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研究生: 吳政育
Wu, Cheng-Yu
論文名稱: 直排輪環島運動對肝功能指數之影響
Effects of In-line Skating Around the Island on the Index of Liver Function
指導教授: 許樹淵
Hsu, Shu-Yuen
學位類別: 碩士
Master
系所名稱: 體育學系
Department of Physical Education
論文出版年: 2009
畢業學年度: 97
語文別: 中文
論文頁數: 53
中文關鍵詞: 肝功能指數麩草酸轉胺酶麩丙酮酸轉胺脢
英文關鍵詞: AST, ALT
論文種類: 學術論文
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  • 本研究的目的在了解直排輪環島運動對肝功能指數之影響。實驗召募8名健康男性(平均年齡:20.29 ± 1.11歲,直排輪溜齡:9.71 ± 1.25年,最大攝氧量:51.93 ± 9.17 ml.min-1.kg-1)為研究對象。所有受試者進行連續七天的直排輪環島運動(全程953公里),並於第一天出發前、第一天結束後、第七天出發前、第七天結束後、環島結束後36小時、結束後10天等6個時間點進行採血,以了解麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)的變化情形及相關性。所得數據,以重複量數單因子變異數及皮爾遜積差相關進行分析。結果發現:(1)環島結束後,AST與ALT都明顯上升,AST直到環島結束後十天才回復至安靜值,而ALT則仍維持明顯增加的現象(p< .05)。(2)AST/ALT比值變化上在環島結束後十天明顯低於正常值範圍(p< .05)。(3)直排輪環島運動前後,AST與ALT彼此間呈顯著正相關(r=0.51;p< .05)。結論:直排輪環島運動多少會對身體機能造成負擔,因此,在運動過程中持續時間、休息時間與營養補給等應加以規劃,以減少對身體產生負面的影響。

    關鍵詞:直排輪環島運動、肝功能指數、麩草酸轉胺酶、麩丙酮酸轉胺酶

    Purpose: The purpose of this study was to examine the effects of In-line skating around the island on the index of liver function. Method: Eight university male students (average age: 20.29 ± 1.11 years, experience of in-line skating: 9.71 ± 1.25 years, maximum oxygen intake: 51.93 ± 9.17 ml.min-1.kg-1) were recruited as the subjects for this study. All subjects finished the in-line skating around the island (total of 953 kilometers). The blood samples were collected at the 1st before exercise around the island (T1), the 1st after exercise around the island (T2), 7th day before exercise around the island (T3), 7th day after exercise around the island (T4), 36 hours after journey (T5), and 10 days after journey (T6). The concentration of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) vere measured. The datas were analyzed by repeated one-way ANOVA and Pearson product moment correlation. Resuts: 1)The concentration of AST was significantly higher at T4 until T5 than T1, and ALT was significantly higher (p< .05) at T4 until T6 than T1. 2) The ratio of AST/ALT was significantly lower at T5 until T6 than T1, and the ratio of AST/ALT at T6 was significantly lower than normal range. 3) The concentration of AST and ALT was singnifcant positive correlation (p< .05). Conclusion: After in-line skating around island, it sharpened the workload in our bodies. It’s important to distribute the time between motion and rest for health care during the in-line skating around insland.

    Keywords: In-line skating around the island, Liver function index, AST, ALT

    中文摘要 Ⅰ 英文摘要 Ⅱ 謝誌 Ⅲ 目次 IV 表次 VI 圖次 VII 第壹章 緒論 1 第一節 問題背景 1 第二節 研究目的 5 第三節 研究假設 5 第四節 名詞操作性定義 5 第貳章 文獻探討 7 第一節 肝臟簡介 7 第二節 運動對肝臟功能之影響 9 第三節 本章總結 18 第參章 研究方法 20 第一節 實驗對象 20 第二節 實驗時間 20 第三節 實驗地點 21 第四節 實驗設計 21 第五節 實驗方法與程序 23 第六節 血液分析 26 第七節 資料分析與處理 28 第肆章 結果與分析 29 第一節 受試者基本資料 29 第二節 環島運動前後麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)的變化情 形 30 第三節 環島運動前後麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)比值的變化情形 32 第四節 單日運動前後麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)改變量的變化情形 34 第五節 單日運動前後麩草酸轉胺酶(AST)改變量、麩丙酮酸轉胺酶(ALT)改變量與運動強度之關係 35 第六節 環島運動過程中麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)之關係 36 第伍章 討論與結論 37 第一節 直排輪環島運動對麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)之影響 37 第二節 單日運動對麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)之影響 41 第三節 結論 43 第四節 建議 44 引用文獻 45 附錄 53 表 次 表3-5-1 Bruce法測驗程序表 24 表3-5-2環島過程中每日完成里程數、平均時速、花費時間一覽表 26 表4-1-1受試者基本資料 30 表4-2-1環島運動前後AST與ALT之變化情形 31 表4-2-2環島運動前後不同時間點AST之變異數分析摘要表 32 表4-2-3環島運動前後不同時間點 ALT之變異數分析摘要表 32 表4-3-1環島運動前後AST與ALT比值之變化情形 33 表4-3-2環島運動前後不同時間點AST/ALT之變異數分析摘要表 33 表4-4-1單日運動前後AST與ALT改變量之變化情形 34 表4-4-2單日運動前後不同時間點AST改變量之變異數分析摘要表 35 表4-4-3單日運動前後不同時間點 ALT改變量之變異數分析摘要表 35 表4-5-1單日運動前後麩草酸轉胺酶(AST)改變量、麩丙酮酸轉胺酶(ALT)改變量與運動強度之相關係數表 36 表4-6-1環島運動過程中麩草酸轉胺酶(AST)與麩丙酮酸轉胺酶(ALT)之相關係數表 36 圖次 圖3-4-1實驗流程圖 22

    一、中文部分
    金井弘一(1999)。肝臟病-沈默的臟器會說話。台北市:益群書局。
    許樹淵、崔凌震(2008)。運動訓練醫學。台北市:師大書苑。
    癌症論談(1999)。認識肝病。轉載自肝病防治特刊,中華民國肝病防治學術基金會。
    林文煌(2003)。十二週快走訓練對健康B 型肝炎帶原者的肝功能影響。國立虎尾技術學院鼓勵性研究計畫成果報告,92 年2 月1 日至93 年1月31日。
    黃奕仁、呉慧君、陳文茹、林孟賢(2004)。24小時超級馬拉松對跑者肝膽功能之影響。大專體育學刊,6(1),275-283。
    黃盈翔,盧豐華(2003)。老年人之用藥原則。台灣醫學,7卷3期。
    黃憲鐘(2005)。密集運動訓練對B型肝炎帶原運動選手肝臟及血液相關指標變化之研究。體育學報,中華民國體育學會,第38卷第3期,頁1~8。
    林淑惠(2008)。直排輪環島運動對血漿飢餓素及瘦體素濃度之影響,師大 書苑,頁2-3。
    徐吉德、任玟樺和徐吉龍。簡述直排輪在運動領域上相關研究之探討,東師體育,12 民94.12 頁83-86。
    莊訓達。休閒活動的新寵--直排輪溜冰運動,崇右學報,6 民86.12 頁310-325。

    二、外文部分
    (一)西文

    Aithal, G. P., Rawlins, M. D., & Day, C. P. (2000). Clinical diagnostic scale: auseful tool in the evaluation of suspected hepatotoxic adverse drugreactions. Journal of Hepatology, 33 (6), 949-952.

    Lin, C. L., Chen. M. F., Chung, M. C., Lin, M. H.(2004). The Effect of sub-maximalexercise upon students suffering chronic hepatitis B infection. Journal of Internal Medicine Taiwan, 15: 208-213.

    Clarkson, P. M., Kearns, A. K., Rouzier, P., Rubin, R., & Thompson, P. D. (2006). Serum creatine kinase and renal function measures in exertional muscle damage. Medicine & Science in Sports & Exercise, 38, 623–627.

    Dajani, L. K., Paus, E., & Warren, D. J. (2001). Development of a rapid and sensitive immunofluorometric assay for gluthatione S-transferase A. Clinical Chemistry, 47, 867–873.

    Dempsey, J. A., Hanson, P. G., Henderson, K. S. (1984). Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. Journal of Physiology, 355, 161-175.

    De paz, J. A., Villa, J. G., Lopez, P., & Gonzalez-Gallego, J. (1995). Effect of long-distance running on serum bilirubin. Medicine & Science in Sports & Exercise, 27(12), 1590-1594.

    Dufour, D. R., Lott, J. A., Nolte, F. S., Gretch, D. R., Koff, R. S., & Seeff, L. B. (2000a). Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests. Clinical Chemistry, 46(12), 2027-2049.

    Dufour, D. R., Lott, J. A., Nolte, F. S., Gretch, D. R., Koff, R. S., & Seeff, L. B. (2000b). Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring. Clinical Chemistry, 46(12), 2050-2068.

    Ekblom, B., & Hermansen, L. (1968). Cardiac output in athletes. Journal of Applied Physiology, 25, 619-625.

    Farber, H., Arbetter, J., Schaefer, E., Hill, S., Dallal, G., Grinaldi, R., & Hill, N. (1987). Acute metabolic effect of an endurance triathlon. Annals of Sports Medicine, 3(2), 131-138.

    Fallon, K. E., Sivyer, G., Sivyer, K., & Dare, A. (1999). The biochemistry of runners in a 1600 km ultramarathon. British Journal of Sports Medicine, 33, 264-269.

    Fortson, W. C., Tedesco, F. J., Starnes, E. C., & Shaw, C. T. (1985). Marked Elevation of serum transaminase activity associated with extrahepatic Biliary tract disease. Journal of Clinical Gastroenterology, 7(6), 502-505.

    Fu, F. H., You, C. Y., Kong, Z. W. (2002). Acute changes in selected serum enzyme and metabolite concentrations in 12- to 14-yr.-old athletes after an all-out 100-m swimming sprint. Perceptual and Motor Skills, 95(3 Pt 2), 1171-8.

    Holly, R. G., Barnard, R. J., Rosenthal, M., Applegate, E., & Pritikin, N. (1968). Triathlete characterization and response to prolonged strenuous competition. Medicine & Science in Sports & Exercise, 18(1), 123-127.

    Hyo, J. K., Yoon, H. L., & Chang, K. K. (2007). Biomarkers of muscle and cartilage damage and inflammation during a 200 km run. European Journal of Applied Physiology, 99, 443–447.

    Katsuhiko, S., Jonathan, P., Kazunori, N., Mitsuharu, O., Chris, R. A., Rob, S., David, B., Marc, J. Q., Hamilton, L., David, T. M., & Paul, B. L. (2006). Changes in markers of muscle damage, inflammation and HSP70 after an Ironman triathlon race. European Journal of Applied Physiology, 98, 525–534

    Koutedakis, Y., Raafat, A., Sharp, N. C., Rosmarin, M. N., Beard, M.J., & Robbins, S. W. (1993). Serum enzyme activities in individuals with different levels of physical fitness. Journal of Sports Medicine and Physical Fitness, 33(3), 252-257.

    Knapen, M., Mulder, T., Bisseling, J., Penders, R., Peters, W., & Steegers, E. (1998). Plasma gluthatione S-transferase alpha 1-1: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy. American Journal of Obstetrics & Gynecology, 178, 161–165.

    Kuipers, H., (1994). Exercise-induced muscle damage. International Journal of Sports Medicine, 15, 132-135.

    Lee, W. (2003). Drug-induced hepatotoxicity. New England journal of medicine, 349, 474-478.

    Lindena, J., & Trautschold. (1983). Enzymes in lymph: A review . J. Clin. Chem. Clinical Biochemistry, 21, 327-346.

    Lohman, K., & Meyerhof, O. (1934) Über die enzymatische umwandlung von phosphoglyzerinsäure in brenztraubensäure und phosphorsäure (Enzymatic transformation of phosphoglyceric acid into pyruvic and phosphoric acid). Biochemische Zeitschrift, 273, 60–72.

    Marcos, B. M., Monica, B., & Fernanda, C. R. B. (2008). Liver overload in Brazilian riathletes after half-ironman competition is related muscle fatigue. Annals of Hepatology, 7(3), 245-248.

    Margaritis, I., Tessier, F., Verdera, F., Bermon, S., & Marconnet, P. (1999). Muscle enzyme release does not predict muscle function impairment after triathlon. Journal of sports medicine and physical fitness, 39(2), 133-139.

    Melanson, E. L., Freedson, P. S., Jungbluth, S. (1996). Changes in VO2max and maximal treadmill time after 9 wk of running or in-line skate training. Medicine & Science in Sports & Exercise, 28(11), 1422-1426.

    Mena, P., Maynar, M., & Campillo, J. E. (1996). Change in plasma enzyme activities in professional racing cyclists. British Journal of Sports Medicine, 30(2), 122-124.

    Nagel, D., Seiler, D., Franz, H., & Jung, K. (1990). Ultra-long-distance running and the liver. International Journal of Sports Medicine, 11(6), 441-445.

    Noakes, T. D. (1987). Effect of exercise on serum enzyme activities in humans. Sports Medicine, 4, 245-267.

    Nosaka, K., & Clarkson, P. M. (1996). Changes in indicators of inflammation after accentric exercise of the elbow flexors. Medicine & Science in Sports & Exercise, 28(8), 953-961.

    Pettersson J, Hindorf U, Persson P, Bengtsson T, Malmqvist U, Werkström V, & Ekelund M (2007). Muscular exercise can cause highly pathological liver function tests in healthy men. British journal of clinical pharmacology, 65(2), 253–259.

    Perlmutter, G. S., Bies, C., Fagan, T., & Lowenthal, D. T. (1987). The kinetics of serum enzymes following maximal exercise stress testing in healthy men. Annals of Sports Medicine, 3(3), 178-181.

    Rehrer, N. J., Brouns, F., Beckers, E. J., Frey, W. O., VilUger, B., & Riddoch, C. J., et al. (1992). Physiological changes and gastro-intestinal symptoms as a result of ultra-endurance running. European journal of applied physiology, 64, 1-8.

    Rej, R.(1989). Aminotransferases in disease. Clinics in laboratory medicine, 9(4), 667-687.

    Rogers, M. A., Stull, G. A., & Apple, F. S. (1985). Creatine kinase isoenzyme activities in men and women following a marathon race. Medicine & Science in Sports & Exercise, 17, 679-682.

    Saengsirisuwan, V., Phadungkij, S., & Pholpramool, C. (1998). Renal and liver functions and muscle injuries during training and after competition in Thai boxers. British Journal of Sports Medicine, 32, 304-308.

    Schwane JA, Johnson SR, Vandenakker CB, & Armstrong RB (1983). Delayed-onset muscular soreness and plasma CPK and LDH activities after downhill running. Medicine & Science in Sports & Exercise, 15, 51-56.

    Sellers, E. M., & Freedman, F. (1981). Treatment of acetaminophen poisoning. Canadian Medical Association journal, 125(8), 827-829.

    Skenderi, K. P., Kavouras, S. T. A., Anastasiou, C. A., Yiannakouris, N., & Matalas, A. L. (2006). Exertional rhabdomyolysis during a 246-km continuous running race. Medicine & Science in Sports & Exercise, 38, 1054-1057.

    Smith, J. E., Garbutt, G., Lopes, P., & Pedoe, D. T. (2004). Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. British journal of sports medicine, 38, 292-294.

    Snyder, A. C., O'Hagan, K. P., Clifford, P. S., Hoffman, M. D., & Foster, C. (1993). Exercise responses to in-line skating: comparisons to running and cycling. International journal of sports medicine, 14(1), 38-42.

    Soeder, G., Golf, S. W., Graef, V., Temme, H., Brustle, A., & Roka, L., et al (1989). Enzyme catalytic concentrations in human plasma after a marathon. Clinical Biochemistry, 22(2), 155-159.

    Spitler, D. L., Alexander, W. C., Hoffler, G. W., Doerr, D. F., & Buchanan, P. (1984). Haptoglobin and serum enzymatic response to maximal exercise in relation to physical fitness. Medicine & Science in Sports & Exercise, 16(4), 366-370.

    Vanderlinde, R. E. (1986). Review of pyridoxal phosphate and the transaminases in liver disease. Annals of clinical laboratory science, 16(2), 79-93.

    Wroblewski, F. (1958). The clinical significance of alterations in transaminase activities of serum and other body fluids. Advances in clinical chemistry, 1(2), 313-351.
    (二)日文
    井川幸雄(1980)。運動負荷が血液検査と肝臓の組織学的変化に及ぼす影響。臨床病理。28(1),39-44。

    木下幸文,矢野里佐,矢野博已(1996)。異なる運動強度における血清グアナーゼ活性変動。体力科学,45,527-530。

    賀来正俊(1994)。マラソン・長距離選手における非外傷性筋肉障害と肝臓機能の鑑別判断。臨床スポーツ医学,11(6),695-701。

    遠藤章二,小笠原由美子,宮崎廣子,沖本鶴美(1995)。健康と食生活に関する調査研究:(第九報)地方公務員の身体状況の検討(平成7年度)。聖カタリナ女子短期大学紀要,30,93-129。

    田村善蔵,織田敏次(1970)。血清酵素一測定法・意義・臨床一,第1版,III.酵素の血清毛の漏出機構。医学書院,東京,21-39。
    江橋慎四郎 (1959)。レクリエーション指導者の養成--アメリカの場合--特集・レクリェーション。体育の科学,杏林書院,9(5),pp.201〜203,206。

    本鄉立憲,廣重 力(2000)。標準生理學,第5版,第9章,III,血液循環‧C‧リンパ循環。医学書院,東京,555-561。

    鈴木政登(2002)。運動と血清酵素。体力科学,51,407-422。

    鈴木政登、飯島好子、塩田正俊,松原 茂,井川幸雄,町田勝彥(1990)、ジョギング愛好者のフルマラソン後の血液・尿成分の変化。臨床スポーツ化学,7(7),813-820。

    井川幸雄(1984)。運動と酵素。臨床栄養,65,518-552。

    黒田善雄,井川幸雄,高澤晴夫,中島寛之,村川正博(1990)。第二章3消化器,最新スポーツ医学,初版。文光堂,東京,pp144。

    西川洋子(1986)。Guanaseの酵素化学ならびに臨床応用に関する研究,文部省化学研究による研究報告集。医学および薬学編,pp1-2。

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