為了模擬藍銅蛋白以及胜肽甘胺酸-羥化氧化酶(Peptidylglycine -hydroxylating monooxygenase，簡稱PHM)的活性中心，我們合成出一個含氮硫之三牙配位基(BMPS)，並成功地合成出一系列具有BMPS二價和一價銅錯合物：[Cu(BMPS)(CH3CN)2](ClO4)2 (1)、[Cu(BMPS)2]- (ClO4)2 (2)、[Cu(BMPS)(CH3CN)](ClO4)2 (3) 和 [Cu(BMPS)2](OTf)2 (4)。將錯合物1與硫醇鈉鹽反應希望合成出模擬氧化態的藍銅蛋白活性中心。於- 40 ºC低溫下將硫醇鈉鹽加入錯合物1，隨著溫度回到室溫溶液由原本深藍色變至棕色沉澱，可知反應所得之二價銅錯合物在室溫下不穩定。因此我們嘗試模擬還原態的藍銅蛋白活性中心，將錯合物4分別與[(CH3)3SiC6H4S]-以及[C6H5C(O)NHC6H5S]-反應，其產物由核磁共振氫譜推測，有[Cu(BMPS)((CH3)3SiC6H4S)]和[Cu (BMPS) (C6H5C(O) NHC6- H5 S)]的生成。將雙核結構的錯合物4與PPh3、CNC(CH3)3、CO等小分子反應可形成一系列單核錯合物：[Cu(BMPS)PPh3](OTf) (5)， [Cu(BMPS)(CNC(CH3)3)](OTf) (6)，而 [Cu(BMPS)(CO)](OTf) 分子的生成由IR光譜鑑定，顯示錯合物4具有良好的反應性。若將氧氣與錯合物4在乙腈下反應，以紫外-可見光光譜偵測該溶液在400 nm附近並無發現任何的電荷轉移峰，故得知沒有形成Cu(II)-superoxo錯合物。

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