前言：阻力訓練對於骨骼肌肌力發展基因表現的提升具有正面的效果，如果訓練同時增補具有活化肌力發展基因調控之增補物，可能提升負重運動表現。北冬蟲夏草 (Cordyceps militaris，以下簡稱蟲草) 中之蟲草素 (cordycepin) 可能誘發老鼠骨骼肌脂肪代謝基因表現，而對於肌力表現的調節因子如IGF-1Ea、MGF和myostatin (MSTN) 則尚無研究發表，如以動物模式輔以負重訓練，是否能如預期誘發肌力基因表現，需要進一步證實。目的：探討負重階梯攀爬訓練對攝食北冬蟲夏草大鼠骨骼肌肌力發展基因表現之影響。方法：將32隻7週齡SD大鼠分成4組：1.控制組 (C, n=8)：無處理。2.蟲草組 (CM, n=8)：灌食劑量200 mg/kg/d北冬蟲夏草粉劑。3.訓練組 (T, n=8)：負重訓練。4.蟲草訓練組 (TCM, n=8)：灌食劑量200 mg/kg/d北冬蟲夏草粉劑外加負重訓練。訓練組實施3次/週，共6週之負重階梯攀爬訓練，3週時各組犧牲4隻 (中測)，6週結束前各組實施負重測試後犧牲 (後測)。取腓腸肌 (快縮肌) 和比目魚肌 (慢縮肌) 實施半定量反轉錄-聚合酶鏈鎖反應 (semi-quantitative SqRT-PCR) 分析肌力發展調控基因之表現。統計以二因子變異數分析以及杜凱氏事後比較，顯著水準為p＜.05。結果：6週蟲草攝食和負重訓練對於體重和負重運動表現無顯著影響，但上調腓腸肌IGF-1Ea (後測) 和MGF (中測和後測) 基因，同時下調MSTN (中測和後測) 基因，且TCM在MSTN基因的下調具有協同效應 (synergistic effect)；對比目魚肌IGF-1Ea和MGF的調控影響不大，只有TCM下調MSTN (後測) 基因。結論：蟲草攝食和負重訓練對大鼠快縮肌群IGF-1Ea 和MGF基因具有正向調控效果，但對慢縮肌群的表現影響較小；無論在快縮或慢縮肌，蟲草攝食和負重訓練對MSTN基因的下調表現皆有顯著影響。

Introduction：Recent studies have confirmed that resistance training can regulate the gene expression of muscle strength growth factors (MSGF). It has been demonstrated that Cordycepin of Cordyceps militaris (CM) can induce the fatty-acid metabolism gene in rat muscles , such as AMPK, PGC-1α and PPAR-δ. However, the effects on genes involved in muscle strength, such as the genes coding for IGF-1Ea、MGF and myostatin (MSTN) have not been examined. The effects of resistance training with CM supplementation to enhance muscle strength factor needs further investigation. Purpose: To investigate the effects of resistance training on MSGF gene expression in CM supplemented rats. Methods: Thirty-two 7-wk-old Sprague-Dawley rats were divided into 4 groups: 1.Control group (C, n=8): general feeding. 2. CM feeding group (CM, n=8): general feeding mixed with 200mg/kg/d CM extract. 3. Training group (T, n=8): loaded resistance training on climbing ladder. 4. Training with CM feeding group (TCM, n=8): general feeding mixed with 200mg/kg/d CM extract, and loaded resistance training on climbing ladder. A progressive exercise training protocol was adopted 3 days/week on T and TCM for 6 weeks. Four rats from each group were sacrificed after 3 weeks of experimentation as middle-testing. The others were sacrificed after the loading-test at the end of the experiment as final-testing. Semi-quantative RT-PCR was used to analyse the expression of muscle strength genes on gastrocnemius (fast twitch muscle) and soleus (slow twitch muscle). A 2-way ANOVA and Tukey’s test was used to compare the differences among the groups. Significant level was set at p <.05. Results: CM supplementation and resistance training for 6 weeks had no significantly effects on the body weight and the loading-test results. However, IGF-1Ea was up-regulated in gastrocnemius in the final-test, and MGF was up-regulated in both middle- and final-tests. MSTN was down-regulated in gastrocnemius in both middle- and final-tests. Resistance training and CM supplementation had synergistic effect on down-regulating the MSTN. In soleus, no significant effect on regulation of IGF-1Ea and MGF was observed, but down-regulation of MSTN was detected in TCM. Conclusions：CM supplementation and resistance training had positive effects on IGF-1Ea and MGF expressions, and negative effects on MSTN expressions of fast twitch muscles in rats, as well as minor effects on slow twitch muscles.

王四切 (2005)。北冬蟲夏草對細胞之造精作用與抗氧化功能評估之研究─子計畫一:北冬蟲夏草對小鼠睪丸之萊氏細胞 TM3 中睪固酮生合成之影響。嘉南藥理科技大學專題研究計畫成果報告（頁2-6）。台南市：嘉南藥理科技大學。
王靖雅 (2010)。北冬蟲夏草對老化促進小鼠抗氧化狀態及學習記憶之探討 (未出版碩士論文)。靜宜大學，台中市。
王靜、蘇有存、盧健 (2011)。負重爬梯訓練對大鼠腓腸肌IGF-1、IGF-1Ea、MGF 和MSTN基因表達的影響。山東體育學院學報，27(5)，55-58。
江俊逸 (2002)。補充冬蟲夏草對能量利用及運動表現之影響 (未出版碩士論文)。國立體育學院，桃園市。
宋文君 (2008)。人工培養北蟲草子實體對mitomycin C所誘導的毒性之化學預防性評估 (未出版碩士論文)。嘉南藥理科技大學，台南市。
李立仁 (1997)。冬蟲夏草菌萃取液對大白鼠腎上腺皮質細胞皮質酮分泌功能及脂肪滴型態的影響 (未出版碩士論文)。國立臺灣大學，台北市。
吳明隆 (2011)。 SPSS統計應用學習實務問卷分析與應用統計。新北市：易習圖書。
吳銘芳、呂旭峰、吳龍源、葉明陽、敖曼冠 (2011)。以跑步試驗評估冬蟲夏草菌絲體抗疲勞功能。傳統醫學雜誌，22(1)，35-43。
林嘉志、沙布‧魯比、李嘉宜、徐國峰、陸康豪、張嘉珍、…蘇玫尹 (譯)(2014)。ACSM基礎肌力與體能訓練。臺北市：藝軒。(Ratamess, N., 2012)。
姚紅、黃少華、蘇子仁、溫娜 (2005)。葛根蟲草軟膠囊對大鼠實驗性骨質疏鬆之影響。廣東藥學院學報，21(5)，553-559。
陳永佳 (2002)。冬蟲夏草刺激萊氏腫瘤細胞固醇類生成機制之探討 (未出版碩士論文)。國立成功大學，台南市。
黃鈺玲 (2008)。冬蟲夏草於糖尿病大鼠模式肌肉中降血糖機制之探討 (未出版碩士論文)。東海大學，台中市。
黃懷玉 (2001)。補充冬蟲夏草配合重量訓練對於身體組成、血液生化值及最大總肌力之影響 (未出版碩士論文)。國立體育學院，桃園縣。
黃懷玉、許美智 (2000)。冬蟲夏草對於運動表現之影響。大專體育，48，133-136。
莊曉莉、李祥麟、黃檀溪 (2003)。蠶蛹蟲草具有顯著之抗氧化性與自由基清除能力。師大學報，48 (1，2)，13-24。
張家俊、陳文為 (1992)。天然冬蟲夏草及其培養菌絲體對能量代謝的影響。北京中醫學院學報，15(3)，63-65。
張權發 (1997)。冬蟲夏草對Adriamycin引起腎絲球傷害之影響 (未出版碩士論文)。國立交通大學，新竹市。
蔡九英、翟桂藍、高薇、王慶茹、任旭榮、孫寧 (2004)。黃芩和冬蟲夏草聯合運用對血脂的影響。中國臨床醫生，32(1)，37-38。
劉春英 (1999)。服用冬蟲夏草後血液中黃體生成激素、皮質醇、睪固酮及尿液中睪固酮及表睪固酮數值之變化 (未出版碩士論文)。國立體育學院，桃園縣。
劉春英、許美智 (1999)。運動員禁藥睪酮之生理作用及尿液中檢驗法之探討。大專體育，42，83-90。
簡瑞涓 (2010)。北冬蟲夏草對高葡萄糖誘發人類臍帶內皮細胞氧化損傷之影響 (未出版碩士論文)。嘉南藥理科技大學，台南縣。
謝錦城 (1998)。衰竭運動與肌纖維類型對過氧化物歧化酶的影響。台北：行政院國家科學委員會科學技術資料中心。
Adams, G. R., & Haddad, F. (1996). The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy. Journal of Applied Physiology, 81, 2509-2516.
Adams, G. R., & McCue, S. A. (1998). Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. Journal of Applied Physiology, 84, 1716-1722.
Ahtiainen, J. P., Pakarinen, A., Alen, M., Kraemer, W. J., & Häkkinen, K.(2005). Short vs. long rest period between the sets in hypertrophic resistance training: Influence on muscle strength, size, and hormonal adaptations in trained men. Journal of Strength & Conditioning Research, 19(3), 572-582.
Almeida-Silveira, M. I., Perot, C., Pousson, M., & Goubel, F. (1994). Effects of stretch-shortening cycle training on mechanical properties and fiber type transition in the rat soleus muscle. Pflügers Archiv European Journal of Physiology, 427, 289-294.
Ashton, W. S., Degnan, B. M., Daniel, A., & Francis, G. L. (1995). Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein. Annals of Clinical & Laboratory Science, 25(5), 381-388.
Baldwin, K. M., & Haddad, F. (2002). Skeletal muscle plasticity: cellular and molecular responses to altered physical activity paradigms. American Journal of Physical Medicine & Rehabilitation ,81, S40-S51.
Bamman, M. M., Shipp, J. R., Jiang, J., Gower, B. A., Hunter, G. R., Goodman, A., ... Urban, R. J. (2001). Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans. American Journal of Physiology, Endocrinology and Metabolism , 280, E383–E390.
Barton-Davis, E., Shoturma, D. I., Musaro, A., Rosenthal, N., & Sweeney, H. L. (1998). Viral mediated expression of insulin-like growth factor-I blocks the aging-related loss of skeletal muscle function. Proceedings of the National Academy of Sciences of the United States of America, 95, 15603-15607.
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J., … & Casaburi, R. (1996). The effects of supraphysiological doses of testosterone on muscle size and strength in normal men. New England Journal of Medicine, 335, 1-7.
Bhasin, S., Storer, T. W., Berman, N., Clevenger, B., Yarasheski, K., Phillips, J., … & Casaburi, R. (1997). Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 82, 407-413.
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Bhasin, D., Berman, N., … & Bross, R. (2001). Testosterone dose-response relationships in healthy young men. American Journal of Physiology Endocrinology and Metabolism, 281, E1172-E1181.
Bok, J. W., Lermer, L., Chilton, J., Klingeman, H. G., & Towers, G. H. (1999). Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry, 51(7), 891-898.
Booth, F.W., & Thomason, D.B. (1991). Molecular and cellular adaptation of muscle in response to exercise: Perspectives of various models. Physiological Reviews, 71, 541-585.
Braga, M., Bhasin, S., Jasuja, R., Pervin, S., & Singh, R. (2012). Testosterone inhibits transforming growth factor-beta signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Molecular and Cellular Endocrinology, 350, 39-52.
Caiozzo, V. J., Hadia, F., Baker, M. J., & Baldwin, K. M. (1996). Influence of mechanical loading on myosin heavy-chain protein and mRNA isoform expression. Journal of Applied Physiology, 80, 1503-1512.
Caiozzo, V. J., Ma, E., McCue, S. A., Smith, E., Herrick, R. E., & Baldwin, K. M. (1992). A new animal model for modulating myosin isoform expression by altered mechanical activity. Journal of Applied Physiology, 73, 1432-1440.
Carpenter, J., & Bithell, J. (2000). Bootstrap confidence intervals: When, which, what? A practical guide for medical statisticians. Statistics in Medicine, 19(9), 1141-1164.
Casaburi,R., Bhasin, S., Cosentino, L., Porszasz, J., Somfay, A., Lewis, M. I., … & Storer, T. W. (2004). Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 170, 870-878.
Cheng, Q. (1992). Effect of Cordyceps sinensis on cellular immunity in rats with chronic renal insufficiency. Zhonghua Yi Xue Za Zhi, 72(1), 27-29.
Chen, Y. C., Huang, Y. L., & Huang, B.M. (2005). Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumor cells. International Journal of Biochemistry and Cell Biology, 7(1), 214-223.
Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C.B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. Journal of Alternate and Complimentary Medicine, 16, 585-590.
Chiu, J. H., Ju, C. H., Wu, L. H., Lui, W. Y., Wu, C. W., Shiao, M. S., & Hong, C. Y. (1998). Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens on human hepatoma cell line HA22T/VGH cells. American Journal of Chinese Medicine, 26(2), 159-170.
Chiou, W. F., Chang, P. C., Chou, C. J., & Chen, C. F. (2000). Protein constituent contributes to the hypotensive and vasorelaxant acttvtties of cordyceps sinensis. Life Sciences, 66(14), 1369-1376.
Coleman, M. E., DeMayo, F., Yin, K. C., Lee, H. M., Geske, R., Montgomery, C., & Schwartz, R. J. (1995). Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. Journal of Biological Chemistry, 270, 12109-12116.
Colson, S.N., Wyatt, F.B., Johnston, D.L., Autrey, L.D., FitzGerald, Y.L., & Earnest, C.P. (2005). Cordyceps sinensis and Rhodiola rosea-based supplementation in male cyclists and its effects on muscle tissue oxygen saturation. Journal of Strength and Conditioning Research, 19, 358-363.
Craig, B.W., Brown, R., & Everhart, J. (1989). Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mechanisms of Ageing and Development, 49(2), 159-169.
Dai, G., Bao, T., Xu, C., Cooper, R., & Zhu, J. S. (2001). CordyMax Cs-4 improves steadystate bioenergy status in mouse liver. Journal of Alternative and Complementary Medicine, 7(3), 231-240.
Desvergne, B., & Wahli, W. (1999). Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocrine Reviews, 20(5), 649-688.
DeVol, D. L., Rotwein, P., Sadow, J. L., Novakofski, J., & Bechtel, P. J. (1990). Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. American Journal of Physiology, Endocrinology and Metabolism, 259, E89–E95.
Duncan, N. D., Williams, D. A., & Lynch, G. S. (1998). Adaptations in rat skeletal muscle following long-term resistance exercise. European Journal of Applied Physiology and Occupational Physiology, 77, 372-378.
Earnest, C. P., Morss, G. M., Wyatt, F., Jordan, A. N., Colson, S., Church, T. S., … & Lucla, A. (2004). Effect of a commercial herbal-based formula on exercise performance in cyclists. Medicine & Science in Sports & Exercise, 36(3), 504-509.
Elkasrawy, M. N., & Hamrick, M. W. (2010). Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 56-63.
Escher, P., & Wahli, W. (2000). Peroxisome proliferator-activated receptors: Insight into multiple cellular functions. Mutation Research, 448(2), 121-138.
Exner, G., Staudte, H., & Pette, D. (1973). Isometric training of rats-effect upon fast and slow muscle and modification by an anabolic hormone (Nandrolone Decanoate). Pflügers Archiv European Journal of Physiology, 345, 15-22.
Faraway, J. J. (2006). Extending the linear model with R: Generalized linear, mixed effects and nonparametric regression models. Boca Raton, FL: CRC.
Fitts, R. H. (2003). Effects of regular exercise training on skeletal muscle contractile function. American Journal of Physical Medicine & Rehabilitation, 82, 320-331.
Fluck, M., & Hoppeler, H. (2003). Molecular basis of skeletal muscle plasticity-from gene to form and function. Reviews of Physiology, Biochemistry & Pharmacology,146,159-216.
Fluckey, J. D., Vary, T. C., Jefferson, L. S., & Farrell, P. A. (1996). Augmented insulin action on rates of protein synthesis after resistance exercise in rats. American Journal of Physiology Endocrinology and Metabolism, 270, E313-E319.
Francis, G. A., Annicotte, J. S., & Auwerx, J. (2003). PPAR-α effects on the heart and other vascular tissues. American Journal of Physiology-Heart and Circulatory Physiology, 285(1), H1-H9.
Galvao, D. A., & Taaffe, D. R. (2004). Single vs. multiple-set resistance training: recent developments in the controversy. Journal of Strength & Conditioning Research, 18, 660-667.
Gardiner, P. F., Hibl, B., Simpson, D.R., Roy, R., & Edgerton, V. R. (1980). Effects of a mild weight-lifting program on the progress of glucocorticoid-induced atrophy in rat hindlimb muscles. Pflügers Archiv European Journal of Physiology, 385, 147-153.
Girgenrath, S., & Song, K. (2005). Whittemore LA Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscle. Muscle & Nerve , 31(1), 34-40.
Goldspink, G. (2003). Gene expression in muscle in response to exercise. Journal of Muscle Research and Cell Motility, 24, 121-126.
Goldspink, G. (2005). Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology, 20, 232-238.
Goldspink, G., Scutt, A., Loughna, P., Wells, D., Jaenicke, T., & Gerlach, G. F. (1992). Gene expression in skeletal muscle in response to mechanical signs. American Journal of Physiology- Regulatory, Integrative and Comparative Physiology , 262, R326-R363.
Goldspink, G., & Yang, S. Y. (2001). Method of treating muscular disorders. Retrieved from United States Patent, Patent No. US 6,221,842 B1 Web site: http://www.google.com.tw/patents?hl=zh-TW&lr=&vid=USPAT6221842&id=rzkGAAAAEBAJ&oi=fnd&dq=Method+of+treating+muscular+disorders&printsec=abstract#v=onepage&q=Method%20of%20treating%20muscular%20disorders&f=false
Guo, P., Kai, Q., Gao, J., Lian, Z.Q., Wu, C.M., Wu, C.A., & Zhu, H.B. (2010). Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP activated protein kinase. Journal of Pharmacological Sciences, 113, 395-403.
Haddad, F., & Adams, G. R. (2002). Selected contribution: Acute cellular and molecular responses to resistance exercise. Journal of Applied Physiology, 93, 394-403.
Haddad, F., & Adams, G. R. (2006). Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. Journal of Applied Physiology, 100, 1188-1203.
Hameed, M., Lange, K. H., Andersen, J. L., Schjerling, P., Kjaer, M., Harridge, S. D., & Goldspink, G. (2004). The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men. Journal of Physiology, 555, 231-240.
Hameed, M., Orrell, R. W., Cobbold, M., Goldspink, G., & Harridge, S. D. R. (2003). Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. Journal of Physiology, 547, 247-254.
Hanssen, K. E., Kvamme, N. H., Nilsen, T. S., Rønnestad, B., Ambjørnsen IK, Norheim, F., ... Raastad, T. (2013). The effect of strength training volume on satellite cells, myogenic regulatory factors, and growth factors. Scandinavian Journal of Medicine & Science in Sports, 23(6), 728-739.
Hardie, D.G., & Sakamoto, K. (2006). AMPK: A key sensor of fuel and energy status in skeletal muscle. Physiology, 21, 48-60.
Heinemeier, K. M., Olesen, J. L., Schjerling, P., Haddad, F., Langberg, H., Baldwin, K. M., & Kjaer, M. (2007). Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: Differential effects of specific contraction types. Journal of Applied Physiology, 102(2), 573-581.
Herda, T. J., Ryan, E. D., Stout, J. R., & Cramer, J. T. (2008). Effects of a supplement designed to increase ATP levels on muscle strength, power output, and endurance. Journal of the International Society of Sports Nutrition, 5(1), 1-5.
Hill, M., & Goldspink, G. (2003). Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. Journal of Physiology, 549, 409-418.
Hiyoshi, T., Akasu, F., Yoshisugu, M., & Fujiwara, M. (1996). Supplemental effects of Cordyceps sinensis extract on long distance runners. Japanese Journal of Physical Fitness and Sports Medicine, 45, 205-210.
Hobbs, C. J., Plymate, S. R., Rosen, C. J., & Adler, R. A. (1993). Testosterone administration increases insulin-like growth factor-I levels in normal men. Journal of Clinical Endocrinology & Metabolism, 77(3), 776-779.
Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., & Huang, B. M. (2003). In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sciences, 73(16), 2127-2136.
Hsu, C.C., Lin, Y.A., Su, B., Li, J.H., Huang, H.Y., & Hsu, M.C. (2011). No effect of cordyceps sinensis supplementation on testosterone level and muscle strength in healthy young adults for resistance training. Biology of Sport, 28(2), 107-110.
Hsu, C. C., Tsai, S. J., Huang, Y. L., & Huang, B. M. (2003). Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS Letters, 543(1-3), 140-143 .
Hsu, T.H., Shiao, L.H., Hsieh, C., & Chang, D.M. (2002). A comparison of the chemical composition and bioactive ingredients of the Chinese medical mushroom DongChongXiaCao, its counterfeit and mimic, and fermented mycelium of Cordyceps sinensis. Food Chemistry, 78, 463-469.
Huang, B. M., Hsiao, K. Y., Chuang, P. C., Wu, M. H., Pan, H. A., & Tsai, S. J. (2004). Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biology of Reproduction, 70(5), 1358-1364.
Huang, Y. L., Leu, S. F., Liu, B. C., Sheu, C. C., & Huang, B. M. (2004). In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. Life Sciences, 75(9), 1051-1062.
Hughes, D. C., Stewart, C. E., Sculthorpe, N., Dugdale, H. F., Yousefian, F., Lewis, M. P., & Sharples, A. (2016). Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: Deciphering the role of androgen and IGF-I receptors. Biogerontology, 17(3), 619-639.
Husain, K. (2003). Interaction of physical training and chronic nitroglycerin treatment on blood pressure, nitric oxide, and oxidants/antioxidants in the rat heart. Pharmacology Research,48, 253-261.
Jones, S. W., Hill, R. J., Krasney, P. A., O'Conner, B., Peirce, N., & Greenhaff, P. L. (2004). Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass. FASEB Journal, 18, 1025-1027.
Kim, J. S., Cross, J. M., & Bamman, M. M. (2005). Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. America Journal of Physiology Endocrinology and Metabolism, 288, E1110-E1119.
Klitgaard, H. (1998). A model for quantitative strength training of hindlimb muscle of the rat. Journal of Applied Physiology, 64, 1740-1745.
Klitgaard, H., Marc, R., Brunet, A., Vandewalle, H., & Monod, H. (1989). Contractile properties of old rat muscles: Effects of increased use. Journal of Applied Physiology, 67, 1401-1408.
Koh, J.H., Kim, K.M., Kim, J.M., Song, J.C., & Suh, H.J. (2003). Anti-fatigue and anti-stress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biological and Pharmaceutical Bulletin, 26, 691-694.
Kraemer, W. J., Häkkinen, K., Newton, R. U., Nindl, B. C., Volek, J. S., McCormick, M., … Evans., W. J. (1999). Effects of heavy-resistance training on hormonal response patterns in younger vs. older men. Journal of Applied Physiology, 87, 982-992.
Kumar, R., Negi, P. S., Singh, B., Ilavazhagan, G., Bhargavaa, K., & Sethy, N. K. (2011). Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. Journal of Ethnopharmacology, 136(1), 260-266.
Kuo, Y. C., Lin, C. Y., Tsai, W. J., Wu, C. L., Chen, C. F., & Shiao, M. S. (1994). Growth inhibitors against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides. Cancer investigation, 12(6), 611-615.
Lee, S. J. (2004). Regulation of muscle mass by myostatin. Annual Review of Cell and Developmental Biology, 20, 61-86.
Li, Y., Chen, G. Z., & Jiang, D. Z. (1993). Effect of Cordyceps sinensis on eryopoiesis in mouse bone marrow. Chinese Medical Journal, 106(4), 313-316.
Li, T., Li, W. (2009). Impact of polysaccharides from Cordyceps on anti-fatigue in mice. Scientific Research and Essay, 4, 705-709.
Li, S.P., Yang, F.Q., & Tsim, K.W.K. (2006). Quality control of Cordyceps sinensis, a valued traditional Chinese medicine. Journal of Pharmaceutical and Biomedical Analysis, 41, 1571-1584.
Lin, J., Wu, H., Tarr, P.T., Zhang, C.Y., Wu, Z., Boss, O., … & Spiegelman, B.M. (2002). Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature, 418, 797-801.
Liu, P., Zhu, J., Huang, Y., & Liu, C. (1996). Influence of Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL-1, IFN and TNF produced by rat Kupffer cells. China Journal of Chinese Materia Medica, 21(6), 367-369.
Manabe, N., Azuma, Y., Sugimoto, M., Uchio, K., Miyamoto, M., Taketomo, N., … & Miyamoto, H. (2000). Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism and blood flow in dietary hypoferric anaemic mice. British Journal of Nutrition, 83, 197-204.
Matsakas, A., Friedel, A., Hertrampf, T., & Diel, P. (2005). Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Acta Physiologica Scandinavica ,183, 299-307.
Matsakas, A.,& Diel, P. (2005). The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis. International Journal of Sports Medicine, 26, 83-89.
Matsakas, A., Friedel, A., Hertrampf, T., & Diel, P. (2005). Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Acta Physiologica Scandinavica, 183, 299-307.
Mccall, G. E., Byrnes, W. C., Fleck, S. J., Dickinson, A., & Kraemer, W. J. (1999). Acute and chronic hormonal responses to resistance training designed to promote muscle hypertrophy. Canadian Journal of Applied Physiology, 24(1), 96-107.
McPherron, A. C., Lawler, A. M., & Lee, S. J. (1997). Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature, 387, 83-90.
McPherron, A. C., & Lee, S. J. (1997). Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences of U.S.A., 94, 12457-12461.
Mei, Q. B., Tao, J. Y., Gao, S. B., Xu, G. C., Chen, L. M., & Su, J. K. (1989). Antiarrhythmic effects of Cordyceps sinensis (Berk.) Sacc. China Journal of Chinese Materia Medica, 14(10), 616-618.
Mosler, S., Pankratz, C., Seyfried, A., Piechotta, M., & Diel, P. (2012). The anabolic steroid methandienone targets the hypothalamic-pituitarytesticular axis and myostatin signaling in a rat training model. Archives of Toxicology, 86, 109-119
Mouisel, E., Relizani, K., Mille-Hamard, L., Denis, R., Hourde, C., Agbulut, O., …Amthor, H. (2014). Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle. AJP Regulatory Integrative and Comparative Physiology, 307(4), R444-R454.
Moyer, A. L., & Wagner, K. R. (2015). Mammalian Mss51 is a skeletal muscle-specific gene modulating cellular metabolism. Journal of Neuromuscular Diseases, 2(4), 371-385.
Musaro, A., Giacinti, C., Borsellino Dobrowolny, G., Pelosi Cairns, L., Ottolenghi, S., Cassu, G., … & Rosenthal. N. (2004). Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proceedings of the National Academy of Sciences of the United States of America, 101, 1206-1210.
Nagata, A., Tajima, T., & Moriyasu, S. (2002). Effectiveness on ingestion with Cordyceps sinensis drinking during running exercise of humans. Journal of Exercise and Sports Physiology, 9, 85-92.
Nagata, A., Tajima, T., & Uchida, M. (2006). Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three step wise exercise in human. Japanese Journal of Physiology, Fitness, and Sports Medicine, 5, S145-S152.
Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E.,… & Evans, R.M. (2008). AMPK and PPARdelta agonists are exercise mimetics. Cell, 134, 405-415.
Norenberg, K. M., & Fitts, R. H. (2004). Contractile responses of the rat gastrocnemius and soleus muscles to isotonic resistance exercise. Journal of Applied Physiology, 97, 2322-2332.
Parcell, A. C., Smith, J. M., Schulthies, S. S., Myrer, J. W., & Fellingham, G. (2004). Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance. International Journal of Sport Nutrition and Exercise Metabolism, 14(2), 236-242.
Paterson, R.R.M. (2008). Cordyceps- a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry, 69, 1469-1495.
Peters, D., Barash, I. A., Burdi, M., Yuan, P. S., Mathew, L., Friden, J., & Lieber, R. L. (2003). Asynchronous functional, cellular and transcriptional changes after a bout of eccentric exercise in the rat. Journal of Physiology, 553, 947-957.
Pinheiro, J. C., & Bates, D. M. (2000). Mixed effects models in S and S-plus. New York, NY: Springer.
Raue, U., Slivka, D., Jemiolo, B., Hollon, C., & Trappe, S. W. (2006). Myogenic gene expression at rest and following a bout of resistance exercise in young (18–30 yr) and old (80–89 yr) women. Journal of Applied Physiology, 101, 53-59.
Rodman, L. E., Farnell, D. R., Coyne, J. M., Allan, P. W., Hill , D. L., Duncan, K. L. K., … Page, J. G. (1997). Toxicity of cordycepin in combination with the adenosine deaminase inhibitor 2'-Deoxycoformycin in Beagle Dogs. Toxicology & Applied Pharmacology, 147(1), 39-45.
Ronnestad, B. R., Egeland, W., Kvamme, N. H., Refsnes, P. E., Kadi, F., & Raastad, T. (2007). Dissimilar effects of one- and three-set strength training on strength and muscle mass gains in upper and lower body in untrained subjects. Journal of Strength & Conditioning Research, 21, 157-163.
Roth, S. M., Martel, G. F., Ferrell, R. E., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2003). Myostatin gene expression is reduced in humans with heavy-resistance strength training: A brief communication. Experimental Biology and Medicine, 228, 706-709.
Schuelke, M., Wagner, K. R., Stolz, L. E., Hubner, C., Riebel, T., Komen, W., … & Lee, S. J. (2004). Myostatin mutation associated with gross muscle hypertrophy in a child. New England Journal of Medicine, 350, 2682-2688.
Sculthorpe, N., Solomon, A. M., Sinanan, A. C., Bouloux, P. M., Grace, F., & Lewis, M. P. (2012). Androgens affect myogenesis in vitro and increase local IGF-1 expression. Medicine & Science in Sports & Exercise, 44(4), 610-615.
Singh, M. A., Ding, W., Manfredi, T. J., Solares, G. S., O'Neill, E. F., Clements, K. M., … Evans, W. J. (1999). Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. American Journal of Physiology, 277(1 Pt 1), E135-E143.
Singh, R., Negi, P.S., & Ahmed, J. (2009). Genetic variability assessment in medicinal caterpillar fungi Cordyceps spp. (Ascomycetes) in central Himalayas, India. International Journal of Medicinal Mushrooms, 11, 185-189.
Sprecher, D.L., Massien, C., Pearce, G., Billin, A.N., Perlstein, I., Willson, T.M., … & Johnson, T. G. (2007). Triglyceride: High-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 359-365.
Staron, R. S., Karapondo, D. L., Kraemer, W. J., Fry, A. C., Gordon, S. E., Falkel, J. E., … & Hikida, R. S. (1994). Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. Journal of Applied Physiology, 76(3), 1247-1255.
Suetta, C., Clemmensen, C., Andersen, J. L., Magnusson, S. P., Schjerling, P., & Kjaer, M. (2009). Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. Growth Hormone & IGF Research, 20(2), 134-140.
Tamaki, T., Uchiyama, S., & Nakano, S. (1992). A weightlifting exercise model for inducing hypertrophy in the hindlimb muscles of rats. Medicine & Science in Sports & Exercise, 24, 881-886.
Taylor, W. E., Bhasin, S., Artaza, J., Byhower, F., Azam, M., Willard, D. H. Jr., Kull, F. C. Jr., & Gonzalez-Cadavid, N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. American Journal of Physiology Endocrinology and Metabolism, 280, E221-E228.
Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., & Kambadur, R. (2000). Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. Journal of Biological Chemistry, 275, 40235-40243.
Thomas, B., & Walker, M. S. (2006). Does Cordyceps sinensis ingestion aid athletic performance? Strength and Conditioning Journal, 28(2), 21-23.
Timmons, J.A., Larsson, O., Jansson, E., Fischer, H., Gustafsson, T., Greenhaff, P.L., … & Sundburg,C, J. (2005). Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy. FASEB Journal, 19, 750-760.
Wang, Y.X., Zhang, C.L., Yu, R.T., Cho, H.K., Nelson, M.C., Bayuga-Ocampo, C.R., … & Evans, R.M. (2004). Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biology, 2(10), 1532-1539.
Widrick, J. J., & Fitts, R. H. (1988). Peak force and maximal shortening velocity of soleus fibers after non-weight-bearing and resistance exercise. Journal of Applied Physiology, 82, 189-195.
Wilborn, C. D., Taylor, L. W., Greenwood, M., Kreider, R. B., & Willoughby, D. S. (2009). Effects of different intensities of resistance exercise on regulators of myogenesis. Journal of Strength & Conditioning Research, 23(8), 2179-2187.
Willoughby, D. S. (2004). Effects of heavy resistance training on myostatin mRNA and protein expression. Medicine & Science in Sports & Exercise, 36, 574-582.
Wang, Y.X., Lee, C.H., Tiep, S., Yu, R.T., Ham, J., Kang, H., & Evans, R. M. (2003). Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell, 113, 159-170.
Wang, Y.X., Zhang, C.L., Yu, R.T., Cho, H.K., Nelson, M.C., Bayuga-Ocampo,C.R.,… & Evans, R. M. (2004). Regulation of muscle fiber type and running endurance by PPAR delta. PLoS Biology, 2, e294.
Wolfman, N. M., McPherron, A. C., Pappano, W. N., Davies, M. V., Song, K., Tomkinson, K. N., … & Lee, S. J. (2003). Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases. Proceedings of The National Academy of Sciences of USA, 100, 15842-15846.
Wong, T. S., & Booth, F. W.(1988). Skeletal muscle enlargement with weightlifting exercise by rats. Journal of Applied Physiology, 65, 950-954.
Xiao, Y., Huang, X., & Chen, Z.G., (1999). Increased aerobic capacity in healthy elderly humans given a fermentation product of cordyceps Cs-4. Medicine & Science in Sports & Exercise, 31(5), S174.
Yamaguchi, A., Fujikawa, T., Shimada, S., Kanbayashi, I., Tateoka, M., Soya, H., … & Hirai, T. (2006). Muscle IGF-I Ea, MGF, and myostatin mRNA expressions after compensatory overload in hypophysectomized rats. Pflügers Archiv European Journal of Physiology, 453, 203-210.
Yang, S. Y., & Goldspink, G. (2002). Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Letters, 522 (1-3), 156-160.
Yi, X., Xi-zhen, H., & Jia-shi, Z. (2004). Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs- 4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Chinese Journal of Integrative Medicine, 10, 187-192.
Zhao, C. S., Yin, W. T., Wang, J. Y., Zhang, Y., Yu, H., Cooper, R., … & Zhu, J. S. (2002). CordyMax™ Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats. Journal of Alternative and Complementary Medicine, 8(3), 309-314.
Zhu, J. S., Halpern, G. M., & Jones, K. (1998a). The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis Part I. Journal of Alternative and Complementary Medicine, 4(3), 289-303.
Zhu, J. S., Halpern, G. M., & Jones, K. (1998b). The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis Part II. Journal of Alternative and Complementary Medicine, 4 (4), 429-457.
Zhu, J. S., & Rippe, J. M. (2004). CordyMax enhances aerobic exercise capacity and metabolism, and endurance performance in healthy, mid-age to elderly, sedentary humans. FASEB Journal, 18(5), A931.