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Author: 詹紫涵
Chan, Tzu-Han
Thesis Title: 支鏈胺基酸增補對下坡跑後肌肉生長抑制激素-myostatin及肌肉損傷與發炎指標之影響
Effects of Supplementation of Branched Chain Amino Acids on Myostatin and Muscle Injury and Inflammation Biomarkers following Downhill Running
Advisor: 王鶴森
Wang, Ho-Seng
陳勇志
Chen, Yung-Chih
Committee: 王鶴森
Wang, Ho-Seng
陳勇志
Chen, Yung-Chih
陳厚諭
Chen, Hou-Yu
Approval Date: 2021/10/29
Degree: 碩士
Master
Department: 體育與運動科學系
Department of Physical Education and Sport Sciences
Thesis Publication Year: 2024
Academic Year: 112
Language: 中文
Number of pages: 54
Keywords (in Chinese): GDF-8增補劑肌少症肌肥大
Keywords (in English): GDF-8, energetic aid, sarcopenia, muscle hypertrophy
Research Methods: 實驗設計法
DOI URL: http://doi.org/10.6345/NTNU202401519
Thesis Type: Academic thesis/ dissertation
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  • 研究背景:肌肉生長抑制激素 (myostatin, MSTN) 是肌肉生長的負調控因子,而運動誘發肌肉損傷 (exercise-induced muscle damage, EIMD),會引起 MSTN 濃度的改變。過去研究指出增補支鏈胺基酸 (branched-chain amino acids, BCAA) 似乎能夠減緩EIMD,但對於 MSTN 的影響仍不清楚。本研究目的為探討增補 BCAA 在單次激烈運動過後對 MSTN 及肌肉損傷及發炎指標之影響。方法:13位健康男性 (23.6 ± 4.8歲) 依照平衡次序法接受 BCAA + 下坡跑 (BCAA) 或安慰劑 + 下坡跑 (PLA) 處理。增補時間點共三次,分別為運動前15分鐘、運動後立即與運動後3小時,受試者每次增補劑量為100 mg/kg。於增補前 (pre)、運動後立即 (0 h)、運動後3小時 (3 h)、運動後24小時 (24 h)、運動後48小時 (48 h) 五個時間點,測量血漿 MSTN、血清介白素6 (interleukin 6, IL-6)、血清肌酸激酶 (creatine kinase, CK)、延遲性肌肉痠痛 (delayed-onset muscle soreness, DOMS) ,及最大等長肌力 (maximum voluntary isometric contraction, MVIC) 五個指標。所得數據以重複量數二因子變異數分析進行統計處理以及皮爾森積差相關進行分析。結果:MSTN變化率有交互作用 (p=.046),BCAA以及PLA處理在0 h與3 h顯著高於pre,BCAA 處理 48 h 顯著高於 24 h;PLA 處理 48 h 顯著低於 0 h、3 h。IL-6無交互作用,0 h 顯著高於 pre,3 h 顯著高於其餘四時間點。DOMS 有交互作用 (p=.012),在 3 h 及 24h,BCAA 顯著低於 PLA 處理。CK 以及 MVIC 無交互作用,後測四個時間點與 pre 達顯著。MSTN 與 CK、IL-6 在 0 h 與 3 h 分別呈現中度正相關。結論:本研究發現 MSTN 會在單次激烈運動後立即上升,並且與 IL-6、CK 等指標呈現正相關,推測 EIMD 會短暫造成 MSTN 上升,且增補 BCAA 並不會抑制此現象,但會暫時減緩 DOMS 的發生。

    Background: Myostatin (MSTN) is the negative signalling factor for muscle growth. Exercise-induced muscle damage (EIMD) would alter MSTN levels. Previous studies had indicated branched-chain amino acids (BCAA) supplementation might alleviate EIMD, but the effect on MSTN remains unclear. This study aims to investigate the effects of BCAA supplementation on MSTN and muscle damage indicators following a single bout of intense exercise. Methods: Thirteen healthy males (aged 23.6 ± 4.8 years) receiving either BCAA with downhill running (BCAA) or placebo with downhill running (PLA) with a randomized, counterbalanced design. Participants were all supplemented with 100 mg/kg of BCAA/PLA at 15 min before exercise, immediately after exercise and 3 h after exercise. Plasma MSTN, serum interleukin 6 (IL-6), serum creatine kinase (CK), delayed-onset muscle soreness (DOMS), and maximum voluntary isometric contraction (MVIC) were measured at five time points: pre-supplementation (pre), immediately after exercise (0 h), 3 hours post-exercise (3 h), 24 hours post-exercise (24 h), and 48 hours post-exercise (48 h). Data were analysed using two-way ANOVA repeated measure and Pearson correlation of statistical analysis. Results: There was a significant interaction effect on MSTN levels (p=.046). In the BCAA treatment, MSTN levels were significantly higher at 0 h and 3 h compared to pre-exercise, and at 48 h compared to 24 h. In the PLA treatment, MSTN levels were significantly higher at 0 h and 3 h compared to pre-exercise, and significantly lower at 48 h compared to 0 h and 3 h. IL-6 showed no interaction effect but was significantly higher at 0 h compared to pre-exercise, and at 3 h compared to the other time points. CK showed no interaction effect but was significantly higher at 0 h, 3 h, 24 h, and 48 h compared to pre-exercise, with 3 h and 24 h significantly higher than 0 h, and 24 h significantly higher than 3 h and 48 h. DOMS showed a significant interaction effect (p=.012), with BCAA significantly lower than PLA at 3 h and 24 h. MSTN was positively correlated with CK and IL-6 at 0 h and 3 h. Conclusion: This study found MSTN levels increased after a single bout of intense exercise and positively correlated with IL-6 and CK. It is suggested that EIMD temporarily increased MSTN levels, and BCAA supplementation did not inhibit this increase but temporarily alleviated DOMS.

    第壹章 緒論 1 第一節 前言 1 第二節 研究目的 3 第三節 研究假設 3 第四節 名詞操作型定義 3 第五節 研究範圍及限制 4 第六節 研究重要性 4 第貳章 文獻探討 5 第一節 myostatin的發現與功能 5 第二節 運動對myostatin之影響 7 第三節 運動誘發之肌肉損傷對myostatin之影響 11 第四節 增補BCAA於耐力運動中的應用 14 第五節 增補BCAA對myostatin之影響 16 第六節 文獻總結 18 第參章 研究方法 19 第一節 實驗參與者 19 第二節 實驗時間與地點 19 第三節 實驗流程 19 第四節 實驗方法與步驟 21 第五節 資料處理與統計分析 26 第肆章 研究結果 27 第一節 受試者基本資料 27 第二節 肌肉激素、肌肉損傷及發炎指標結果 28 第三節 myostatin與IL-6、CK變化率之相關分析 32 第伍章 討論 33 第一節 增補BCAA對單次下坡跑後肌肉激素分泌之影響 33 第二節 增補BCAA對單次下坡跑後EIMD之影響 35 第三節 myostatin與IL-6及CK之關聯 38 第陸章 結論 38 參考文獻 39 附錄一 49 附錄二 54

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