目的：利用月經週期溫度的變化，找出女性在不同運動強度下，哪一月經週期能消耗最多能量。方法：選取12名規律月經週期的女性 (年齡：22.2 ± 1.5 yrs；身高：162.3 ± 2.8 cm；體重：55.3 ± 3.5 kg)，自我測量基礎體溫一個月後，依平衡次序方式分別在不同週期 (濾泡期、黃體期與行經期) 進行間斷遞增強度的跑步機運動，強度分為35%、55%及75%HRR三種，各運動10分鐘，運動期間全程配戴Polar錶及攝氧量分析儀，用以觀察心率、 攝氧量 (VO2) 、呼吸交換率（RER）、能量消耗及能量消耗來源等變項。結果：1.運動中的能量代謝：月經週期對運動中的受質代謝(醣類/脂肪)皆無顯著差異，但能量消耗在35%HRR運動強度下，行經期會顯著高於濾泡期； 在55%HRR運動強度時，黃體期與行經期皆會顯著高於濾泡期; 在75%HRR運動強度時，不同月經週期間皆無顯著差異。2.恢復期的能量代謝：月經週期在三種不同運動強度的恢復期皆無顯著差異，醣類/脂肪動用的比例也無顯著差異。3.總流程(運動+恢復)的能量代謝：黃體期 (250.8±17.7 Kcal) 及行經期 (260.7±24.7 Kcal) 的能量消耗顯著高於濾泡期(239.4±18.0 Kcal) ；在受質代謝的部分則可觀察到黃體期動用到醣類的部分會比濾泡期來的高。4.心率變化：黃體期在三種運動強度下的心跳率皆會顯著大於濾泡期。結論：1.黃體期及行經期可消耗較多的能量，其中又以中強度運動最為明顯，建議想利用月經週期變化來減重者，可多利用黃體期與行經期執行運動計畫。2.月經週期對受質代謝並無顯著差異可能與運動強度及時間有關，建議未來若想觀察到受質代謝上的差異，可增加強度及時間來做比較。3.由於黃體期的心率較高，如果執行運動訓練時是以心率來監控強度，須考慮週期性的變化來調整強度心跳率

Purpose: To study the effects of different menstrual phases with different exercise intensities on energy metabolism. Methods: Twelve healthy females (age: 22.2±1.5 yrs；height：162.3±2.8 cm；weight：55.3±3.5 kg) with normal menstrual cycles were recruited. All subjects monitored basal body temperature for a mouth, then performed an intermittent incremental exercises on treadmill in three different menstrual phases ( luteal phase, LP；follicular phase, FP; and menstruation, MP ) in a counter-balanced order. The three exercise intensities were 35%, 55% and 75% heart rate reserve (HRR), each exercises levels were 10 minutes in duration. The heart rate, energy expenditure and substrate metabolism were measured by Polar S725x and Vmax 29 . Results: 1. Energy metabolism during exercise : There is no different on substrate metabolism in different menstrual phases, but the energy expenditure during MP was significantly higher than FP at 35% HRR exercise. At 55%HRR, the energy expenditure during LP and MP were significantly higher than FP. Energy expenditure at different menstrual phases were not significantly different at 75%HRR. 2. Energy metabolism during recovery stage: Energy expenditure and substrate metabolism at different menstrual phases and intensities were not significantly different. 3. Energy metabolism for the whole exercise test (exercise + recovery): Energy expenditure during LP (250.8±17.7 Kcal) and MP (260.7±24.7 Kcal) were significantly higher than FP (239.4±18.0 Kcal). The carbohydrate metabolism during LP was significantly higher than FP. 4. Heart rate variation: Heart rate during LP is significantly higher than FP at all exercise intensities. Conclusions: 1. Druing LP and MP will expend more calorie during exercise, and it was more pronounce at moderate intensity exercise. If women want to use menstrual cycle change to lose weight, this study recommend to do exercise during LP and MP. 2. No differences on substrate metabolism in different menstrual phases may relate to exercise intensity and duration. Metabolic studies should use higher intensity and duration in the future. 3. Exercise heart rate should be monitored because of higher heart rate during LP.

王鶴森 (2001)。月經週期對換氣閾值及運動時生理反應的影響。體育學報，31，229-238。

王鶴森 (2006)。濾泡與黃體期間從事中等強度運動對血漿飢餓素及瘦體素濃度的影響。未出版博士論文，國立臺灣師範大學，台北市。

吳燕珊 (2003)。月經週期與月經症候群對大專排球選手運動表現之影響。未出版碩士論文，國立臺灣師範大學，台北市。

鄒瑜 (2006)。少年女子武術運動員月經週期中的訓練安排。萍鄉高等專科學校學報，5，67-68。

鄒孟婷 (2006)。臺灣成年女性肥胖、自覺肥胖和健康知識與教育程度之關係。臺灣家庭醫學雜誌，16(4)，237-250。

趙文燕、董耀、仇樹林 (2005)。脂肪細胞雌激素受體的表達及其與人體脂肪分佈的相關性。中國美容醫學， 5， 534-536。

賴韻如、洪孜幸、黃國晉 (2008)。 “促進台灣國民營養飲食與健康生活形態：回顧與展望”專刊系列報導－臺灣人體位現況及相關健康促進策略。臺灣營養學會雜誌，33(4)，116-123。

鐘瑩瑩、陳仁佑、張育驍、林錦龍、黃麗卿 (2005)。台北市國宅居民運動習慣及相關因素之探討。中華職業醫學雜誌,，12(2)，99-106。

Aoyagi, Y., McLellan, T. M., & Shephard, R. J. (1997). Interactions of physical training and heat acclimation. The thermophysiology of exercising in a hot climate. Sports Medicine , 23(3), 173-210.

Auwerx, J., & Staels, B. (1998). Leptin. Lancet, 351, 737-742.

Bahr, R., Hansson, R., & Sejersted, O. M. (1990). Triglyceride/fatty acid cycling is increased after exercise. Metabolism: Clinical and Experimental, 39(9), 993-999.

Beidleman, B. A., Rock, P. B., Muza, S. R., Fulco, C. S., Forte, V. A. J., & Cymerman, A. (1999). Exercise VE and physical performance at altitude are not affected by menstrual cycle phase. Journal of Applied Physiology, 86(5), 1519-1526.
Bemben, D. A., Salm, P. C., & Salm, A. J. (1995). Ventilatory and blood lactate responses to maximal treadmill exercise during the menstrual cycle. Journal of Sports Medicine and Physical Fitness, 35(4), 257-262.

Birch, K. M., & Reilly, T. (1997). The effect of eumenorrheic menstrual cycle phase on physiological responses to a repeated lifting task. Canadian Journal of Applied Physiology 22(2), 148-160.

Bisdee, J. T., James, W. P., & Shaw, M. A. (1989). Changes in energy expenditure during the menstrual cycle. British Journal of Nutrition, 61(2), 187-199.

Blunt, K., & Dye, M. (1921). Basal metabolism of normal women. Journal of Biological Chemistry, 67, 69-87.

Bonen, A., Haynes, F., Watson-Wright, W., Sopper, M., Pierce, G., Low, M., et al. (1983). Effects of menstrual cycle on metabolic responses to exercise. Journal of Applied Physiology, 55(5), 1506-1513.

Campbell, S. E., Angus, D. J., & Febbraio, M. A. (2001). Glucose kinetics and exercise performance during phases of the menstrual cycle: Effect of glucose ingestion American Journal of Physiology. Endocrinology and Mmetabolism, 281(4), E817-825.

Campbell, S. E., & Febbraio, M. A. (2002). Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake. American Journal of Physiology. Endocrinology and Metabolism, 282(5), E1139-1146.

Cella, F., Giordano, G., & Cordera, R. (2000). Serum leptin concentrations during the menstrual cycle in normal-weight women: Effects of an oral triphasic estrogen-progestin medication. European Journal of Endocrinology, 142, 174-178.

Chapman, J. F., McIntyre, M. H., Lipson, S. F., & Ellison, P. T. (2009). Weight change and ovarian steroid profiles in young women. Fertility and Sterility, 91(3), 858-861.

De Crée, C. (1998). Sex steroid metabolism and menstrual irregularities in the exercising female. A review. Sports Medicine, 25(6), 369-406.

De Souza, M. J., Maresh, C. M., Maguire, M. S., Kraemer, W. J., Flora-Ginter, G., & Goetz, K. L. (1989). Menstrual status and plasma vasopressin, renin activity, and aldosterone exercise responses. Journal of Applied Physiology, 67(2), 736-743.

De Souza, M. J., Maguire, M. S., Rubin, K. R., & Maresh, C. M. (1990). Effects of menstrual phase and amenorrhea on exercise performance in runners. Medicine and Science in Sports and Exercise, 22(5), 575-580.

Devries, M. C., Hamadeh, M. J., Graham, T. E., & Tarnopolsky, M. A. (2005). 17beta-estradiol supplementation decreases glucose rate of appearance and disappearance with no effect on glycogen utilization during moderate intensity exercise in men. Journal of Clinical Endocrinology and Metabolism, 90(11), 6218-6225.

Devries, M. C., Hamadeh, M. J., Phillips, S. M., & Tarnopolsky, M. A. (2006). Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 291(4), 1120-1128.

Donnelly, J. E., Blair, S. N., Jakicic, J. M., Manore, M. M., Rankin, J. W., Smith, B. K., et al. (2009). American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Medicine and Science in Sports and Exercise, 41(2), 459-471.

Ellis, G. S., Lanza-Jacoby, S., Gow, A., & Kendrick, Z. V. (1994). Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats. Journal of Applied Physiology, 77(1), 209-215.

Galliven, E. A., Singh, A., Michelson, D., Bina, S., Gold, P. W., & Deuster, P. A. (1997). Hormonal and metabolic responses to exercise across time of day and menstrual cycle phase. Journal of Applied Physiology, 83(6), 1822-1831.

Garcia-Mayor, R. V., Andrade, M. A., Rios, M., Lage, M., Dieguez, C., & Casanueva, F. F. (1997). Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. Journal of Clinical Endocrinology and Metabolism, 82(9), 2849-2855.

Geisthövel, F., Jochmann, N., Widjaja, A., Horn, R., & Brabant, G. (2004). Serum pattern of circulating free leptin, bound leptin, and soluble leptin receptor in the physiological menstrual cycle Fertility and Sterility 81(2), 398-402.

Hackney, A. C., Curley, C. S., & Nicklas, B. J. (1991). Physiological responses to submaximal exercise at the mid-follicular, ovulatory and mid-luteal phases of the menstrual cycle. Scandinavian Journal of Medicine & Science in Sports, 1(2), 94-98.

Hackney, A. C., McCracken-Compton, M. A., & Ainsworth, B. (1994). Substrate responses to submaximal exercise in the midfollicular and midluteal phases of the menstrual cycle. International Journal of Sport Nutrition, 4(3), 299-308.

Hardie, L., Trayhurn, P., Abramovich, D., & Fowler, P. (1997). Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clinical Endocrinology, 47(1), 101-106.

Horton, T. J., Miller, E. K., & Bourret, K. (2006). No effect of menstrual cycle phase on glycerol or palmitate kinetics during 90 min of moderate exercise. Journal of Applied Physiology, 100(3), 917-925.

Horton, T. J., Miller, E. K., Glueck, D., & Tench, K. (2002). No effect of menstrual cycle phase on glucose kinetics and fuel oxidation during moderate-intensity exercise. American Journal of Physiology. Endocrinology and Metabolism, 282(4), E752-762.

Jurkowski, J., Jones, N., Walker, W., Younglai, E., & Sutton, J. (1978). Ovarian hormonal responses to exercise. Journal of Applied Physiology,44, 109–114.

Keizer, H. A., Poortman, J., & Bunnik, G. (1980). Influence of physical exercise on sex-hormone metabolism. Journal of Applied Physiology, 48, 765–769.

Keizer, H. A., & Rogol, A. D. (1990). Physical exercise and menstrual cycle alterations. What are the mechanisms. Sports Medicine, 10(4), 218-235.

Kishali, N. F., Imamoglu, O., Katkat, D., Atan, T., & Akyol, P. (2006). Effects of menstrual cycle on sports performance. The International Journal of Neuroscience, 116(12), 1549-1563.

Larson, D. E., Ferraro, R. T., Robertson, D. S., & Ravussin, E. (1995). Energy metabolism in weight-stable postobese individuals. American Journal of Clinical Nutrition, 62(4), 735-739.
Lebrun, C. M. (1993). Effect of the different phases of the menstrual cycle and oral contraceptives on athletic performance. Sports Medicine, 16(6), 400-430.

Ley, C. J., Lees, B., & Stevenson, J. C. (1992). Sex- and menopause-associated changes in body-fat distribution. American Journal of Clinical Nutrition, 55(5), 950-954.

Loucks, A. B. (1990). Effects of exercise training on the menstrual cycle: existence and mechanisms. Medicine and Science in Sports and Exercise, 22(3), 275-280.

Ludwig, M., Klein, H. H., Diedrich, K., & Ortmann, O. (2000). Serum leptin concentrations throughout the menstrual cycle. Archives of Gynecology and Obstetrics, 263, 99-101.

Matsuo, T., Saitoh, S., & Suzuki, M. (1999). Effects of the menstrual cycle on excess postexercise oxygen consumption in healthy young women. Metabolism: Clinical and Experimental, 48(3), 275-277.

McLaren, L. (2007). Socioeconomic status and obesity. Epidemiologic Reviews, 29, 29-48.

Meijer, G. A., Westerterp, K. R., Saris, W. H., & ten Hoor, F. (1992). Sleeping metabolic rate in relation to body composition and the menstrual cycle. American Journal of Clinical Nutrition, 55(3), 637-640.

Middleton, L. E., & Wenger, H. A. (2006). Effects of menstrual phase on performance and recovery in intense intermittent activity. European Journal of Applied Physiology, 96(1), 53-58.

Nicklas, B. J., Hackney, A. C., & Sharp, R. L. (1989). The menstrual cycle and exercise: performance, muscle glycogen, and substrate responses. International Journal of Sports Medicine, 10(4), 264-269.

Pasquier, Y. N., Pecquery, R., & Giudicelli, Y. (1988). Increased adenylate cyclase catalytic activity explains how estrogens "in vivo" promote lipolytic activity in rat white fat cells. Biochemical and Biophysical Research Communications, 154(3), 1151-1159.

Pate, R. R., Pratt, M., Blair, S., Haskell, W. L., Macera, C. A., Bouchard, C., et al. (1995). Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. Journal of The American Medical Association, 273(5).

Piers, L. S., Diggavi, S. N., Rijskamp, J., van Raaij, J. M., Shetty, P. S., & Hautvast, J. G. (1995). Resting metabolic rate and thermic effect of a meal in the follicular and luteal phases of the menstrual cycle in well-nourished Indian women. American Journal of Clinical Nutrition, 61(2), 296-302.

Pivarnik, J. M., Marichal, C. J., Spillman, T., & Morrow, J. R. J. (1992). Menstrual cycle phase affects temperature regulation during endurance exercise. Journal of Applied Physiology, 72(2), 543-548.

Position stand of the American College of Sports Medicine. (1993). The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness in healthy adults. Schweizerische Zeitschrift für Sportmedizin, 41(3), 127-137.

Powers, S. K., Beadle, R. E., Lawler, J., & Thompson, D. (1987). Oxygen deficit-oxygen debt relationships in ponies during submaximal treadmill exercise. Respiration Physiology, 70(2), 251-263.

Redman, L. M., Scroop, G. C., & J., N. R. (2003). Impact of menstrual cycle phase on the exercise status of young, sedentary women. European Journal of Applied Physiology, 90(5-6), 505-513.

Redman, L. M., Scroop, G. C., Westlander, G., & Norman, R. J. (2005). Effect of a synthetic progestin on the exercise status of sedentary young women. Journal of Clinical Endocrinology and Metabolism, 90(7), 3830-3837.

Sahu, A. (2003). Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Frontiers in Neuroendocrinology, 24(4), 225-253.

Schoene, R. B., Robertson, H. T., Pierson, D. J., & Peterson, A. P. (1981). Respiratory drives and exercise in menstrual cycles of athletic and nonathletic women. Journal of Applied Physiology, 50, 1300-1305.

Slauterbeck, J. R., Fuzie, S. F., Smith, M. P., Clark, R. J., Xu, K., Starch, D. W., et al. (2002). The menstrual cycle, sex hormones, and anterior cruciate ligament injury. Journal of Athletic Training, 37(3), 275-278.

Solomon, S. J., Kurzer, M. S., & Calloway, D. H. (1982). Menstrual cycle and basal metabolic rate in women. American Journal of Clinical Nutrition, 36, 611-616.

Suh, S. H., Casazza, G. A., Horning, M. A., Miller, B. F., & Brooks, G. A. (2003). Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise. Journal of Applied Physiology, 94(1), 285-294.

Sunderland, C., & Nevill, M. (2003). Effect of the menstrual cycle on performance of intermittent, high-intensity shuttle running in a hot environment. European Journal of Applied Physiology, 88(4-5), 345-352.

Tai, M. M., Castillo, T. P., & Pi-Sunyer, F. X. (1997). Thermic effect of food during each phase of the menstrual cycle. American Journal of Clinical Nutrition, 66(5), 1110-1115.

Tsai, W. L., Yang, C. Y., Lin, S. F., & Fang, F. M. (2004). Impact of obesity on medical problems and quality of life in Taiwan. American Journal of Epidemiology, 160(6), 557-565.

Webb, P. (1986). 24-hour energy expenditure and the menstrual cycle. American Journal of Clinical Nutrition, 44(5), 614-619.

Wing, R. R., & Phelan, S. (2005). Long-term weight loss maintenance. American Journal of Clinical Nutrition, 82(1 Suppl), 222S-225S.

Wiltshire, M. (1921). Some observations on basal metabolism in menstruation. Lancet, 2, 338-889.

Zderic, T. W., Coggan, A. R., & Ruby, B. C. (2001). Glucose kinetics and substrate oxidation during exercise in the follicular and luteal phases. Journal of Applied Physiology, 90(2), 447-453.