Author: |
陳錡翰 chi-han, Chen |
---|---|
Thesis Title: |
利用有機不對稱催化建構具有多取代的環己酮衍生物 Enantioselective synthesis of multi-substituted cyclohexanone derivatives via organocatalytic asymmetric double michael addition |
Advisor: |
林文偉
Lin, Wen-Wei |
Degree: |
碩士 Master |
Department: |
化學系 Department of Chemistry |
Thesis Publication Year: | 2014 |
Academic Year: | 102 |
Language: | 中文 |
Number of pages: | 23 |
Keywords (in Chinese): | 連續性反應 、環己酮 、鏡像選擇性 |
Keywords (in English): | Domino reaction, Enantioselectivity |
Thesis Type: | Academic thesis/ dissertation |
Reference times: | Clicks: 275 Downloads: 0 |
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a,b-不飽和-1,3-雙酮和亞烷基丙二腈為起始物透過奎寧進行連續性的二次 Michael 加成反應,得到具有兩個立體中心的多取代環己酮衍生物,產率為 59-94%、單一非鏡像異構物和高達 92% 的鏡像超越值。
organocatalytic asymmetric double Michael addition reaction of a,b-unsaturated-1,3-diketones to 2-alkylidene malononitriles 80 has been investigated with quinine as the catalyst to afford a range of multi-substituted cyclohexanones bearing two sterecenters in good results (58-94% yield, >99:1 de, and up to 92% ee).
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