在本研究在屏蔽屋內架設一套使用高溫超導量子干涉元件(High Temperature Superconducting Quantum Interference Devices, High-Tc SQUID)的磁粒子造影系統(Magnetic Particle Imaging, MPI)。因為High-Tc SQUID是一種靈敏度極高的磁力計，所以適合應用於微小磁性感測，量測在未來可被作為標靶顯影劑且生物相容性極高的奈米磁粒子。
本系統具有極低之背景雜訊，在1 Hz與100 Hz時的系統雜訊頻譜分別為43.390 pT/Hz1/2與1.462 pT/√Hz1/2，並使用交流模式掃描樣品，最大掃描範圍為12 cm × 12 cm。系統最小樣品量測為0.031 M，100 µL。同時配合步進馬達來移動樣品來提升空間解析度，最後透過小範數估計法(Minimum-Norm Estimation, MNE)來重建樣品在空間中的分布，進一步再利用侷限座標法得到更貼近樣品形貌的重建影像。本研究並將磁粒子造影系統所量測到的功能性影像與磁振造影的結構性影像整合，驗證於磁性生醫影像應用的可行性。

In this study, a magnetic particle imaging system (MPI) using High Temperature Superconducting Quantum Interference Devices (High-Tc SQUID) was installed in the shielded house. Because High-Tc SQUID is a highly sensitive magnetometer, it is suitable for small magnetic sensing, measuring nano magnetic particles that can be used as target developers in the future and have high biocompatibility.
The system has extremely low background noise. The system noise spectrum at 1 Hz and 100 Hz is 43.390 pT /Hz1/2 and 1.462 pT /Hz1/2, respectively, and the sample is scanned using the AC measurement mode. At present, the limit of the system can detect sample concentration is 0.031 M, 100 μL .The maximum scan area is 12 cm × 12 cm, with a stepping motor to move the sample to improve the spatial resolution, and finally through the Mini-Norm Estimation (MNE) to reconstruct the distribution of the sample in space, and further use the constraint coordinate method calculate reconstructed image that is closer to the topography of the sample.
In this study, the functional image measured by the magnetic particle imaging system was integrated with the structural image of the magnetic resonance imaging to verify the feasibility of the magnetic biomedical imaging application.

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