Author: |
李宜諺 Li, Yi-Yan |
---|---|
Thesis Title: |
光與磁造影之超導生醫磁導儀應用於探討肝腫瘤的標靶造影 Scanning SQUID Biosusceptometery Applied to Exploring of Hepatocellular Carcinoma Targeted by Optics and Magnetic Dual-Mode Imaging. |
Advisor: |
謝振傑
Chieh, Jen-Jie |
Degree: |
碩士 Master |
Department: |
光電工程研究所 Graduate Institute of Electro-Optical Engineering |
Thesis Publication Year: | 2015 |
Academic Year: | 103 |
Language: | 中文 |
Number of pages: | 29 |
Keywords (in Chinese): | 磁性奈米粒子 、超導磁導儀 、批覆生物探針 、交流磁化率 |
Thesis Type: | Academic thesis/ dissertation |
Reference times: | Clicks: 136 Downloads: 4 |
Share: |
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現今醫學影像方面如斷層掃描、核磁共振造影、X-Ray,都具有高解析度的斷層影像,但因為維護價格高與屏蔽系統需要夠良好,所以,往往只有大型醫療機構擁有。為了增加靈敏度與專一性,批覆生物探針的奈米粒子已成為主流,利用批覆胎兒蛋白(Alpha-fetoprotein,AFP)抗體、批覆去羧機凝血脢原(Des gamma carboxy prothrombin,DCP)、批覆酯肌醇蛋白聚醣3(Glypican-3,GPC3 )抗體的磁性奈米流體,注射於癌鼠做標靶實驗,並開發出光學與磁學雙模式的超導磁導儀檢測磁性奈米粒子的交流磁化率。本實驗除了用磁導儀對注射磁流體試劑的癌鼠進行檢測,利用核磁共振造影與肝臟五葉個別量測的一致性證實了磁導儀可行性。因此,未來病患可注射批覆抗體的磁性奈米粒子試劑後進行活體篩檢,如果有腫瘤症狀,需要進一步確認再進行高額的其他檢查,減少民眾負擔。
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