本研究使用了一種快速的方式結合電噴灑質譜法(ESI-MS)的檢測技術，利用毛筆當作採樣的工具，沾取甲醇後輕刷採樣放置於質譜入口和電噴灑的針尖。由於甲醇溶劑易揮發的特性，因此分析物會隨著溶劑從毛筆表面上逸出。當分析物與電噴灑輔助溶劑的帶電粒子接觸會使分析物被離子化，而分析物將被一起游離透過質譜儀進行檢測。本實驗透過此技術應用於農藥殘留的檢驗，以沾甲醇的毛筆在橘子表面塗抹，收集殘留於橘子表面的腐絕農藥，並且根據橘子表面上殘留的腐絕做了放置不同時間下以及用不同方式清洗橘子表面後的農藥殘留。以證明此方法用於農藥殘留檢驗的可行性，以及相較傳統不須經過前處理準備的方便和快速性。

A rapid approach that combines the detection technique of electrospray ionization mass spectrometry (ESI-MS) with the use of a brush as a sampling tool. The brush was dipped in methanol and lightly brushed on the sample surface, specifically at the mass spectrometer inlet and the tip of the electrospray needle. Due to the volatile nature of the methanol solvent, the analytic would evaporate from the brush surface along with the solvent. When the analytic came into contact with the charged particles of the electrospray-assisting solvent, they were ionized, and the ionized analyses were subsequently detected by the mass spectrometer. This technique was applied in this experiment for the analysis of pesticide residues. A methanol-dipped brush was used to swipe across the surface of oranges to collect the pesticide residues present. Different durations of brush contact and various surface cleaning methods were tested to investigate the pesticide residue levels remaining on the orange surface. This was done to demonstrate the feasibility of this method for pesticide residue analysis and its convenience and rapidity compared to traditional preparation methods that do not require prior treatment.

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