 2 第二章 文獻回顧 3 壹、石墨烯概論 3 貳、石墨烯量子點 3 一、石墨烯量子點製備 4 (一)、由上至下 (Top-down) 4 1. 水熱法/溶劑熱 (Hydrothermal /solvothermal method) 5 2. 超聲波法 (Ultrasonic-assisted method) 6 3. 電化學氧化法 (Electrochemical oxidation method) 7 (二)、由下至上 (Bottom-up) 8 1. 熱解法/水熱法 (Pyrolysis method) 8 2. 微波輔助合成法 (Microwave-assisted synthesis method) 9 3. 化學合成法 (Chemical synthesis method) 10 (三)、綠色合成 (Green synthesis) 11 二、原子摻雜GQD 14 (一)、氮摻雜GQD (Nitrogen-GQD) 14 (二)、硼摻雜GQD (Boron-GQD) 15 (三)、硫摻雜 (Sulfur-doping) 16 (四)、共摻雜 (Co-doping) 18 三、 GQD光學特性 18 (一)、吸光度 (Absorbance) 18 (二)、光致發光 (Photoluminescence, PL) 19 四、 GQD之生物應用 22 (一)、GQD之生物相容性 22 (二)、GQD感測器之應用 25 1. PL感測器 25 2. 電化學感測器 28 3. 電致發光感測器 29 參、表面電漿子共振 31 一、SPR簡介 31 二、SPR原理 32 三、SPR的生物應用之分析 34 肆、肺癌檢測及生物標誌物NBP2蛋白介紹 36 一、肺癌簡介 36 二、NBP2簡介 37 三、KRT19 blocking peptide介紹 39 第三章 實驗方法與材料 40 壹、石墨烯量子點及硫摻雜石墨烯量子點的合成 40 一、熱解合成檸檬酸石墨烯量子點 (CA-GQDps) 40 二、熱解合成MPA石墨烯量子點 (MPA -GQDps) 41 三、熱解合成MHA石墨烯量子點 (MHA -GQDps) 42 四、微波輔助合成CA石墨烯量子點 (CA-GQDmas) 43 五、微波輔助合成MPA石墨烯量子點 (MPA-GQDmas) 43 六、微波輔助合成MHA石墨烯量子點 (MHA-GQDmas) 44 貳、感測晶片的製備 45 一、傳統半胱胺酸鹽感測晶片 (Cys-chip) 45 二、硫摻雜石墨烯量子點感測晶片 (MHA-GQD-chip) 46 參、SPR感測肺癌蛋白NBP2之實驗步驟 47 一、傳統緩衝液樣本之檢測 47 二、摻雜人工唾液緩衝液樣本之檢測 48 肆、材料 49 伍、儀器 50 第四章 結果與討論 51 壹、材料分析 51 一、材料結構特性之分析 51 (一)、拉曼光譜之分析 51 1. 拉曼雷射波長的選擇 51 2. 拉曼光譜參數之調整 53 3. 微波輔助合成之拉曼分析 53 (二)、微波合成之傅立葉轉換紅外光譜分析 56 (三)、微波合成之XPS分析 57 (四)、微波合成MHA-GQD之TEM 59 二、GQD光學特性之分析 60 (一)、Uv-vis光譜分析 60 (二)、螢光光譜之分析 61 三、材料穩定性 62 (一)、GQD熱穩定性之分析 62 (二)、GQD懸浮穩定性之分析 62 (三)、GQD的pH定性之分析 63 四、 比較熱解合成法與微波合成法 65 (一)、熱解合成法與微波合成法螢光光譜比較之分析 65 (二)、熱解合成法與微波合成法懸浮穩定性比較之分析 68 貳、生物實驗 69 一、SPR共振角分析與模擬折射率 69 二、MHA-GQDmas150s與peptide結合的螢光光譜 72 三、SPR檢測NBP2之分析 73 (一)、在標準Buffer PBS中比較Cys-chip與MHA-GQD-chip對於NBP2樣本之分析 73 (二)、MHA-GQD-chip對於摻雜人工唾液之NBP2樣本分析 74 第五章 結論與未來展望 76 壹、結論 76 貳、未來展望 77 第六章 參考文獻 78

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